Immunotoxicity of Bis(tri-n-butyltin)oxide in the rat: Effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats

Vos, J.G.; Klerk, Arja de; Krajnc, E.I.; Loveren, Henk Van; Rozing, Jan

doi:10.1016/0041-008x(90)90366-3

Cited by 156 publications

(53 citation statements)

References 18 publications

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“…However, exposure to TBTO does not unfailingly cause suppression of the DTH. For example, Smialowicz et al (1990) exposed male Fischer 344 rats to 2.5 to 15 mg TBTO/kg BW by oral gavage for 10 days and Vos et al (1990) fed male SPF-derived Wistar rats diets containing 0.5 to 50 ppm TBTO (approximately 0.025 to 2.5 mg/kg BW/day) for 6 or 15 months. No statistical changes in the DTH response were observed in either study.…”

Section: Discussionmentioning

confidence: 99%

“…Reduction in lymphoid organ weights (Seinen et al, 1977a(Seinen et al, , 1977bVos et al, 1990), thymus atrophy (Seinen and Willems, 1976;Seinen, 1980;Miller et al, 1983;Penninks et al, 1985;Pieters et al, 1994Pieters et al, , 1995aPieters et al, , 1995bDeSantiago and Aguilar-Santelises, 1999), lymphocytotoxicity (Seinen, 1980;Penninks and Seinen, 1984;Snoeij et al, 1985), and suppression of natural killer cell function (Vos et al, 1984;Whalen et al, 1999) are just a few of the reported effects of organotins on the immune system or on immune cells in vitro. However, these previous studies administered organotins via gavage or diet; none of the published studies evaluated immune function of animals exposed to organotins in their drinking water.…”

Section: Introductionmentioning

confidence: 99%

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Immune Responses in Sprague–Dawley Rats Exposed to Dibutyltin Dichloride in Drinking Water as Adults

DeWitt

Copeland

Luebke

2005

Journal of Immunotoxicology

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Organotins are used commercially as agricultural pesticides, antifouling agents, and stabilizers for polyvinyl chloride (PVC) pipe. Mono-and di-substituted methyl and butyltins, used in PVC pipe production, are of concern as they leach from supply pipes into drinking water and have been reported to cause multisystem toxicity, including immunotoxicity. As part of an ongoing study to evaluate immunotoxic effects of organotins, we assessed immune function in adult Sprague-Dawley (CD) rats after exposure to dibutyltin dichloride (DBTC). Individually-housed adult male and female CD rats were given drinking water containing 0, 10, or 25 mg DBTC/L (final concentration) in 0.5% Alkamuls for 28 days. Water bottles were changed and water consumption was monitored twice weekly and body weights (BW) were recorded weekly. Delayed-type hypersensitivity (DTH), primary and secondary antibody responses to sheep red blood cells, and natural killer (NK) cell activity were evaluated in separate groups of treated and control animals on day 29 of exposure. Water consumption was significantly decreased in both sexes at 25 mg DBTC/L. BW, immune organ weights, the DTH response, and NK cell activity did not vary by dose. Different results for antibody responses in male rats were obtained in two experimental replicates. In the first replicate, IgG was elevated at the highest dose whereas in the second replicate, IgM was suppressed. However, as these effects occurred at the high dose of 25 mg DBTC/L, which is a concentration a million times higher than levels of DBTC reported in drinking water, our data suggest that DBTC is unlikely to cause immunotoxicity at concentrations found in drinking water supplies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Immune Responses in Sprague–Dawley Rats Exposed to Dibutyltin Dichloride in Drinking Water as Adults

DeWitt

Copeland

Luebke

2005

Journal of Immunotoxicology

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“…Dabei erwiesen sich Infektionsmodelle mit Bakterien und Parasiten, wie Listeria monocytogenes bzw. Trichinella spiralis, als besonders empfindlich (Verdier et al 1991;Vos et al 1990 ). Die Untersuchungen zur Wirkung der n-Butylzinnverbindungen nach wiederholter oraler Verabreichung sind in Tabelle 3 dargestellt.…”

Section: Orale Aufnahmeunclassified

n‐Butylzinnverbindungen [MAK Value Documentation in German language, 2008]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 44. Lieferung, Ausgabe 2008 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Auge Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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“…In rodents, for example, this organotin compound causes a marked thymus atrophy due to reduction in the number of cortical thymocytes and this leads to a reduced immune response (Snoeij et al, 1988;Bressa et al, 1991;De Wall et al, 1993, 1997, which is manifested through a suppressed: delayed-type hypersensitivity response; infection resistance; and, antibody response (Snoij et al, 1987;Boyer, 1989;Bressa et al, 1991;Schuurman et al, 1992). Further, TBTO can also affect non-specific immune functions such as macrophage (Vos et al, 1984) and natural killer (NK) cell activity Vos et al, 1990;Alouch et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)

Osman¹,

Kol²,

Peijnenburg³

et al. 2009

Journal of Immunotoxicology

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Immunotoxicity of Bis(tri-n-butyltin)oxide in the rat: Effects on thymus-dependent immunity and on nonspecific resistance following long-term exposure in young versus aged rats

Cited by 156 publications

References 18 publications

Immune Responses in Sprague–Dawley Rats Exposed to Dibutyltin Dichloride in Drinking Water as Adults

Immune Responses in Sprague–Dawley Rats Exposed to Dibutyltin Dichloride in Drinking Water as Adults

n‐Butylzinnverbindungen [MAK Value Documentation in German language, 2008]

Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)

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