Impact and management of depression in psoriasis patients

Korman, Abraham M.; Hill, Denise S.; Alikhan, Ali; Feldman, Steven R.

doi:10.1517/14656566.2016.1128894

Cited by 37 publications

(46 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In previous studies, we and other authors [ 5 , 6 , 11 ] showed a strong association between psoriasis and depressed mood. However, the association of depression with the severity and duration of psoriasis remains less clear [ 15 – 16 ].…”

Section: Discussionmentioning

confidence: 57%

“…Due to this complex pathogenesis, psoriasis rarely presents in isolation, but rather co-occurs with other conditions, such as psychiatric diseases, metabolic syndrome, and alcohol and tobacco dependence [ 1 – 4 ]. Of all conditions that co-occur with psoriasis, depression is the most common, affecting up to 80% of patients with psoriasis [ 5 – 6 ]. In psoriasis, depression worsens both treatment outcomes and prognosis [ 7 ]; for example, it increases the risk of psoriatic arthritis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

Pietrzak

Grywalska

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

ObjectivePsoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.MethodsThe study included 85 men with psoriasis (mean age ± standard deviation [SD], 47 ± 14 years) and 65 men without psoriasis (mean age ± SD, 44 ± 13 years). In both groups, we measured the body mass index; blood pressure; and serum concentrations of lipids, uric acid, lipase, interleukins 6 and 18, cortisol, and 25-hydroxyvitamin D3. All participants completed the Beck Depression Inventory. Other variables analyzed included psoriasis duration, the Psoriasis Area Severity Index, and the percentage of body surface area affected by psoriatic lesions.ResultsCompared with controls, patients with psoriasis had significantly greater depression severity, higher body mass indices, and higher serum concentrations of total cholesterol and interleukins 6 and 18; moreover, they had significantly lower serum 25-hydroxyvitamin D3 concentrations. In patients with psoriasis, depression severity correlated positively with psoriasis duration, the Psoriasis Area Severity Index, the percentage of body surface area affected by psoriatic lesions, and interleukin-18 concentration. In patients with psoriasis, depression severity correlated negatively with 25-hydroxyvitamin D3 concentration, but it did not correlate significantly with the serum concentrations of interleukin 6 and cortisol.ConclusionsHigh concentrations of interleukin 18 and low concentrations of 25-hydroxyvitamin D3 may be associated with depression severity in men with psoriasis. Thus, further studies should examine whether effective anti-inflammatory treatments or vitamin D3 supplementation can improve depression outcomes in these patients.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

Pietrzak

Grywalska

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Some of these, such as cardiovascular conditions (10)(11)(12)(13), psoriatic arthritis, metabolic syndrome (10), other autoimmune conditions (14) and psychiatric conditions (anxiety and depression) (9,15) are well-documented. In addition, a number of studies have unveiled correlations (16) with liver fibrosis, sleep disorders (17), ophthalmic conditions, osteoporosis, irritable bowel syndrome, kidney disease, erectile dysfunction (18) and an increased risk of developing neoplasia (19).…”

Section: Introductionmentioning

confidence: 99%

The first nation-wide study revealing epidemiologic data and life quality aspects of psoriasis in Romania

et al. 2019

View full text Add to dashboard Cite

Psoriasis is a chronic, immune mediated, inflammatory condition, which primarily affects the patient's skin. It is known to associate a variable array of comorbidities such as cardiovascular, metabolic and psychiatric ones, with an important impact on the patients' quality of life. The purpose of this study is to provide a first image of the prevalence, comorbidities, as well as the social impact of psoriasis in Romania. We devised a questionnaire, and with the aid of general practitioners throughout the country, delivered it to patients seeking medical care in their office. The questionnaire assessed demographic criteria as well as patient-related issues. It was completed in the presence of the general practitioner, and clear written instructions for completion were included. After statistical analysis, the resulting data formed the basis of this study. The reported prevalence of psoriasis in Romania is 5.18%. Almost half of the subjects who completed the questionnaire stated they knew somebody affected by the disease, yet almost a third believed it is a contagious condition. Cardiovascular and psychiatric comorbidities, as well as negative impact on social interactions were reported by the subjects in the study. These findings indicate the clear need for better quality of life for patients in a social context and increased awareness of the disease. All these could, in turn, help decrease the rate of psoriasis complications in Romania. Materials and methodsThis is a questionnaire-based study with sample populations coming from all regions of the country, in a representative distribution. The questionnaire (available upon request) was

show abstract

“…Effective treatment of psoriasis is important as the disease reduces both physical function, psychological function, and quality of life [1]. Depending on the screening methodology, depression affects between 9 and 55% of people with psoriasis [2]. The disease is highly stigmatized owing to the visible nature of the lesions [3].…”

Section: Introductionmentioning

confidence: 99%

“…Depression prevalence in a patient population with psoriasis may be underestimated because of the lack of a universal dermatologic depression screening tool. Although multiple validated depression screening tools exist, each tool identifies different prevalence rates of depression in patients with psoriasis [2]. We performed a literature search using the PubMed and MEDLINE databases to identify articles published between 1 January 1970 and February 2017, pertaining to the inflammatory overlap between psoriasis and depression.…”

Section: Introductionmentioning

confidence: 99%

Psoriasis, Depression, and Inflammatory Overlap: A Review

et al. 2017

Self Cite

View full text Add to dashboard Cite

Psoriasis has an enormous impact on patients' lives and is frequently associated with depression. Depression in psoriasis may be attributed, at least in part, to elevated proinflammatory cytokines rather than the psychosocial impact of psoriasis itself. Biologics that target inflammatory cytokines treat the clinical manifestations of psoriasis, but may also play a role in reducing associated depression. Multiple biologics have decreased symptoms of depression during clinical trials in psoriasis; however, these studies used a variety of depression screening tools, which limits comparison. Furthermore, it is difficult to distinguish whether improved depression is the result of the direct anti-inflammatory effect of the biologic, or the indirect effect of improved psoriasis leading to better psychological status. Future studies evaluating depression in patients with psoriasis could benefit from a standardized depression screening tool to mitigate discrepancies and facilitate comparison across treatment types. Here, we highlight the inflammatory overlap between psoriasis and depression by examining the pathophysiology of depression, and reviewing psoriasis clinical studies that assessed depression as an outcome measure.

show abstract

Impact and management of depression in psoriasis patients

Cited by 37 publications

References 33 publications

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

The first nation-wide study revealing epidemiologic data and life quality aspects of psoriasis in Romania

Psoriasis, Depression, and Inflammatory Overlap: A Review

Contact Info

Product

Resources

About