Immunotherapeutic Hydrogel with Photothermal Induced Immunogenic Cell Death and STING Activation for Post‐Surgical Treatment

Wang, Meng; Zhang, Xiaohui; Liu, Bing; Liu, Chen; Song, Caimei; Chen, Yu; Jin, Yu-Bei; Lin, Jing; Huang, Peng; Xing, Shaojun

doi:10.1002/adfm.202300199

Cited by 18 publications

(8 citation statements)

References 64 publications

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“…The effects of the material on immune cells were further studied. Macrophages play an important role in immune response, which could be transformed into two phenotypes of inflammatory promoting type (M1) and inflammatory inhibiting type (M2) under different conditions. − Existing studies have demonstrated that tumors tend to transform into M2-type, which is conducive to tumor progression. Reversing this situation is crucial for tumor immunotherapy.…”

Section: Resultsmentioning

confidence: 99%

“Three Musketeers” Enhances Photodynamic Effects by Reducing Tumor Reactive Oxygen Species Resistance

Xu,

Qian,

Qiao

et al. 2024

ACS Appl. Mater. Interfaces

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Photodynamic therapy (PDT) based on upconversion nanoparticles (UCNPs) has been widely used in the treatment of a variety of tumors. Compared with other therapeutic methods, this treatment has the advantages of high efficiency, strong penetration, and controllable treatment range. PDT kills tumors by generating a large amount of reactive oxygen species (ROS), which causes oxidative stress in the tumor. However, this killing effect is significantly inhibited by the tumor’s own resistance to ROS. This is because tumors can either deplete ROS by high concentration of glutathione (GSH) or stimulate autophagy to eliminate ROS-generated damage. Furthermore, the tumor can also consume ROS through the lactic acid metabolic pathway, ultimately hindering therapeutic progress. To address this conundrum, we developed a UCNP-based nanocomposite for enhanced PDT by reducing tumor ROS resistance. First, Ce6-doped SiO2 encapsulated UCNPs to ensure the efficient energy transfer between UCNPs and Ce6. Then, the biodegradable tetrasulfide bond-bridged mesoporous organosilicon (MON) was coated on the outer layer to load chloroquine (CQ) and α-cyano4-hydroxycinnamic acid (CHCA). Finally, hyaluronic acid was utilized to modify the nanomaterials to realize an active-targeting ability. The obtained final product was abbreviated as UCNPs@MON@CQ/CHCA@HA. Under 980 nm laser irradiation, upconverted red light from UCNPs excited Ce6 to produce a large amount of singlet oxygen (1O2), thus achieving efficient PDT. The loaded CQ and CHCA in MON achieved multichannel enhancement of PDT. Specifically, CQ blocked the autophagy process of tumor cells, and CHCA inhibited the uptake of lactic acid by tumor cells. In addition, the coated MON consumed a high level of intracellular GSH. In this way, these three functions complemented each other, just as the “three musketeers” punctured ROS resistance in tumors from multiple angles, and both in vitro and in vivo experiments had demonstrated the elevated PDT efficacy of nanomaterials.

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Section: Resultsmentioning

confidence: 99%

“Three Musketeers” Enhances Photodynamic Effects by Reducing Tumor Reactive Oxygen Species Resistance

Xu,

Qian,

Qiao

et al. 2024

ACS Appl. Mater. Interfaces

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“…Bilateral 4T1 [77] Ce6 integrated photosensitive cells (ceCyan) 4T1 [78] Chlorella 4T1 [79] Ultrasound Bubble liposomes B16F10 [80] TiO 2 @PTX GL261 [81] X-ray Metal-organic framework (MOF) [19,43,44] Poly (lactic-co-glycolic acid) (PLGA) B16F10 [45] Gd 3+ , 5-GMP, and Hemin CT26 and 4T1 [69] Hydrogels Microwave ablation (MWA) Ca 2+ /Mn 2+ CT-26 [52] X-ray CpG/OxPt CT-26 [54] Near-infrared light (NIR) Metal ion-cyclic dinucleotide Panc02-H7 and 4T1 [82] Nitric Oxide (NO) 4T1 [71] Oxygen (O 2 ) 4T1 [83] ZIF-8, MIT and siIDO1 GL261 [57] Microneedle patches Near-infrared light (NIR) Melanin B16F10 [63] ICG and IDO B16F10 [64] Ce6 B16F10 [65] Catalase (CAT), Zn 2+ , Cu 2+ , and 2-MIM B16F10…”

Section: Other Technologies For the Local Delivery Of Icd Inducersmentioning

confidence: 99%

Local Drug Delivery Techniques for Triggering Immunogenic Cell Death

et al. 2023

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Immunogenic cell death (ICD), a dying state of the cells, encompasses the changes in the conformations of cell surface and the release of damage‐associated molecular patterns, which could initiate an adaptive immune response by stimulating the dendritic cells to present antigens to T cells. Advancements in biomaterials, nanomedicine, and micro‐ and nano‐technologies have facilitated the development of effective ICD inducers, but the potential toxicity of these vesicles encountered in drug delivery via intravenous administration hampers their further application. As alternatives, the local drug delivery systems have gained emerging attention due to their ability to prolong the retention of high payloads at the lesions, sequester drugs from harsh environments, overcome biological barriers to exert optimal efficacy, and minimize potential side effects to guarantee bio‐safety. Herein, a brief overview of the local drug delivery techniques used for ICD inducers is provided, explaining how these techniques broaden, alter, and enhance the therapeutic capability while circumventing systemic toxicity at the same time. The historical context and prominent examples of the local administration of ICD inducers are introduced. The complexities, potential pitfalls, and opportunities for local drug delivery techniques in cancer immunotherapy are also discussed.

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“…Immunostimulants such as TLR agonists and STING agonists [69] have been incorporated into hydrogels for tumor vaccination. Zhu and co-workers reported that single-dose nanovaccine in hydrogel for robust immunotherapy of large tumors.…”

Section: Hydrogel Depots For Cancer Immunotherapymentioning

confidence: 99%

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Zhang,

He,

Chen

2023

Advanced Materials

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The immune system not only acts as a defense against pathogen and cancer cells, but also plays an important role in homeostasis and tissue regeneration. Targeting immune systems is a promising strategy for efficient cancer treatment and regenerative medicine. Current systemic immunomodulation therapies are usually associated with low persistence time, poor targeting to action sites and severe side effects. Due to their ECM‐mimetic nature, tunable properties and diverse bioactivities, hydrogels are intriguing platforms to locally deliver immunomodulatory agents and cells, as well as provide an immunomodulatory microenvironment to recruit, activate and expand host immune cells. In this review, we focus on the design considerations, including polymer backbones, crosslinking mechanisms, physicochemical nature, and immunomodulation‐related components, of the hydrogel platforms. The immunomodulatory effects and therapeutic outcomes in cancer therapy and tissue regeneration of different hydrogel systems are emphasized, including hydrogel depots for delivery of immunomodulatory agents, hydrogel scaffolds for cell delivery, and immunomodulatory hydrogels depending on the intrinsic properties of materials. Finally, the remained challenges in current systems and future development of immunomodulatory hydrogels are discussed.This article is protected by copyright. All rights reserved

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Immunotherapeutic Hydrogel with Photothermal Induced Immunogenic Cell Death and STING Activation for Post‐Surgical Treatment

Cited by 18 publications

References 64 publications

“Three Musketeers” Enhances Photodynamic Effects by Reducing Tumor Reactive Oxygen Species Resistance

“Three Musketeers” Enhances Photodynamic Effects by Reducing Tumor Reactive Oxygen Species Resistance

Local Drug Delivery Techniques for Triggering Immunogenic Cell Death

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

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