Immunotoxicology of Pesticides and Chemotherapies

Barnett, John B.; Brundage, Kathleen M.

doi:10.1016/b978-0-08-046884-6.00627-8

Cited by 8 publications

(7 citation statements)

References 159 publications

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“…Tebufenozide is a synthetic ecdysone agonist that interferes with the moulting process, thereby halting development (Barnett and Brundage, 2010). Tebufenozide is most effective against Lepidoptera, but less so against Coleoptera (Nakagawa, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effects of insecticides on lesser mealworm (Alphitobius diaperinus) – bioaccumulation, mortality, and growth

Meijer

Rijk

Loon³

et al. 2022

JIFF

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The lesser mealworm (LMW, Alphitobius diaperinus (Panzer); Coleoptera: Tenebrionidae) is increasingly used as a novel food and feed source. The feed materials on which this insect species is reared may contain residues of insecticides from agricultural use. The objective of this study was to determine whether selected insecticides, spiked to the substrate, could bioaccumulate in LMW and/or affect growth or survival. Insecticides were selected and spiked at concentrations equal to the legal limit in EU. Tested substances were chlorpyrifos, propoxur, imidacloprid, spinosad, tebufenozide, fipronil, pirimiphos methyl, cypermethrin, and the synergist piperonyl butoxide (PBO). Cypermethrin and PBO were also tested together. Insecticide concentrations in the spiked substrate and larvae were determined by LC-MS/MS. Concentrations in the larvae were largely below the limit of quantification, meaning that bioaccumulation did not occur. Significant reductions in total yield were observed for spinosad (present in the substrate at 1.6 mg/kg) and imidacloprid (0.12 mg/kg). Spinosad is one of few insecticides that is permitted to be used in organic agriculture, which raises questions over the safety of organic produce for insect rearing. More research on the safety of organic produce treated with this insecticide for rearing of LMW is therefore highly recommended. The reported harmful effects of insecticide residues on LMW need to be accounted for by lowering the current legal limits or reconsidering approval for use. More research is advised particularly on sublethal effects of insecticide residues on LMW on adult beetles.

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Section: Discussionmentioning

confidence: 99%

Effects of insecticides on lesser mealworm (Alphitobius diaperinus) – bioaccumulation, mortality, and growth

Meijer

Rijk

Loon³

et al. 2022

JIFF

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“…Another pre-emergent herbicide imazethapyr belongs to the imidazolinone group, a class of herbicides that inhibits acetohydroxyacid synthase in synthesizing branched-chain amino acids in plants (Tan et al, 2005). Imazethapyr is used in weed control of soybeans, alfalfa, corn, rice, and peanuts (Barnett & Brundage, 2010). The pre-emergent herbicide flumioxazin is an herbicide that blocks protoporphyrinogen oxidase (PPO) activity (Iwashita et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Efficiency of herbicides for weed control in chickpea and effect of their residues on wheat growth

Babaei

Lahooni²,

Mousavi³

et al. 2022

Agron. Colomb.

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In order to determine the best time to use and the adequate dose of four herbicides to control weeds in dryland chickpea (Cicer arietinum L.) fields, we performed the present experiment in 4 x 5 m plots. Fourteen treatments were carried out that from 1 to 9 included trifluralin. Treatments 1, 2, and 3 were with increasing doses of trifluralin (480, 720, and 960 g ai ha-1) applied 30 days before planting. Treatments 4, 5, and 6 included increasing doses of trifluralin (480, 720, and 960 g ai ha-1) applied 15 days before planting. Treatments 7, 8 and 9 consisted of increasing doses of trifluralin (480, 720, and 960 g ai ha-1) applied at the time of planting. Treatments 10, 11, and 12 included pyroxasulfone (85 g ai ha-1), flumioxazin (51 g ai ha-1) and imazethapyr (100 g ai ha-1), respectively. These last three treatments were carried out at the time of planting; treatments 13 and 14 were: weed-infested (without weed control) and weed-free (manual weeding during the entire season). Flumioxazin 66% and pyroxasulfone 57% (mean of two samples) reduced weed dry weight compared to uncontrolled treatment. The results showed that the treatments were significantly different for 100-seed weight, biological yield, and seed yield of chickpea. Weed-infested and weed-free plants had the lowest and highest grain yield. Herbicide treatments of flumioxazin, trifluralin 960 g ai ha-1, and pyroxasulfone at planting produced 55%, 44%, and 40% higher grain yield than the weed-infested plots. Also, none of the herbicide treatments reduced chickpea yield and biomass. The herbicide residues had no adverse effect on wheat growth in the next crop season.

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“…Copper-1,3,5-benzenetricarboxylate (Cu 3 (BTC) 2 (H 2 O) 3 or Cu-BTC), for example, which, in conventional form, exists as a regular bulk three-dimensional (3D) cubic structure more commonly known as HKUST-1, has been shown to possess antimicrobial activity , that can be attributed to the slow release of Cu 2+ ions that leach into solution, or to the formation of reactive oxidative species (ROS) as a consequence of free radical (e.g., hydroxyl OH • ) production , upon photoactivation. ,− It is also possible that its antimicrobial activity could arise from the physical interaction between Cu 2+ ions in the lattice with the microorganism, although this is expected to be less probable given that the metal ions in a 3D MOF are typically embedded within its internal structure, therefore requiring partial degradation of the MOF structure before the active metal sites can be exposed and hence accessed. , Additionally, a further limitation of the 3D cubic Cu-BTC MOF as an antimicrobial material is its relatively high minimum inhibitory concentration (MIC) of 40–70 mg/mL, , especially given that the use of high concentrations of soluble copper results in plant phytotoxicity, , and is hence a significant environmental concern. , Moreover, the accumulation of Cu 2+ ions from repeated application during the growing season leads to their accumulation in soil and leachate, which is detrimental to soil biota and has resulted in the development of aquatic organisms with copper-resistant strains …”

Section: Introductionmentioning

confidence: 99%

Enhanced Antimicrobial Activity and Low Phytotoxicity of Acoustically Synthesized Large Aspect Ratio Cu-BTC Metal–Organic Frameworks with Exposed Metal Sites

Marqus

Ahmed

Rezk

et al. 2021

ACS Appl. Mater. Interfaces

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Metal−organic frameworks (MOFs) have recently been shown to be effective antimicrobial agents, particularly if they comprise pathogenicidal metal ions. Nevertheless, the accessibility of these active metal sites to the pathogen, and hence the MOFs' antimicrobial activity itself, is often poor since the metal nodes are usually embedded deep within its three-dimensional (3D) structure. We show that a unique copper-based (copper(II)-benzene-1,3,5-tricarboxylate) MOF, whose quasi-two-dimensional (quasi-2D) swordlike structure facilitates exposure of the metal ions along its surface, exhibits enhanced antimicrobial properties against three representative plant pathogens: a bacterium (Pseudomonas syringae), a fungus (Fusarium solani), and a virus (Odontoglossum ringspot virus (ORSV)). Such superior antimicrobial activity results in low minimum inhibitory concentrations (MICs)half that of a commercial pesticide and an eighth of its conventional 3D cubic MOF counterpart (HKUST-1)and hence low phytotoxicity, which can be attributed to the accessibility of the surface copper sites to the pathogen, thereby facilitating their adhesion and physical contact with the MOF. Additionally, we observed that orchids treated with the quasi-2D MOF showed negligible phytotoxicity and 80% decreased viral load. This work constitutes the first study to demonstrate the antimicrobial properties of this novel MOF against bacterial, fungal, and viral plant pathogens, and the first chemical control of ORSV.

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Immunotoxicology of Pesticides and Chemotherapies

Cited by 8 publications

References 159 publications

Effects of insecticides on lesser mealworm (Alphitobius diaperinus) – bioaccumulation, mortality, and growth

Effects of insecticides on lesser mealworm (Alphitobius diaperinus) – bioaccumulation, mortality, and growth

Efficiency of herbicides for weed control in chickpea and effect of their residues on wheat growth

Enhanced Antimicrobial Activity and Low Phytotoxicity of Acoustically Synthesized Large Aspect Ratio Cu-BTC Metal–Organic Frameworks with Exposed Metal Sites

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