Impact of a bioactive drug coating on the biocompatibility of magnesium alloys

Liang, Quan; Ge, Shengfang; Liu, Chenyu; Jia, Dongyu; Wang, Guixue; Yin, Tieying

doi:10.1007/s10853-020-04365-4

Cited by 13 publications

(3 citation statements)

References 48 publications

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“…Following eqn (4) was used for calculation. 60 where OD T = OD of test specimen, OD NC = OD of negative control and OD PC = OD of positive control.…”

Section: Methodsmentioning

confidence: 99%

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study

Hassan,

Bilal,

Khan

et al. 2024

RSC Adv.

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“…Following eqn (4) was used for calculation. 60 where OD T = OD of test specimen, OD NC = OD of negative control and OD PC = OD of positive control.…”

Section: Methodsmentioning

confidence: 99%

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study

Hassan,

Bilal,

Khan

et al. 2024

RSC Adv.

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“…Therefore, in the LbL for Mg, it is necessary to avoid the use of biologically toxic substances. Quan et al [122] constructed the poly-β-hydroxybutyrate (PHB) coating containing vascular endothelial growth factor (VEGF) and heparin on the surface of WE Mg (Mg-4.1Y-2.8Nd-0.2Zn-0.4Zr) alloy using the LbL approach. The bioactive coating can effectively inhibit platelet adhesion and activation, thereby reducing the thrombosis.…”

Section: Biocompatible Coatingsmentioning

confidence: 99%

Advances in layer-by-layer self-assembled coatings upon biodegradable magnesium alloys

Shao

et al. 2021

Sci. China Mater.

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Magnesium (Mg) and its alloys are considered as ideal biodegradable materials due to their excellent mechanical properties and biocompatibility. In order to improve the surface properties to allow better adaptation to the surrounding tissue of the body, surface modification has played a significant role in satisfying multiple clinical requirements such as corrosion resistance, biocompatibility, and antibacterial ability. Here, layer-by-layer (LbL) self-assembly, which can be applied for biodegradable Mg alloys due to its extensive choice of usable units, holds great promise among all the surface techniques. In this review, the mechanisms of the driving force (i.e., electrostatic interaction, hydrogen bonding, charge transfer interaction and covalent bonding), cuttingedge advances in preparation methods (e.g., dipping, spraying, and spinning) and the functional properties (corrosion resistance, antibacterial activity, and biocompatibility) that could be achieved by the LbL coatings are summarized. A reasonable trend of the potential development of LbL for bio-Mg alloys is also proposed at the end of this article.

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“…The author had researched and modified the PHB film to load bioactive drugs on the surface of magnesium alloys. 18 It can effectively improve biological activity, promote cell growth, and reduce the possibility of thrombosis. The purpose of this study was to improve the adhesive strength between PHB and magnesium alloys, and increase functionality.…”

Section: Introductionmentioning

confidence: 99%

The effect of composite PHB coating on the biological properties of a magnesium based alloy

Liang

Liu

et al. 2021

J Biomater Appl

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Magnesium alloys have been widely investigated as biodegradable cardiovascular temporal implants due to their better mechanical properties and biocompatibility, but the rapid degradation limited its application. In this study, the anodic oxidation-Cu structure was used to improve the adhesive strength and stability between poly-β-hydroxybutyrate (PHB) and magnesium alloys, and the effects of anodic oxidation magnesium alloys with copper film and PHB film (MACP) on human umbilical vein endothelial cells (HUVECs), blood compatibility and antibacterial properties were investigated in this research. As the result, the MACP structure had a stable structure and better corrosion resistance, and significant antibacterial properties. The coating would not affect the original excellent biocompatibility of the magnesium alloy. It was indicated that MACP was a potential surface modification strategy for vascular stents candidate material.

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Impact of a bioactive drug coating on the biocompatibility of magnesium alloys

Cited by 13 publications

References 48 publications

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study

Advances in layer-by-layer self-assembled coatings upon biodegradable magnesium alloys

The effect of composite PHB coating on the biological properties of a magnesium based alloy

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