Impact of 2+1 pneumococcal conjugate vaccine program in the province of Quebec, Canada

Immunization with 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) according to different schedules in infants in South Africa: a phase III trial

“…In a nested study in Finland, reductions in vaccine-type carriage, as well as a trend toward a reduction in acute otitis media, were observed with both schedules [39]. Effectiveness of PCVs administered as a 2 + 1 schedule has also been demonstrated in post-marketing studies [40][41][42]. The clinical relevance of the observed differences in antibody kinetics after 2 + 1 or 3 + 0 vaccination is however unknown as there are no clinical outcome data from randomized trials that directly compare a 2 + 1 and 3 + 0 schedule with marketed higher valent PCVs in developing countries.…”

Pneumococcal conjugate vaccines in Latin America: are PCV10 and PCV13 similar in terms of protection against serotype 19A?

“…Since, the first reports suggesting 19A decreases after transition from PCV7 to PCV10 [27], most recent preliminary data from Brazil, Colombia, and specially Chile, suggest a potential increase in 19A serotype infections. At this moment with the available evidence, PCV13 seems to offer better and longer protection than PCV10 against invasive serotype 19A infections as well as NPC reduction.…”

Pneumococcal serotype distribution: A snapshot of recent data in pediatric and adult populations around the world

“…17,20 Conjugate vaccine serotypes (i.e., serotypes included in PCV13) causing IPD among children were highly prevalent (> 60% of serotypes) in 11 reports, 6,11,12,14,16-22 including 6 of 7 European studies, 6,[16][17][18][19][20] while the highest prevalence from North American studies was 46%. 25 In contrast, conjugate vaccine serotypes causing non-IPD conditions among children were more than 50% prevalent in only 5 of 30 studies (Table 1). 31,33,40,41,44 Prevalence of serotypes uniquely covered by PPV23 was reported in a total of 33 papers.…”