Immunotoxicity of pentachlorophenol (PCP): Increased susceptibility to tumor growth in adult mice fed technical PCP-contaminated diets

Kerkvliet, Nancy I.; Baecher-Steppan, L; Schmitz, J. A.

doi:10.1016/0041-008x(82)90101-6

Cited by 57 publications

(25 citation statements)

References 13 publications

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“…However, despite the evidence that PCB-induced immunosuppression impairs immune surveillance, Aroclor 1254 was shown to protect mice and rats (shown as reduced tumor growth and metastasis) against certain kinds of experimentally induced tumors including the Ehrlich's tumor ascites and the primary Walker 256 tumor (43,44). This paradox points to the need for additional studies on PCB-induced carcinogenesis.…”

Section: Discussion and Summarymentioning

confidence: 92%

“…In contrast to Aroclor 1260, the immunomodulating effects of Aroclor 1254 have been studied in rodents and in rabbits by a number of investigators (34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) Exposure of male rats to Aroclor 1254 in feed also resulted in a number of significant effects on humoral and cell-mediated immune parameters. Talcott et al (37,38) and Exon (39) fed Aroclor 1254 at doses of 50 or 500 ppm to male rats for 10 weeks.…”

Section: Mechanisms Of Immunotoxicitymentioning

confidence: 99%

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Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes.

Tryphonas

1995

Environ Health Perspect

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Polychlorinated biphenyls (PCBs) are among the most widespread environmental pollutants and a prominent contaminant of the Great Lakes basin. Due to their resistance to biodegradation and lipophilic properties, PCBs bioaccumulate in fish tissues and in fish-eating humans. PCBs are also known to cross the placenta and to be excreted into the mother's milk, thus predisposing the infant to potentially adverse health effects. For example, a higher incidence of bacterial infections was reported for breast-fed infants born to mothers who consumed large amounts of Great Lakes fish compared to the incidence in control infants whose mothers ingested low amounts of fish. While data regarding the PCB-induced immunotoxic effects in humans are scarce, data derived from the use of experimental animals, including nonhuman primates, indicate that the immune system is a potential target for the immunotoxic effects of PCBs. Such studies have used the commercially available PCB mixtures alone. However, PCBs have the potential of partially antagonizing the effects of other structurally related compounds including the highly toxic dioxins, which are also present in small amounts in the Great Lakes. Thus, to fully evaluate the magnitude of the immunotoxic risk PCBs pose to humans, consideration should be given to investigations in which the interactive effects of PCBs are combined with other contaminants present in the Great Lakes.

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Section: Discussion and Summarymentioning

confidence: 92%

Section: Mechanisms Of Immunotoxicitymentioning

confidence: 99%

Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes.

Tryphonas

1995

Environ Health Perspect

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“…injection of relatively high doses of .TCDD without a concurrent effect on their cytotoxic activity (117). In contrast, mice fed PCDD-contaminated PCP had normal numbers of resident peritoneal macrophages, and their recruitment following thioglycollate or P815 tumor injection was not altered (79). Increased numbers of resident peritoneal macrophages were reported in rats exposed to PCDD-contaminated PCP (32).…”

Section: Exon Kerkvliet and Talcottmentioning

confidence: 93%

Immunotoxicity of carcinogenic pesticides and related chemicals

Exon

Kerkvliet

Talcott

1987

Environmental Carcinogenesis Reviews

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“…Recently studies have shown that the contaminating formation products of PCP are immunotoxic and capable of affecting acquired immune responses [5][6][7]. KERKVLIET et al demonstrated that when incorporated in the diet of mice, Technical Grade PCP produced a dosedependent suppression in various humoral immune response parameters [5] as well as depressing T-cell cytolytic activity and enhancing tumor susceptibility [6].…”

Section: Introductionmentioning

confidence: 99%

Suppression of mouse complement activity by contaminants of technical grade pentachlorophenol

White

Anderson

1985

Agents and Actions

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Pentachlorophenol (PCP) is an antimicrobial agent used chiefly for the preservation of wood. Subchronic oral exposure (14 days) to Technical Grade PCP significantly inhibited the functional activity of female B6C3F1 mouse complement when measured in a microtiter hemolytic assay. When evaluated one day following the final exposure the highest administered dose (100 mg/kg) significantly suppressed the Classical complement pathway, the Spontaneous C1 autoactivation pathway, the Alternate pathway and the level of complement component, C3. Reconstitution studies using C5-deficient serum also demonstrated deleterious effects on this complement component. The Classical pathway was the most sensitive to Technical Grade PCP effects. Animals treated with 100 mg/kg Technical Grade PCP had CH 50 levels 30% of vehicle controls. Animals treated for 14 days and allowed a 15 day recovery period had CH 50 values 36% of control and animals which recovered for 30 days had only 52% of the complement activity of control animals. C3 recovery studies also demonstrated continued suppression on days 15 and 30 post-final exposure. Doses of 10 and 30 mg/kg did not produce the marked effects observed with the highest dose; however, a dose-dependent trend was observed for all responses. Animals treated with 100 mg/kg of EC-7, a PCP preparation with reduced amounts of contaminating dioxins and dibenzofurans, did not demonstrate detrimental effects on the complement system.

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Immunotoxicity of pentachlorophenol (PCP): Increased susceptibility to tumor growth in adult mice fed technical PCP-contaminated diets

Cited by 57 publications

References 13 publications

Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes.

Immunotoxicity of PCBs (Aroclors) in relation to Great Lakes.

Immunotoxicity of carcinogenic pesticides and related chemicals

Suppression of mouse complement activity by contaminants of technical grade pentachlorophenol

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