Immunotoxicology of Drugs of Abuse

Kaplan, Barbara L. F.

doi:10.1016/b978-0-12-801238-3.64180-6

Cited by 1 publication

(1 citation statement)

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“…Certainly, both the neuronal and immune systems are affected by cannabinoids. In the immune system, it is well-established that THC and CBD suppress the function of many cell types (Cabral, Rogers, & Lichtman, 2015;Kaplan, 2017). Specifically for EAE, both THC and CBD have been shown to suppress disease severity.…”

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confidence: 99%

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

Kaplan

2018

CP Toxicology

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Cannabinoid compounds refer to a group of more than 60 plant-derived compounds in Cannabis sativa, more commonly known as marijuana. Exposure to marijuana and cannabinoid compounds has been increasing due to increased societal acceptance for both recreational and possible medical use. Cannabinoid compounds suppress immune function, and while this could compromise one's ability to fight infections, immune suppression is the desired effect for therapies for autoimmune diseases. It is critical, therefore, to understand the effects and mechanisms by which cannabinoid compounds alter immune function, especially immune responses induced in autoimmune disease. Therefore, this unit will describe induction and assessment of the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS), and its potential alteration by cannabinoid compounds. The unit includes three approaches to induce EAE, two of which provide correlations to two forms of MS, and the third specifically addresses the role of autoreactive T cells in EAE. © 2018 by John Wiley & Sons, Inc.

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Section: Commentary Background Informationmentioning

confidence: 99%

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

Kaplan

2018

CP Toxicology

View full text Add to dashboard Cite

show abstract

Immunotoxicology of Drugs of Abuse

Cited by 1 publication

References 338 publications

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

Evaluation of Marijuana Compounds on Neuroimmune Endpoints in Experimental Autoimmune Encephalomyelitis

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