Immunotherapeutic approaches for fungal infections

Williams, Thomas J; Harvey, Sunshine; Armstrong‐James, Darius

doi:10.1016/j.mib.2020.09.007

Cited by 20 publications

(12 citation statements)

References 59 publications

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“…Although not discussed in this review, there is evidence that fungal cells themselves undergo programmed cell death [96,97]. Once the interactions between the host and fungi in regard to cell death are further understood, the benefits of therapeutic approaches targeting these pathways could be assessed, as many other therapies manipulating the immune system are already being employed for fungal infections including monoclonal antibodies, cytokine therapies, and adoptive cell transfers [98,99]. Fully understanding the complex-death interaction between the host cell and fungi may open up a whole range of novel therapeutics to combat disease.…”

Section: Discussionmentioning

confidence: 99%

Fungal-Induced Programmed Cell Death

Williams¹,

Gonzales-Huerta²,

Armstrong‐James³

2021

JoF

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Fungal infections are a cause of morbidity in humans, and despite the availability of a range of antifungal treatments, the mortality rate remains unacceptably high. Although our knowledge of the interactions between pathogenic fungi and the host continues to grow, further research is still required to fully understand the mechanism underpinning fungal pathogenicity, which may provide new insights for the treatment of fungal disease. There is great interest regarding how microbes induce programmed cell death and what this means in terms of the immune response and resolution of infection as well as microbe-specific mechanisms that influence cell death pathways to aid in their survival and continued infection. Here, we discuss how programmed cell death is induced by fungi that commonly cause opportunistic infections, including Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, the role of programmed cell death in fungal immunity, and how fungi manipulate these pathways.

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Section: Discussionmentioning

confidence: 99%

Fungal-Induced Programmed Cell Death

Williams¹,

Gonzales-Huerta²,

Armstrong‐James³

2021

JoF

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“…Integration of innate immune recognition and adaptive immunity is critical for the control of invasive mycoses. The relevance of the basic knowledge in the immunopathogenesis of mycoses can be observed by the growth in clinical immunomodulation studies (Williams et al, 2020). Thus, comprehension of the immunity to fungal pathogens offers new possibilities for the treatment of invasive mycoses.…”

Section: Immunity To Fungal Infections: Insights From the Innate Immune Recognition And Antifungal Effector Mechanismsmentioning

confidence: 99%

Editorial: Immunity to Fungal Infections: Insights From the Innate Immune Recognition and Antifungal Effector Mechanisms

2021

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“…Fungal infections affect 1/4 of the world's population and about 1.5 million people were killed each year, even surpassing the populations killed by either malaria, breast cancer, lung cancer or prostate cancer. [1] Candida albicans (C. albicans) infection is the most prevalent fungal pathogen of humans. An unusually broad range of human infections are related to this, such as the microbial keratitis (MK), colpomycosis, pneumonia, gastroenteritis, endocarditis, meningitis, encephalitis and many other inflammations.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

et al. 2021

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Here, we have strategically prepared a biodegradable ionic covalent organic porous polymers (ICOP) with dynamic double selenium bond (SeÀ Se) which was further used as carriers for the antifungal drug-natamycin (NAT). ICOP presents a high drug-loading capability (DL) of 79.33 � 0.12 %, as well as high encapsulation efficiency (EE) of 76.75 � 0.58 % to NAT. Meanwhile, owning to the simultaneous introduction of À SeÀ SeÀ bond and imine linkage, the composite drug delivery system are responsive to pH, with selective and sustained release in acidic media (pH = 5.5), almost 1.34 fold as much as that in neutral conditions (pH = 7.4). This special drug release behavior is consisted well with the optimum growing environment of candida albicans (pH = 5.5), in which, more drugs could be released continuously, enhancing the duration of drug interactions with fungi and inhibiting the growth of fungus effectively. This novel dosing strategy is promising for the development of intelligent drug delivery system which could avoid the overdoses of drugs, and reduce the emergence of resistant strains.

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Immunotherapeutic approaches for fungal infections

Cited by 20 publications

References 59 publications

Fungal-Induced Programmed Cell Death

Fungal-Induced Programmed Cell Death

Editorial: Immunity to Fungal Infections: Insights From the Innate Immune Recognition and Antifungal Effector Mechanisms

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

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