Immunotherapy

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are one of the most common cancers worldwide. A large number of patients are diagnosed with locally advanced disease and require multimodal treatment approaches. Standard treatment modalities ranging from surgery to chemotherapy and radiation are yielding mixed results. To overcome this hurdle, newer innovative approaches are required to reduce the morbidity and mortality of the patients. In the last few decades, immunotherapy has become an important part of treating some types of cancer. The immune system plays a key role in the development, establishment and progression of HNSCC. A greater understanding of the dysregulation and evasion of the immune system in the evolution and progression of HNSCC provides the basis for improved therapies and outcomes for patients. Newer types of immune treatments are now being studied, and they will impact how we treat cancer in the future. This article provides a brief overview of the current immunotherapeutic strategies for cancer with emphasis on HNSCC.

Nanocarrier-Integrated Microneedles: Divulging the Potential of Novel Frontiers for Fostering the Management of Skin Ailments

“…Nowadays, immunotherapy has grabbed the prodigious attention of scientists for the treatment of cancer. Immunotherapy demonstrates an antitumor effect by stimulating the inherent immune system of the host to fight against tumor cells . Currently, cancer vaccines, adoptive T-cell transfer, immune checkpoint inhibitors, immunomodulation, and targeted antibody therapies are considered as popular immunotherapy approaches for cancer management.…”

“…Immunotherapy demonstrates an antitumor effect by stimulating the inherent immune system of the host to fight against tumor cells. 221 Currently, cancer vaccines, 222 adoptive T-cell transfer, 223 immune checkpoint inhibitors, 222 immunomodulation, 224 and targeted antibody therapies 225 are considered as popular immunotherapy approaches for cancer management. However, ineffectiveness in eradication of solid tumors, immune-related side effects, and high cost are the major hurdles faced during immunotherapy.…”

Exploring novel immunotherapy biomarker candidates induced by cancer deformation

“…Monoclonal antibodies, a significant advancement made possible by the pioneering work of Milstein and Köhler in the 1970s, have revolutionized this field [ 11 ]. They are engineered to specifically target antigens and can be produced at a large scale, playing a pivotal role in modern immunotherapy [ 12 ].…”

Exploring the Role and Prognostic Value of TMEM208 in Head and Neck Squamous Cell Carcinoma

“…Common treatments for HNSCC include surgical treatment, chemotherapy, radiotherapy, and combination therapy [3]. With the deepening of research, immunotherapy, especially immune checkpoint inhibitors (ICI), has gradually entered the Exploring the Role and Prognostic Value of TMEM208 in Head and Neck Squamous Cell Carcinoma public eye and become an important part of treatment [5].…”