Impact du traitement antirétroviral sur le profil biologique des enfants VIH positifs suivis au Centre Hospitalier et Universitaire de Yaoundé au Cameroun

Kalla, Ginette Claude Mireille; Assoumou, Marie-Claire Okomo; Kamgaing, Nelly; Monebenimp, Francisca; Mbopi-Kéou, François-Xavier

doi:10.11604/pamj.2015.20.159.4677

Cited by 3 publications

(6 citation statements)

References 15 publications

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“…The results of the current study showed that 52.8% of patients were males. This observation of higher proportion of males over females was previously reported in similar studies 9,10 . Patients within the age group of 31–45 years old represented the highest proportion among the study population; which is also consistent with findings reported from other countries in the region 11‐15 .…”

Section: Discussionsupporting

confidence: 92%

“…This observation of higher proportion of males over females was previously reported in similar studies. 9,10 Patients within the age group of 31-45 years old represented the highest proportion among the study population; which is also consistent with findings reported from other countries in the region. [11][12][13][14][15] It is also worth noting that in this study, the majority (52.8%) of the patients were married.…”

Section: Discussionsupporting

confidence: 91%

“…Further, the results of the current study showed high levels of virological suppression rates (91.0%) are attained after 6 months of ART. These findings are comparable to those reported from Cameroon 9 . However, much lower virological suppression rates were noted in patients in studies from Senegal, Togo, and Nigeria 11,22,23 .…”

Section: Discussionsupporting

confidence: 86%

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Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Kelly

Fall

et al. 2020

Journal of Medical Virology

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Goal: The goal of this study is to determine the prevalence of therapeutic failure and the evolution of the biological factors after 6 and 12 months of anti‐retroviral treatment (ART) amongst human immunodefeciency virus (HIV) Patients receiving care through the Ambulatory Treatment Center in Nouakchott. Methods: The study presents a descriptive and retrospective analysis of 479 patients enrolled in ART between January 2015 and January 2019, with focus on treatment failures and related biomarkers. The average age of the patients studied was 37 ± 12.94 years. The majority (52.8%) were males, of whom (52.6%) were married. Results: The average body mass index (BMI) of the patients progressively increased after 6 and 12 months on ART. The average BMI increased from 20.3 ± 5.1 kg/m2, before treatment, to 21.7 ± 5.0 kg/m2 and 22.7 ± 5.4 kg/m2, after 6 and 12 months of treatment, respectively. Of the 479 patients, 97.3% were on 2 NRTIs + NNRTI. During the first 6 months of treatment, the clinical, immunological, and virological therapeutic failures were 0.6%, 34.10%, and 9%, respectively. After 6 and 12 months of ART, the TCD4, Hemoglobin, platelets, glycemia, creatinemia, and transaminase remained normal during the entire monitoring period. Conclusion: study demonstrated effective HIV treatment amongst the study patients. It showed clearance of virus and immune restoration can be attained after 6 and 12 months of ART. The number of patients who received the tests did decrease during the treatment period, which highlights the importance of adherence to patient management protocols, including clinical and biological monitoring.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Kelly

Fall

et al. 2020

Journal of Medical Virology

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“…Les résultats obtenus par Bréma [ 4 ] au Mali, signifiant un gain considérable de Lymphocytes T CD4 au cours du traitement ARV. L'étude de Ginette CMK et al a constaté une augmentation du taux moyen de toutes les variables étudiées avec une différence significative [ 13 ]. Van Dijk et collaborateurs, ont observé également dans leur série une augmentation du taux moyen des CD4 à M6 de 13% par rapport au taux moyen à l'initiation (respectivement 16,3% à M0 et 29,3% à M6) [ 14 ].…”

Section: Discussionunclassified

“…L'un des objectifs du traitement est de restaurer l'immunité. Le suivi biologique met en évidence une augmentation significative du taux de lymphocytes CD4/mm 3 dès le 6e mois après l'instauration du traitement antirétroviral [ 10 , 13 ]. La charge virale a très peu été réalisée dans notre étude 6 réalisations pour 5 patients.…”

Section: Discussionunclassified

Evolution des paramètres biochimiques et hématologiques chez les personnes vivant avec le VIH SIDA sous traitement antirétroviral au Centre Médical du Camp General Aboubacar Sangoule Lamizana (CMCGASL)

Karfo¹,

Kabré²,

Coulibaly³

et al. 2018

Pan Afr Med J

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Introductionl'objectif de ce travail était d'évaluer l'impact du traitement sur les paramètres biochimiques et hématologiques des patients VIH positifs suivis au Centre Médical du Camp Général Aboubacar Sangoulé Lamizana (CMCGASL) au Burkina Faso.Méthodesil s'agissait d'une étude rétrospective réalisée sur la période de Janvier 2010 à septembre 2015. Seuls les patients VIH positifs sous TARV ayant réalisé un bilan biologique à l'une des périodes suivantes : à l'initiation du traitement(M0), au sixième mois(M6) et au douzième mois(M12), ont été pris en compte.Résultatsle sex-ratio des patients était de 0,88 et la tranche d'âge des 45-55 ans était la plus importante. Les trithérapies incluant 2INTI + 1INNTI (74,5%), 2INTI+1 IP (14,9%) étaient les plus prescrites. La charge virale était peu demandée. Le taux des patients réguliers aux bilans biologiques avait connu une régression statistiquement significative entre M0 (70%), et M6 (13%) (p<0,05). Une augmentation significative de la valeur moyenne des lymphocytes TCD4 allant de 79,22 à M0 à 227,95 cellules/mm3 à M12 (p<0,05) était noté chez les patients sévèrement immunodéprimés. Ascension significative du taux d'hémoglobine moyen passant de 10,5 g/dl à M0 à 12,53 g/dl à M12 (p<0,05) chez les patients qui étaient anémiés. L'analyse des paramètres biochimiques n'a pu être réalisée à cause d'une insuffisance de données.Conclusionl'ascension du taux de lymphocytes TCD4 et du taux d'hémoglobine oriente sur l'efficacité du TARV et la tolérance au traitement. Il importe de rendre accessible la charge virale et d'améliorer le suivi biologique.

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Congenital Palpebral Eversion: A New Conservative Management Method (About Four Cases)

Bouba Traore

2023

JOAR

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Congenital eversion of the eyelids is a rare entity, usually presenting at birth and most frequently involving the upper eyelid. Most often, congenital eversion presents bilaterally, although unilateral cases also exist. We report four (4) cases in infants treated at our centers. We noted: 3 cases with bilateral total eversion of both upper eyelids and one case of unilateral total eversion of the left upper eyelid. We observed two cases in newborns with a clinical profile of collodion baby, which is a very rare and typical entity and two other cases in newborns with no other associated organic anomaly. The management of the four cases in our series consisted of subtarsal injections of dexamethasone, use of antibiotic-corticoid eye drops and ointments and local care, which represents a revolution in the conservative method, resulting in a total and spectacular remission after one week of treatment, with normalization of palpebral statics and spontaneous palpebral movements. In addition to conservative treatment other than our own, other authors have proposed surgical treatment using a variety of invasive procedures.

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Impact du traitement antirétroviral sur le profil biologique des enfants VIH positifs suivis au Centre Hospitalier et Universitaire de Yaoundé au Cameroun

Cited by 3 publications

References 15 publications

Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Prevalence of therapeutic failure and evolution of biological factors amongst people living with HIV enrolled in antiretroviral therapy at the Ambulatory Treatment Center in Nouakchott, Mauritania

Evolution des paramètres biochimiques et hématologiques chez les personnes vivant avec le VIH SIDA sous traitement antirétroviral au Centre Médical du Camp General Aboubacar Sangoule Lamizana (CMCGASL)

Congenital Palpebral Eversion: A New Conservative Management Method (About Four Cases)

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