Immunotoxicity Testing: An Economical Multiple-Assay Approach

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

“…AFC/10 6 splenocyte. The in vivo delayed type hypersensitivity reaction was determined as footpad swelling in rats (Exon et al, 1986). Rats were sensitized with 100 l bovine serum albumin (BSA) (1 mg ml −1 ) in Freund's complete adjuvant (BSA-FCA) subcutaneously at the base of the tail.…”

A Sub Acute Immunotoxicity Study in G?ttingen Minipigs? with the Immunosuppressive Compounds Cyclosporin A and Dexamethasone

“…Also, in Sprague Dawley rats no effect of DEX on DTH response against KLH was observed [54] although the DTH was measured relatively late after the last DEX exposure in the latter study. In contrary, Exon et al [42,43] using different DEX treatment schedules in male Sprague Dawley rats, observed a decreased DTH response to BSA. Also in a mice study of Munson et al [36] the DTH response to SRBC was found to be reduced upon DEX exposure levels up to 0.49 mg/kg in the drinking water for 90 days.…”

“…A clear but not significant decrease in NK activity was observed after DEX treatment in minipigs. Comparable, DEX exposure of Sprague Dawley rats was associated with decreased NK cell activity in spleen cell suspensions [42,43]. Furthermore, an in vitro study by Piccolella et al [44] using human PBMC showed an inhibitory effect of DEX on NK cell activity.…”

“…In contrast, reduced spleen weights were observed in rodents after DEX exposure [36,42,43], but treatment lasted longer or other treatment routes and dose levels were used making direct comparison difficult. Thymus weights of the DEX-treated minipigs were significantly reduced in both sexes, which is in line with observations made in rodents [36,42,43]. Thus, in general the effects of CsA and DEX on body and organ weights and histopathology of lymphoid organs in the minipig are in general in agreement with those observed in other species (both rodents and non-rodents).…”

Characterization of the Reproductive Toxicity of Depleted Uranium

“…CPA suppresses T, B, and NK cell function, and induces thymic atrophy and thymocyte apoptosis (Talcott et al 1985;Exon et al 1986; O'Reilly and Exon 1986; Wang and Cai 1999). At approximately 56, 70, and 76 days of age, positive control animals were injected IP with CPA.…”