Immunotoxicity activity of natural furocoumarins from milky sap ofFicus caricaL. againstAedes aegyptiL.

Abstract

Ficus carica L., its fruits are delicious and can be eaten by human. Its leaves are commonly used to cure hemorrhoid and clear away heart ache. The milky sap of F. carica have a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an lethal concentration (LC(50)) value of 10.2 μg/ml and an LC(90) value of 42.3 μg/ml. Two natural furocoumarins, 5-methoxypsoralen and 8-methoxypsoralen were isolated from the milky sap of F. carica. The LC(50) value of 5-methoxypsoralen and 8-methoxypsoralen were 9.4 and 56.3 μg/ml, respectively. The above indicates that major compounds may play a more important role in the toxicity of the milky sap of F. carica.

Traditional uses, phytochemistry and pharmacology ofFicus carica: A review

“…The milky sap of Ficus carica was found to be significant toxic action against early fourth-stage larvae of Aedes aegypti with a lethal concentration LC 50 value of 10.2 mg/ml and an LC 90 value of 42.3 mg/ml (Chung et al, 2011). Two natural furocoumarins, namely 5-methoxypsoralen and 8-methoxypsoralen, were isolated from the milky sap of Ficus carica.…”

Nutritional and pharmacological importance of Ficus carica - A review

“…Two furocoumarins, 5-methoxypsoralen and 8-methoxypsoralen, were isolated from the milky sap of Ficus carica, their LC 50 values were 9.4 and 56.3 mg/ml, respectively [90].…”

„Azon orvosságok kezdete, melyeket a májra adnak”

“…A füge fiatal hajtása, tejnedve fitofotodermatitist kiváltó lineáris furanokumarinokat tartalmaz -xantotoxol, bergaptén és pszoralén (ficusin) -, amelyek hatására a bőrre került nö-vényi nedvek napfény jelenlétében súlyos bőrelváltozást okoznak. A fügében ezenkívül található még olyan természetes hidroxi-kumarin-származék, az umbelliferon, amely spasmolyticus hatású, vagy olyan furanokumarinok (5-metoxipszoralén és 8-metoxipszoralén), amelyek az Aedes aegypti szúnyog lárvájának a kifejlődését is ké-pesek megakadályozni [29], ami által a májtüneteket is okozó sárgaláz megelőzhető, hiszen kórokozóját a szú-nyog terjeszti.…”