Immunotherapy and Therapeutic antibodies

Gupta, Mayank; A, Boraste; K, Vamsi Krishna; Khairnar, Yogesh; Joshi, B C; Gupta, Girish; Patil, Prasad; Trivedi, S K; Gupta, Nikhil; AK, Mujapara; Amol, Jadhav

doi:10.9735/0975-2943.1.2.41-49

Cited by 1 publication

(1 citation statement)

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“…Regarding combined treatments of TN with another agent, some studies have evaluated the combination with topical Ciclopirox, concluding that the combination therapy of oral TN and Ciclopirox nail lacquer is a safe and more effective treatment for onychomycosis than TN alone, 42 especially in younger patients and in shorter-duration onychomycosis. 43 There are also studies with Amorolfine showing that in the treatment of toenail onychomycosis with matrix involvement, Amorolfine nail lacquer in combination with oral TN enhances clinical efficacy and is more cost-effective than TN alone.…”

Section: Discussionmentioning

confidence: 99%

Methylene blue vs methyl aminolevulinate photodynamic therapy in combination with oral terbinafine in the treatment of severe dermatophytic toenail onychomycosis: Short‐ and long‐term effects

Alberdi¹,

Gómez

2020

Mycoses

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Background Photodynamic therapy (PDT) kills target microorganisms via reactive oxygen species (ROS) production. PDT seems to be a good alternative treatment option for onychomycosis. Objective To compare the efficacy of combined therapies based on oral terbinafine (TN) plus adjunctive PDT mediated by methylene blue (MB) (TN + MB/PDT) or methyl aminolevulinate (MAL) (TN + MAL/PDT) in the treatment of onychomycosis. Methods Twenty patients affected by severe dermatophyte onychomycosis in the nails of the big toe (>60% disease involvement of target nail) received oral TN for 12 weeks and concomitantly were randomly allocated to receive nine sessions, separated by 2‐week intervals, of urea (40%) plus a PDT protocol mediated by MB (TN + MB/PDT: group I) or mediated by MAL (TN + MAL/PDT: group II). Clinical and mycological efficacy was evaluated at 16‐, 40‐ and 52‐week follow‐up. Results Both protocols showed a significant decrease in Onychomycosis Severity Index (OSI) scores (P < .05), from 24.2 ± 4.6 to 0.7 ± 0.6 (group I)) and from 18.5 ± 10.1 to 2.1 ± 2.0 (group II). No side effects or complications were reported in any of the combinations used. Mycological cure rates were significantly higher during the last third of the evaluated period of time, reaching 100% and 90% in group I and group II, respectively, at the 52‐week follow‐up. In both modalities, complete cure was achieved in 70% of the patients at the 52‐week follow‐up. Conclusions TN + MB/PDT and TN + MAL/PDT show similar outcomes in the treatment of toenails with severe onychomycosis. PDT is an effective method to accelerate the TN‐mediated healing process.

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Section: Discussionmentioning

confidence: 99%