Immunotoxicity pathway and mechanism of benzo[a]pyrene on hemocytes of Chlamys farreri in vitro

Lei, Fengjun; Tian, Yimeng; Miao, Jingjing; Pan, Luqing; Tong, Ruixue; Zhou, Yong

doi:10.1016/j.fsi.2022.04.009

Cited by 8 publications

(2 citation statements)

References 80 publications

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“…Phagocytosis against external infection factors also occurs in other bivalves. For example, Lei et al (2022) found that ctenophore scallops are highly phagocytic against Escherichia coli and Staphylococcus aureus . Significant upregulation of ATPeV1E, ATPeV1C, ATPeV1H and other proteins can regulate not only phagocytosis but also mTOR pathway.…”

Section: Discussionmentioning

confidence: 99%

Morphological change and differential proteomics analysis of gill in Mytilus coruscus under starvation

Liang

Zhang

et al. 2023

Front. Physiol.

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Mytilus coruscus is a dominant shellfish in the Yangtze estuary and its adjacent sea area. Food deprivation often occurs during their growth due to fluctuations in algal abundance caused by seasonal freshwater flushing and high-density aquaculture mode. To investigate the coping strategies of M. coruscus to starvation stress, electron microscopy and differential proteomic analysis were performed on the critical feeding organ gill of the mussels after 9 days of starvation. The electron microscopy results showed that the cilia of the mussel gills were dissolved, and the gaps between gill filaments widened under starvation. Differential proteomic analysis revealed that phagocytosis-related proteins such as ATPeV1E, ATPeV1C, LAMP1_2 and CTSL were significantly upregulated, and the phagocytosis pathway was significantly enriched (p < 0.05). In addition, the corin content in gill and myeloperoxidase level as well as the number of dead cells in blood were both significantly increased (p < 0.05). What’s more, proteomic data suggested that immune maintenance, cellular transport and metabolism related pathways were significantly enriched, which illustrated an immune and metabolism responses under starvation. This study reveals for the first time that phagocytosis functions as an essential strategy for M. coruscus to cope with starvation, which provides new scientific knowledge and a theoretical basis for understanding the adaptation mechanisms of mussel to starvation and for rational optimization of mussel culture patterns.

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Section: Discussionmentioning

confidence: 99%

Morphological change and differential proteomics analysis of gill in Mytilus coruscus under starvation

Liang

Zhang

et al. 2023

Front. Physiol.

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“…Бенз(а)пирен -высокотоксичный полициклический углеводород (ПАУ) с выраженными цитотоксическими, мутагенными, канцерогенными и нейротоксическими свойствами [10]. Механизмы реализации мутагенных и канцерогенных свойств бенз(а)пирена основываются на ковалентном связывании его метаболита -бенз(а)пирен-7,8-дигидродиол-9,10-эпоксида (BPDE) с нуклеотидными основаниями и последующим формированием цис-и транс-аддуктов ДНК, что вызывает повреждения нуклеотидной последовательности, нарушения процессов репарации и репликации, трансформацию клетки и, как следствие, ее гибель и / или канцерогенез [11,12].…”

Section: т а б л и ц аunclassified

Polymorphism of TP53 (rs1042522) gene and peculiarities of the immune profile in children exposed to airborne benzo(a)pyrene

Dolgikh,

Nikonoshina

2024

Health Risk Analysis

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Examining peculiarities of an immune profile and genetic polymorphisms is especially relevant when identifying markers of effect and sensitivity to exposure to benzo(a)pyrene in northern areas. We examined 1253 children who lived in industrial centers and on conditionally clean territories in the north and south of Eastern Siberia. Levels of benzo(a)pyrene in ambient air and in children’s blood were determined by using HPLC. TP53 (rs1042522) polymorphism was examined by using real-time PCR; p53 levels were identified with flow cytofluorometry; IgG to benzo(a)pyrene, by the radioallergosorbent tests. Exposure of children in Northern Siberia to airborne benzo(a)pyrene at the dose of 7.11•10-3 µg/(kg•day) causes ben-zo(a)pyrene contamination in blood, activates apoptosis (p53) and stimulates occurrence of specific sensitization (IgG to benzo(a)pyrene) (p < 0.05). Similar disorders were established in children in Southern Siberia under exposure to airborne benzo(a)pyrene at the dose of 86.46•10-3 µg/(kg•day). The detected changes in immune profiles of children living in Northern Siberia are associated with G-allele and GG-genotype (rs1042522) of the TP53 gene (OR = 1.37–1.83, p < 0.05); children in Southern Siberia, С-allele and СС-genotype of the said gene (OR = 1.55–2.38, p < 0.05). Therefore, the immune profile of children exposed to airborne benzo(a)pyrene at the dose of 7.11•10-3 µg/(kg•day) in Northern Siberia bears some signs of activated apoptosis (p53) and specific sensitization (IgG to benzo(a)pyrene) associated with G-allele and GG-genotype of the TP53 gene (rs1042522) (OR = 1.37–1.83, p < 0.05). These identified changes in the immune profile are comparable with effects produced by exposure to airborne benzo(a)pyrene at the dose of 86.46•10-3 µg/(kg•day) in Southern Siberia, which are associated with С-allele and СС-genotype of the same gene (OR = 1.55–2.38, p < 0.05). This confirms a hypothesis that effects of technogenic chemical factors can be modulated by specific climatic conditions in northern areas and a contribution made by genetic predisposition. Their combined effect creates a serious risk of developing impairments in an immune profile (OR = 1.37–1.83, p < 0.05; RR = 1.17; 95 % CI: 1.07–1.27) even under low-dose exposure to airborne benzo(a)pyrene.

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Polycyclic Aromatic Hydrocarbons as Ambient Air Pollutants

Sawyer,

Amabie,

Sylva

et al. 2024

The Handbook of Environmental Chemistry

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Immunotoxicity pathway and mechanism of benzo[a]pyrene on hemocytes of Chlamys farreri in vitro

Cited by 8 publications

References 80 publications

Morphological change and differential proteomics analysis of gill in Mytilus coruscus under starvation

Morphological change and differential proteomics analysis of gill in Mytilus coruscus under starvation

Polymorphism of TP53 (rs1042522) gene and peculiarities of the immune profile in children exposed to airborne benzo(a)pyrene

Polycyclic Aromatic Hydrocarbons as Ambient Air Pollutants

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