Immunotherapy and Radiotherapy Combination

Sarıhan, Süreyya

doi:10.32708/uutfd.710919

Uludağ Üniversitesi Tıp Fakültesi Dergisi

2020

DOI: 10.32708/uutfd.710919

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Immunotherapy and Radiotherapy Combination

Süreyya Sarıhan

Abstract: ÖZET İmmunoterapi, bağışıklık sisteminin güçlendirilmesi ile birçok kanser türünde yanıt, yanıt süresi ve sağkalım açısından etkinliği kanıtlanmış bir tedavidir. Yanıt oranları %20 olup dirençli hastalarda immunoterapi ile sinerjik etki yaratan yeni tedavilere gereksinim vardır. Radyoterapi ile tümör hücrelerinden salınan antijenik uyarı tümörün bağışıklık sistemi tarafından daha kolay tanınmasını sağlayarak immunoterapinin tamamlayıcısı olabilir. Radyoterapinin, ışınlanan hedef dışındaki metastazlar üzerindek… Show more

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2022

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Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

Ocak

Sarıhan

Şahin

et al. 2022

Turkish Journal of Internal Medicine

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BackgroundIn non-small cell lung cancer (NSCLC), immunotherapy is a treatment option in patients without targetable mutations in second and later lines. Nevertheless, there is no validated test that can predict immunotherapy response. Material and MethodsOur study aimed to investigate the effect of radiotherapy (RT) on survival in patients with NSCLC receiving immunotherapy after first-line chemotherapy. Twenty-five patients diagnosed with NSCLC and received immunotherapy after at least one previous chemotherapy line were included in our study. ResultsThe median age of the patients was 61.7 (26.6-81.2) years. 19 (76%) patients were male. 11 (44%) of the patients had received immunotherapy in the second-line and 14 (66%) in ≥3 lines. Patients had received a median of 5 cycles (1-27) of immunotherapy. RT to immunotherapy interval was 6.4 months (1.0-11.8). Partial response was observed in 12 patients, stable disease in 8 patients, progression in 1 patient, and hyperprogression in 4 patients. Median progression-free survival (PFS) was 4.4 months (95% CI; 3.2-5.6), and median overall survival (OS) was 16.4 months (95% CI; 5.6-27.3). 14 (56%) of the patients had received RT. RT was administered to 12 patients before immunotherapy, and two patients received RT to bones during immunotherapy. The patients who received RT had statistically longer PFS (4.9 vs 3.9 months, p=0.012) and OS (18.7 vs 7.3 months, p=0.023) comparing those without RT. Conclusions Our findings showed that RT significantly improved the survival in patients who received immunotherapy, pointing that RT may have an influential role in immunotherapy response.

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Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

Ocak

Sarıhan

Şahin

et al. 2022

Turkish Journal of Internal Medicine

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Immunotherapy and Radiotherapy Combination

Cited by 1 publication

References 100 publications

Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

Radiotherapy could increase the efficacy of immunotherapy in non-small cell lung cancer

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