Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components

Pelczyńska, Marta; Grzelak, Teresa; Sperling, Marcelina; Bogdański, Paweł; Pupek-Musialik, Danuta; Czyżewska, Krystyna

doi:10.5114/aoms.2016.58594

Cited by 22 publications

(26 citation statements)

References 36 publications

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“…There have been some reports of negative association between the DBP levels and body mass index [30]. It had thought that AIS patients were significantly underweight compared to healthy control [29]. Based on our data, the underweight in patients with AIS might be associated with the low DBP levels.…”

Section: Discussionsupporting

confidence: 62%

“…Bioavailable 25 (OH) D is believed to be free [26]. Increased DBP in the blood is thought to reduce free 25 (OH) D [27], and the association of free 25 (OH) D concentration with various diseases has been suggested [28, 29]. Together with the results of this study, vitamin D status seems to be a pivotal feature in AIS, and there is a possibility that DBP may be involved in the pathogenesis or severity of AIS.…”

Section: Discussionmentioning

confidence: 99%

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Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Makino

Seki

Kitajima

et al. 2019

BMC Musculoskelet Disord

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Background Although the pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear, there are little evidences of the pathogenesis in patients with thoracolumbar/lumbar AIS. The purpose of this study was to identify proteins or proteomes that may be causally related to the pathogenesis of AIS with structured thoracolumbar/lumbar curvature using two-dimensional fluorescence difference gel electrophoresis (2D-DIGE). Methods A total of 20 control volunteers and 61 AIS in patients with thoracolumbar/lumbar curvature were included. First, the plasma samples of each five AIS with pure thoracolumbar/lumbar curvature and control samples were subjected to 2D-DIGE analysis. Protein spots that were expressed differently by the AIS and control groups were selected and identified by nanoscale liquid chromatography–tandem mass spectrometry (nanoLC-MS/MS) analysis. To characterize the differently-expressed proteins in AIS patients, we performed functional pathway analysis using the Protein ANalysis THrough Evolutionary Relationships (PANTHER) system. Additionally, the proteins were compared between control and AIS using western blotting. Lastly, prospectively collected 15 control and 41 AIS with thoracolumbar/lumbar curvature samples were compared to the differentially expressed proteins. Results A total of 3862 ± 137 spots were detected, of which 11 spots met the criteria when compared with controls. Nine proteins were identified by nanoLC-MS/MS. Functional analysis showed the association of the proteins in AIS patients with blood coagulation using the PANTHER system. Of the proteins, vitamin D binding protein (DBP) significantly correlated with Cobb angle in thoracolumbar/lumbar curvatures. DBP expression of the prospectively collected AIS samples were significantly higher than those of controls ( P < 0.05). Conclusions This study suggests that DBP and several coagulation-related proteins may play a role in the pathogenesis of AIS. DBP appears to be a marker of severity of AIS with thoracolumbar/lumbar curvature.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Makino

Seki

Kitajima

et al. 2019

BMC Musculoskelet Disord

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“…Visceral (splanchnic) obesity has been established as an important factor in development of MeS [12, 13]. While genetic and environmental influences contribute to MeS development, the major risk factors are chronic caloric overnutrition, possibly with high fructose intake [12, 14], and physical inactivity [15, 16].…”

Section: Introductionmentioning

confidence: 99%

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Šoštarič

Jenko

Kozjek

et al. 2019

aoms

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IntroductionMetabolic syndrome and associated diseases are a global health problem. Detection of early metabolic modifications that may lead to metabolic syndrome would enable timely introduction of preventive lifestyle modifications.Material and methodsIn total 103 young, healthy adults were assessed for indicators of metabolic alterations. Anthropometric, lifestyle, genetic and biochemical parameters were assessed. Individuals who fulfilled at least one criterion for diagnosis of metabolic syndrome were assigned to the group with the higher metabolic syndrome burden (B-MeS).ResultsThe 34 young healthy individuals who were assigned to the B-MeS group had lower fat-free mass, higher body mass index, waist-to-hip ratio, fat mass, and blood pressure, more visceral fat, they were less physically active, had higher C-reactive protein values and higher catalase activity. Their phenotype was more similar to that of patients diagnosed with metabolic syndrome than the rest of the population.ConclusionsSimple anthropometric measurements, lifestyle assessment and basic biochemical measurements can be used to identify young healthy individuals with increased risk for metabolic syndrome. These assessments can be performed at periodic check-ups of the healthy population so that timely diagnosis of B-MeS can be made. As lifestyle factors have a big influence on development or improvement of the MeS, the timely diagnosis for B-MeS would enable an early opportunity for intervention for lifestyle modification in the still healthy population, saving costs and reducing disability adjusted life years.

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“…According to recent reports, it is believed that vitamin D has a beneficial effect on lowering the risk of various diseases, e.g. multiple forms of cancer, diabetes, cardiovascular diseases, metabolic syndrome, multiple sclerosis, inflammatory bowel diseases and uterine fibroids [1][2][3][4][5][6]. Vitamin D regulates cell proliferation and differentiation, inhibits angiogenesis and stimulates apoptosis [1,2,4,5].…”

mentioning

confidence: 99%

Vitamin D serum levels in women using contraception containing drospirenone – a preliminary study

Ciebiera

Włodarczyk²,

Słabuszewska-Jóźwiak

et al. 2019

aoms

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Vitamin D is a group of steroid compounds soluble in fats. Vitamin D has powerful, pleiotropic effects all over the human body. It is synthesized in human skin, but can also be found in dietary supplements and fortified foods. Vitamin D receptors (VDR) can be found in many tissues, as well as in the female reproductive tract [1,2]. According to recent reports, it is believed that vitamin D has a beneficial effect on lowering the risk of various diseases, e.g. multiple forms of cancer, diabetes, cardiovascular diseases, metabolic syndrome, multiple sclerosis, inflammatory bowel diseases and uterine fibroids [1][2][3][4][5][6]. Vitamin D regulates cell proliferation and differentiation, inhibits angiogenesis and stimulates apoptosis [1,2,4,5]. Vitamin D levels are mostly measured using serum 25-hydroxyvitamin D (25(OH)D) concentration, which is considered to be the best known marker of vitamin D obtained through both diet and body synthesis. According to Holick, the vitamin D level should be higher than 30 ng/ml [1].Ethinylestradiol (EE2) is a derivative of 17β-estradiol (E2), the major endogenous human estrogen. EE2 is used in many forms of combined oral contraception (COC) and is one of the most commonly used medications for this purpose. Ethinylestradiol is hormonally effective by activating the estrogen receptor and thus exerts its estrogenic effects [7].Drospirenone is a steroidal progestin (of the spironolactone group) used in contraception and hormonal replacement therapy. It is also an aldosterone antagonist with potassium-sparing properties. It is an agonist of the progesterone receptor and an antagonist of the mineralocorticoid and androgen receptors, and hence a progestagen, antimineralocorticoid and antiandrogen. Drospirenone does not present any estrogenic or glucocorticoid or antiglucocorticoid activity. It has a potent antigonadotropic effect at sufficient dosages as a result of progesterone receptor activation. It has been stated that drospirenone has a pharmacological profile that is closely related to that of natural progesterone [8]. Drospirenone is about ten times more potent as an antimineralocorticoid in comparison to spironolactone [8][9][10]. The drospirenone antimineralocorticoid activity promotes sodium excretion and prevents water retention [10].It is believed that contraceptives containing estrogens or estrogens combined with progestins may affect 25(OH)D serum concentrations.

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Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components

Cited by 22 publications

References 36 publications

Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Differential proteome analysis in adolescent idiopathic scoliosis patients with thoracolumbar/lumbar curvatures

Detection of metabolic syndrome burden in healthy young adults may enable timely introduction of disease prevention

Vitamin D serum levels in women using contraception containing drospirenone – a preliminary study

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