Immunotherapeutic approaches for HPV-caused cervical cancer

Fatemi, Seyed Amirreza; Seifi, Nadia; Rasekh, Shiva; Amiri, Sogand; Moezzi, Seyed Mohammad Iman; Bagheri, Ashkan; Fathi, Shirin; Negahdaripour, Manica

doi:10.1016/bs.apcsb.2021.11.002

Cited by 3 publications

(2 citation statements)

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“…IL-1, IL-6, IL-10, IFN-γ, transforming growth factor beta, and other cytokines have been found to have different trends in different degrees of cervical cancer, which has certain predictive significance for tumor progression and prognosis. [ 7 , 9 , 39 ] Inflammatory factors are important markers for disruption of the cervical epithelial barrier. The cervical epithelial barrier retains the appropriate microbiota to prevent the entry of pathogenic bacteria and viruses into the cervical stroma, which affects the epithelium through the production of metabolites and secreted factors, and induces inflammatory responses and disruption of the epithelial barrier.…”

Section: Discussionmentioning

confidence: 99%

“…Oncogenic proteins encoded by HPV E6/E7 genes are important factors leading to cervical epithelial carcinogenesis. [ 6 , 7 ] The binding and regulation of these 2 proteins by p53 and pRb, 2 major intracellular tumor suppressor proteins, can significantly alter the cell growth cycle, DNA repair, and activation of the cyclooxygenase-2 inflammatory pathway, resulting in increased inflammation and tumorigenesis. [ 8 , 9 ] Therefore, inflammation plays a crucial role in the tumorigenesis of cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

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A bibliometric analysis of global research trends of inflammation in cervical cancer: A review

Kang,

Qiu,

Wei

et al. 2023

Medicine

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Cervical cancer is a common malignant tumor and a leading cause of death in women worldwide. It plays a crucial role in tumorigenesis and progression of cervical cancer. A total of 1606 references on inflammation in cervical cancer were retrieved from the Web of Science Core Collection and visual analysis was performed using VOSviewer. Inflammation in cervical cancer has attracted the attention of researchers. Even though China is the country that publishes the most papers, with the most of the top-ranking institutions, there is no extensive collaboration and exchange of papers by Chinese scholars. PLOS One is a popular journal on inflammation in cervical cancer. Instead, authors from other countries perform better, for example, the Sjoerd H. Van Der Burg is the most widely cited author and “M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4 + Th1 cells” (Moniek Heusinkveld, Leiden University Medical Center) is the most cited article of inflammation in cervical cancer. Keywords associated with “apoptosis,” “HPV,” “NF-κB,” and “oxidative stress have been used in many studies, and keywords associated with “apoptosis,” “human papillomavirus (HPV),” “NF-κB,” and “oxidative stress” are involved in many studies, and there may be more research ideas in the future. From the perspective of precision medicine, more substantive research articles can promote scientific value, strengthen communication and cooperation, produce more extensive research results, and greatly promote the clinical diagnosis and treatment of cervical cancer. All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Section: Discussionmentioning

confidence: 99%