2021
DOI: 10.1177/23247096211009400
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Immunotherapy-Induced Sarcoid-Like Reaction: A Shrewd Imitator

Abstract: A 40-year-old male with a right-sided neck mass was diagnosed with metastatic melanoma. A repeat positron-emission tomography after treatment with combination immunotherapy demonstrated increased hypermetabolic activity in the right supraclavicular, hilar, and mediastinal regions. Immunotherapy was discontinued and a BRAF/MEK inhibitor combination was started. Repeat imaging showed a decrease in size of the neck mass; however, hilar and mediastinal lymph nodes increased in size. A fine needle aspiration of med… Show more

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Cited by 4 publications
(2 citation statements)
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“…Early recognition of such side effects is important as they often mimic disease recurrence and/or consequently may lead to cessation of therapy (Figure 13). 24 Lymph nodes are classically well circumscribed with homogenous CT attenuation and may have calcification in chronic cases. Involvement of other organs such as liver, spleen, and bones can assist in suggesting a diagnosis of sarcoidosis but may also lead to misinterpretation as metastatic disease.…”
Section: Pitfalls Of Mediastinal Entities On Pet/ctmentioning
confidence: 99%
“…Early recognition of such side effects is important as they often mimic disease recurrence and/or consequently may lead to cessation of therapy (Figure 13). 24 Lymph nodes are classically well circumscribed with homogenous CT attenuation and may have calcification in chronic cases. Involvement of other organs such as liver, spleen, and bones can assist in suggesting a diagnosis of sarcoidosis but may also lead to misinterpretation as metastatic disease.…”
Section: Pitfalls Of Mediastinal Entities On Pet/ctmentioning
confidence: 99%
“…It is observed in 4.4% of carcinomas, 7.3% of non-Hodgkin's lymphomas and 13.8% of Hodgkin's disease [ 3 ]. It may also be observed as a side effect of immunotherapy in this group of patients [ 4 ].…”
Section: Introductionmentioning
confidence: 99%