2020
DOI: 10.1634/theoncologist.2020-0035
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Immunotherapy in Underrepresented Populations of Patients with Cancer: Do We Have Enough Evidence at Present? A Focus on Patients with Major Viral Infections and Autoimmune Disorders

Abstract: The safety and activity of immune checkpoint inhibitors have been characterized in interventional and observational studies. However, only small studies have specifically investigated these agents in patients who are excluded or underrepresented in clinical trials, frequently referred to as “special populations” or “underrepresented populations.” These include older adults, those with dysregulated immune activation, patients with a compromised immune function, and those carrying major viral infections, lymphop… Show more

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Cited by 4 publications
(1 citation statement)
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“…Furthermore, clinical trials that study these new therapies do not include the enrollment of underrepresented patients from the so-called special population made up of elderly patients, [4] or patients with co-morbidities such as major infections (hepatitis B virus, hepatitis C virus, or HIV), preexisting autoimmune diseases of any kind, solid transplant recipients, or patients with lymphoproliferative disease or receiving transplant for hematological malignancy [2 ▪ ,5 ▪ ,6].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, clinical trials that study these new therapies do not include the enrollment of underrepresented patients from the so-called special population made up of elderly patients, [4] or patients with co-morbidities such as major infections (hepatitis B virus, hepatitis C virus, or HIV), preexisting autoimmune diseases of any kind, solid transplant recipients, or patients with lymphoproliferative disease or receiving transplant for hematological malignancy [2 ▪ ,5 ▪ ,6].…”
Section: Introductionmentioning
confidence: 99%