Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Leotte, Jaqueline; Trombetta, Hygor; Faggion, Heloisa Z; Almeida, Bernardo Montesanti Machado de; Nogueira, Meri Bordignon; Vidal, Luíne Rosele Renaud; Raboni, Sônia Mara

doi:10.1016/j.jped.2016.07.004

Cited by 33 publications

(30 citation statements)

References 20 publications

(30 reference statements)

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“…The virus has also been associated with lower respiratory tract illnesses, including exacerbation of asthma and chronic obstructive pulmonary disease 5, 6 . HRV is globally ubiquitous and infections usually occur all year-round, although peaking in the early autumn and late spring in many temperate or subtropical countries, and in the rainy season in tropical countries 7– 9 . Despite most HRV infections being mild, they pose a considerable social and economic burden due to time lost from work or school, medical attendance and reduced performance of regular duties 10 .…”

Section: Introductionmentioning

confidence: 99%

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance

Morobe¹,

Nyiro²,

Brand³

et al. 2018

Wellcome Open Res

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Background: Human rhinovirus (HRV) is the predominant cause of upper respiratory tract infections, resulting in a significant public health burden. The virus circulates as many different types (~160), each generating strong homologous, but weak heterotypic, immunity. The influence of these features on transmission patterns of HRV in the community is understudied. Methods: Nasopharyngeal swabs were collected from patients with symptoms of acute respiratory infection (ARI) at nine out-patient facilities across a Health and Demographic Surveillance System between December 2015 and November 2016. HRV was diagnosed by real-time RT-PCR, and the VP4/VP2 genomic region of the positive samples sequenced. Phylogenetic analysis was used to determine the HRV types. Classification models and G-test statistic were used to investigate HRV type spatial distribution. Demographic characteristics and clinical features of ARI were also compared. Results: Of 5,744 NPS samples collected, HRV was detected in 1057 (18.4%), of which 817 (77.3%) were successfully sequenced. HRV species A, B and C were identified in 360 (44.1%), 67 (8.2%) and 390 (47.7%) samples, respectively. In total, 87 types were determined: 39, 10 and 38 occurred within species A, B and C, respectively. HRV types presented heterogeneous temporal patterns of persistence. Spatially, identical types occurred over a wide distance at similar times, but there was statistically significant evidence for clustering of types between health facilities in close proximity or linked by major road networks. Conclusion: This study records a high prevalence of HRV in out-patient presentations exhibiting high type diversity. Patterns of occurrence suggest frequent and independent community invasion of different types. Temporal differences of persistence between types may reflect variation in type-specific population immunity. Spatial patterns suggest either rapid spread or multiple invasions of the same type, but evidence of similar types amongst close health facilities, or along road systems, indicate type partitioning structured by local spread.

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Section: Introductionmentioning

confidence: 99%

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance

Morobe¹,

Nyiro²,

Brand³

et al. 2018

Wellcome Open Res

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“…Em pesquisa sobre o impacto e sazonalidade da infecção por Rinovírus em pacientes internados com análise de 444 amostras respiratórias, o VSR e RV também apresentaram porcentagens muito próximas de detecção sendo 37% e 36% respectivamente [8].…”

Section: Discussionunclassified

“…Em lactentes atendidos em unidades de emergência com bronquiolite viral aguda de intensidade moderada a grave, o VSR tem papel ainda mais relevante, representando o principal agente viral isolado envolvido em admissões hospitalares e nas UTI [4]. Contudo, o RV é a causa mais comum de infecções do trato respiratório superior, porém pode também comprometer a via aérea inferior e tem sido o foco dos últimos estudos na área, devido as infecções por este agente estarem associadas a exacerbações de doenças pulmonares crônicas e pneumonia fatal em pacientes nos extremos da idade ou com comorbidades pré-existentes [8] Cada vírus apresenta uma incidência diferenciada de acordo com clima, população e região. No Brasil há relatos referentes a incidência das infecções pelos vírus [4], corroborando com os achados da presente pesquisa.…”

Section: Discussionunclassified

Análise Da Incidência De Agentes Virais Causadores De Síndrome Respiratória Aguda Grave Em Pacientes Pediátricos De Um Hospital Do Paraná

Neves¹,

Schneider²,

Burger³

et al. 2018

Anais Do v Congresso Brasileiro De Eletromiografia E Cinesiologia E X Simpósio De Engenharia Biomédica

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“…Statistically, no significant difference observed between the two percentages of coinfections. Zhang and co-workers 25 reported that a high frequency of respiratory infections and coinfections was detected in children with acute respiratory symptoms. The multiplex RT-PCR assay was also able to directly detect Piv 1+3, Piv 2+4, hAdv, and hCov.…”

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confidence: 99%

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2019

IJPSR

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Background and Objectives: Acute upper respiratory tract infections are the most frequent acute illnesses worldwide. This study has been undertaken for determining the diagnostic importance of Human Rhinovirus and other associated DNA/RNA viruses including human Respiratory Syncytial virus; Human Metapneumovirus; Human parainfluenza virus 1-4; human coronavirus; Human B, C, and E Adenovirus; and Human Bocavirus in common cold disease. Further, to detect the role of some immunological parameters including complement three and rhinovirus Ag (RhV-Ag) in rhinovirus infection. Patients and methods: The samples of 84 individuals infected with common cold were collected and studied. Viral nucleic acids either DNA or RNA were extracted and amplified using real-time multiplex PCR. Results: The most common type causative agent was hRv which accounted for 56.1% followed by hRv+hRSV-hMpv, 12.19% and hRv+hAdv-hBov, 9.75% respectively. Also, the most rarely infection was hRSV-hMpv which found only in one case. On the other hand, complement three was used as a potent immuno-parameter to detect the level in a sample of 80 tested individuals infected with human rhinovirus at which it was found that there is a simple linear correlation coefficient matrix of the variables C3 and RhV-Ag. Conclusion: The study suggested that multiplex RT-PCR is a rapid, cost-effective, specific and highly sensitive method for detection of respiratory viruses including rhinovirus. Further, this study has focused a highlight on the critical roles of C3 in the pathogenesis of rhinovirus infection. Furthermore, RhV-Ag was found to be significantly correlated with the complement C3 at p<0.05 and RhV-Ag cannot be predicted using complement C3. INTRODUCTION: Human rhinoviruses (HRVs) are responsible for more than one-half of cold-like illnesses and cost billions of dollars annually in medical visits and missed days of work. HRVs are traditionally associated with upper respiratory tract infection, otitis media, and sinusitis.

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Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years

Abstract: HRV is usually detected in hospitalized children with respiratory infections and is often present in viral co-detections. Comorbidities are closely associated with HRV infections. These infections show seasonal variation, with predominance during colder seasons.

Cited by 33 publications

References 20 publications

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance

Análise Da Incidência De Agentes Virais Causadores De Síndrome Respiratória Aguda Grave Em Pacientes Pediátricos De Um Hospital Do Paraná

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