Immunotoxicity of pentachlorophenol to a marine bivalve species and potential toxification mechanisms underpinning

Zhang, Weixia; Tang, Yu; Han, Yu; Huang, Lin; Zhou, Weicheng; Zhou, Chaosheng; Hu, Yuan; Lu, Rongmao; Wang, Fang; Shi, Wei; Liu, Guangxu

doi:10.1016/j.jhazmat.2022.129681

Cited by 30 publications

(3 citation statements)

References 110 publications

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“…6,7 Besides, pentachlorophenol (PCP) is widely used in agriculture as an important preservative, which is toxic and carcinogenic to human health. 8,9 At present, many detection methods are developed for the determination of nitrophenols and PCP, such as surface-enhanced Raman spectroscopy, 10 high-pressure liquid chromatography (HPLC), 11 electrochemical methods, 12,13 gas chromatography (GC), 14 etc. Nevertheless, some of them still present shortcomings of complicated operation, long detection time, and high cost.…”

Section: ■ Introductionmentioning

confidence: 99%

“…However, the high toxicity and low degradable characteristics of phenols make them highly susceptible to polluting the ecological environments. Many phenolic compounds have been listed as priority pollutants by the European Union (EU) and the US Environmental Protection Agency (EPA), including nitrophenol, chlorophenol, and aminophenol. − As one of the common pollutants in chemical wastewater, nitrophenol compounds can cause serious harm to human health and the natural environment. , Besides, pentachlorophenol (PCP) is widely used in agriculture as an important preservative, which is toxic and carcinogenic to human health. , At present, many detection methods are developed for the determination of nitrophenols and PCP, such as surface-enhanced Raman spectroscopy, high-pressure liquid chromatography (HPLC), electrochemical methods, , gas chromatography (GC), etc. Nevertheless, some of them still present shortcomings of complicated operation, long detection time, and high cost.…”

Section: Introductionmentioning

confidence: 99%

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Amino-Functionalized NDI-Based MOFs as Unusual “Turn On” and “Turn Off” Fluorescent Sensors for Phenolic Pollutants with Double Solvent Channel Response and Iodine Adsorbents

Jiang,

Zhang,

Jin

et al. 2024

Inorg. Chem.

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Regulating mixed ligands to change the functional properties of metal−organic frameworks (MOFs) has been an important topic; especially, the structural changes have significant implications for the transformation of sensing response in different solvent channels. Herein, two [Cd (DPNDI) (NH 2 -BDC) 0.5 (NO 3 )]•2.25DMF (1) and [Cd(DPNDI)(NH 2 -AIPA)]• 0.5DMF (2) (DPNDI = N,N-di(4-pyridyl)-1,4,5,8-naphthalenetetracarboxydiimide, NH 2 -BDC = 2-amino terephthalic acid, NH 2 -AIPA = 5-aminoisophthalic acid) were synthesized by the solvothermal method. Structural analysis shows that complex 1 has a two-dimensional planar network structure and complex 2 exhibits a three-dimensional network structure, endowing its potential as an efficient fluorescence sensor for phenolic compound detection under different solvent environments. Both complexes showed high fluorescence quenching sensitivity to phenolics in a water medium. Conversely, complex 1 showed a fluorescence enhancement response to phenolic pollutants in an ethanol system with significantly low detection limits and recyclability. The detection limits were 0.58 μM for TNP, 1.3 μM for DNP, and 2.43 μM for PCP. In addition, the uncoordinated amino groups in the complexes promote them to exhibit excellent iodine adsorption performance. Especially, complex 2 can serve as an adsorbent for iodine in cyclohexane solution with better adsorption efficiency than that of complex 1, and its adsorption capacity can reach 505 mg/g. The mixed ligands regulation strategy of NDI-based MOFs will open up an effective avenue for the conversion of fluorescence signals in dual-solvent channels and play simultaneously important roles in multiple applications.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Amino-Functionalized NDI-Based MOFs as Unusual “Turn On” and “Turn Off” Fluorescent Sensors for Phenolic Pollutants with Double Solvent Channel Response and Iodine Adsorbents

Jiang,

Zhang,

Jin

et al. 2024

Inorg. Chem.

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“…In recent decades, Pentachlorophenol (PCP) and its soluble PCP sodium salt (PCP-Na) have been produced commercially as active ingredients in herbicides, silicides, wood preservatives, fungicides, and bactericides. Their release into the environment has toxic effects on ecosystems [1,2]. China uses PCP and its sodium salt to eradicate parasitic schistosomes in paddy fields and ponds, where they are used in large quantities.…”

Section: Introductionmentioning

confidence: 99%

Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk

Yan,

Zhao,

Yan

et al. 2023

Molecules

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Pentachlorophenol (PCP) has attracted wide attention due to its high toxicity, persistence, and bioaccumulation. In this study, a sensitive UPLC-MS/MS method for the determination of PCP in seafood samples was developed and validated. The samples were ultrasonic extracted with acetonitrile containing 1% acetic acid-acetonitrile and followed by using a pass-through solid-phase extraction (SPE) cleanup on Captiva EMR-Lipid cartridges. The linearity of this method ranged from 1 to 1000 μg/L, with regression coefficients of >0.99. The detection limit and quantitation limit were 0.5 μg/kg and 1.0 μg/kg, respectively. The recoveries in different types of seafood samples ranged from 86.4% to 102.5%, and the intra-day and inter-day relative standard deviations (RSDs) were 3.7% to 11.2% and 2.9% to 12.1%, respectively (n = 6). Finally, the method has been successfully utilized for the screening of PCP in 760 seafood samples from Zhejiang Province. PCP was detected in 5.8% of all seafood samples, with the largest portion of detections found in shellfish, accounting for approximately 60% of the total. The average concentrations detected ranged from 1.08 to 21.49 μg/kg. The non-carcinogenic risk indices for adults and children who consume PCP ranged from 10−4 to 10−3 magnitudes. All of these indices stayed significantly below 1, implying that the health risk from PCP in marine organisms to humans is minimal.

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Pentachlorophenol Exposure Delays the Recovery of Colitis in Association With Altered Gut Microbiota and Purine Metabolism

Li,

Mu,

et al. 2024

Environmental Toxicology

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Pentachlorophenol (PCP) was used widely as preservative and biocide and has been banned due to with various harmful effects, such as carcinogenicity and teratogenicity. However, the effects of PCP on colitis induced by dextrose sodium sulfate (DSS) remain largely unknown. Serum metabolomics and gut microbiota were investigated to elucidate the underlying mechanisms. Exposure to 20 μg/L PCP aggravated DSS‐induced body weight loss, colon shortening, severe histological injuries, and upregulation of TNFα, iNOS, IL‐1β, and IL‐6. Serum metabolomics showed that both DSS and PCP could significantly disrupted tryptophan metabolism in normal mice. Interestingly, PCP exposure intensified the disturbance in purine metabolism but not tryptophan metabolism caused by DSS. Quantitative analysis of tryptophan and metabolites further confirmed that PCP exposure significantly increased the serum contents of serotonin, adenine, guanine, guanosine, inosine monophosphate (IMP), inosine, and hypoxanthine in DSS‐treated mice. The overall gut microbial community was significantly modified by PCP and DSS treatment alone. Rikenellaceae_RC9_Gut_group, Colidextribacter, and Desulfovibrio were more abundant in colitis mice following PCP exposure. Further integrative analysis of differential bacteria and purine metabolites highlighted a significant correlation between Desulfovibrio and several purine metabolites, including guanine, guanosine, hypoxanthine, IMP, and inosine. Adenosine ribonucleotides de novo biosynthesis, inosine‐5′‐phosphate biosynthesis I, and urate biosynthesis/inosine 5′‐phosphate degradation pathways were depleted in colitis mice upon PCP treatment. Taken together, PCP exposure delayed the recovery of colitis induced by DSS in association with altered gut microbiota and serum metabolites, which were enriched in tryptophan and purine metabolism.

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Immunotoxicity of pentachlorophenol to a marine bivalve species and potential toxification mechanisms underpinning

Cited by 30 publications

References 110 publications

Amino-Functionalized NDI-Based MOFs as Unusual “Turn On” and “Turn Off” Fluorescent Sensors for Phenolic Pollutants with Double Solvent Channel Response and Iodine Adsorbents

Amino-Functionalized NDI-Based MOFs as Unusual “Turn On” and “Turn Off” Fluorescent Sensors for Phenolic Pollutants with Double Solvent Channel Response and Iodine Adsorbents

Determination of Pentachlorophenol in Seafood Samples from Zhejiang Province Using Pass-Through SPE-UPLC-MS/MS: Occurrence and Human Dietary Exposure Risk

Pentachlorophenol Exposure Delays the Recovery of Colitis in Association With Altered Gut Microbiota and Purine Metabolism

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