Impact of a cervical dysplasia and its treatment on quality of life and sexual function

Heinzler, J; Brucker, Janina; Brückner, Thomas; Dinkic, Christine; Hoffmann, Janine; Dornhöfer, Nadja; Seitz, Stephan; Sohn, Christof; Rom, Joachim; Schott, Timm Cornelius; Schott, Sarah

doi:10.1007/s00404-018-4853-y

Cited by 12 publications

(19 citation statements)

References 29 publications

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“…In non-cleared patients, our study showed a slight worsening of anxiety status and sexual function as shown by STAI-Y scores and FSFI scores before and after cervical treatment. These results are comparable to the results reported in the literature for which sexual dysfunction was seldom impacted by conization ( 53 ), but it was more related to the status of the cervical dysplasia and HPV infection rather than surgical treatment at the cervical level ( 54 ).…”

Section: Discussionsupporting

confidence: 87%

Early Mini-Invasive Treatment of Persistent Cervical Dysplasia: Clinical Outcome and Psycho-Relational Impact

Plotti

Rossini²,

Ficarola

et al. 2022

Front. Surg.

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IntroductionAfter the diagnosis of L-SIL, 77. 3% had a persistent infection and anomalous Pap Test results. Many of these patients had highlighted psychological consequences such as anxiety, hypochondria, fear of cancer, and sexual problems. Several studies suggested that the clearance of HR-HPV infection could be accelerated by cervical excisional procedures, especially in L-SIL. In consideration of the psychological implications for HPV infection and related dysplasia in patients with CIN1 at PAP-smear and HR-HPV positivity at least for 6 months, we decided to plan a prospective study where we tried to anticipate excisional cervical using a minimally invasive treatment: thin loop electrosurgical excision procedure (t-LEEP). This study aims to analyze the clearance of HR-HPV after 6 and 12 months, clinical outcomes related to t-LEEP, and the psycho-relational impact at 12 months after t-LEEP.Materials and MethodsWe enrolled patients with the diagnosis of L-SIL at PAP-smear and HR-HPV positivity with a persistent CIN 1 (at least for 6 months), confirmed by cervical biopsy. All enrolled patients underwent t-LEEP. We followed prospectively and performed for all patients the HPV DNA test at 6 (T1) and 12 months (T2) and STAI-Y and FSFI scores at T0 and T2.ResultsWe prospectively enrolled 158 patients, 22 are excluded for the established criteria. Patients with HR-HPV and CIN 1 lesions treated with t-LEEP had an overall clearance of 83.8% at T2. In subgroups analysis at T2, we had a regression: in smoker 71.8%, in contraceptive users 69.5%, in patients aged <25 years 100%, aged 25–30 years 85%, aged 30–35 years 94.4%, aged 35–40 years 92%, and aged ≥40 years 89.1%, in HPV-16 96.4%, in HPV-53 89.5%, in HPV-18 87.5%, in HPV-31 86.6%, and in coinfected 3.5%. STAI-Y and FSFI after t-LEEP (T2) were statistically significant, reducing anxiety status and improving sexual function.ConclusionBased on these results, the use of t-LEEP in patients with persistent CIN 1 and HPV-HR at least for 6 months could be useful for accelerating HPV-HR clearance, in particular, for a subpopulation patient with an increased risk of progression and/or patients with psychological and sexual consequences of carrying an HR-HPV infection.

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Section: Discussionsupporting

confidence: 87%

Early Mini-Invasive Treatment of Persistent Cervical Dysplasia: Clinical Outcome and Psycho-Relational Impact

Plotti

Rossini²,

Ficarola

et al. 2022

Front. Surg.

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“…The age of women ranged from 25 to 69 years [1,2,9,[15][16][17][18][19][20][21][22][23][24][25][26][27]; most were married [1,2,9,18,20,21,24,25,27] and lived in the United States, Germany, or Belgium [9,[15][16][17][18]20,21,23,25]. The types of cancers analyzed in women with sexual dysfunctions were breast, cervical, endometrial, ovarian, vulvar, and gynecological [1,2,9,[15][16][17][18][19][20][21][22][23][24][25][26][27]. Additionally, women with cancer were treated with surge...…”

Section: Resultsmentioning

confidence: 99%

“…The types of cancers analyzed in women with sexual dysfunctions were breast, cervical, endometrial, ovarian, vulvar, and gynecological [1,2,9,[15][16][17][18][19][20][21][22][23][24][25][26][27]. Additionally, women with cancer were treated with surgery, chemotherapy, radiotherapy, or hormonal therapy [1,2,9,[15][16][17][18][19][20][21][22][23][24][25][26][27]. The follow-up time ranged from six months to five years [16][17][18][19][20][21][22][23]25].…”

Section: Resultsmentioning

confidence: 99%

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Sexual Dysfunction in Women with Cancer: A Systematic Review of Longitudinal Studies

Guedes

Santana

et al. 2022

IJERPH

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Background: Several factors affect sexual function, including cancer development and treatment. This study summarized the risk of women with cancer of developing sexual dysfunctions. Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched the EMBASE, PubMed, LILACS, SciELO, CINAHL, Scopus, and Web of Science databases using the descriptors cancer, neoplasms, sexual dysfunction, sexual function, and women. The Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies assessed the quality of studies. Results: Sixteen studies were included in this review. Women with cancer presented sexual dysfunctions in 14 out of 16 included studies. The incidence of sexual dysfunctions ranged from 30% to 80%, while the risk of developing sexual dysfunction increased 2.7- and 3.5-fold in women with cervical and breast cancer, respectively. Conclusion: Different cancer treatments increase the risk of developing sexual dysfunction in women, especially desire, arousal, and orgasm, leading to biopsychosocial changes in the health of this population.

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“…Kanama, enfeksiyon, servikal stenoz gibi nadir görülen komplikasyonlar görülebilmektedir (4) . Reprodüktif çağdaki kadınlarda seksüel aktif dönemde yapılan LEEP kadın psikoseksüel fonksiyonlarını da etkileyebilmektedir (5)(6)(7)(8)(9)(10) .…”

Section: Introductionunclassified

Effect of Loop Electrosurgical Excision Procedure (LEEP) on Sexual Functions of Women in the Reproductive Age Group with Cervical Dysplasia

Karataşlı¹,

Budak²,

İnan³

2019

TERH

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Objective: The frequency of detecting cervical dysplasias using cervical screening programs significantly increased nowadays. Loop Electrosurgical Excision Procedure (LEEP) is one of the most common methods used for the treatment of servical dysplasias. In this study, we investigated the effect of LEEP on female sexual functions Methods: Female Sexual Function Index (FSFI) which has been reported as a reliable and valid measure also in our country was used to examine the female sexual functions in this study. Sexually active patients who were planned to be treated with LEEP were interrogated using FSFI, which includes subgroups of sexual desire, arousal, lubrication, orgasm, satisfaction and pain, and at 6. months of their follow-up, the same form was completed , and sexual function investigated. Results: In this study 35 patients treated with LEEP were investigated. The median age was 41 (range 29-52), and median parity was 2, while 60% of the patients were smokers. The mean of total FSFI scores before LEEP was 24.9±5.3, while it was 23.9±6.0 6 months after LEEP (p:0.121). In particular, the average sexual desire scores were found to be markedly lower before and after the procedure (respectively 3.3 and 3.2). Conclusion: Sexual dysfunction, especially deficient sexual desire, plays an important role in patients with cervical dysplasia treated with LEEP. However, there was no significant difference in the sexual functions of patients before and after LEEP.

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Impact of a cervical dysplasia and its treatment on quality of life and sexual function

Cited by 12 publications

References 29 publications

Early Mini-Invasive Treatment of Persistent Cervical Dysplasia: Clinical Outcome and Psycho-Relational Impact

Early Mini-Invasive Treatment of Persistent Cervical Dysplasia: Clinical Outcome and Psycho-Relational Impact

Sexual Dysfunction in Women with Cancer: A Systematic Review of Longitudinal Studies

Effect of Loop Electrosurgical Excision Procedure (LEEP) on Sexual Functions of Women in the Reproductive Age Group with Cervical Dysplasia

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