Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Thoma, Daniel S.; Sancho-Puchades, Manuel; Ettlin, Dominik A; Hämmerle, Christoph H. F.; Jung, Ronald E.

doi:10.1111/j.1600-051x.2011.01823.x

Cited by 86 publications

(82 citation statements)

References 29 publications

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“…Good epithelialization was achieved in 19 cases (63.3%), fair in seven cases (23.3%), poor in four cases (13.3%) which are in accordance with the studies of Thoma et al, K Bessho and Shobha Nataraj et al, [3,4,12]. Faster re-epithelialization achieved with better colour match to the adjacent normal tissues.…”

Section: Discussionsupporting

confidence: 89%

Versitality of the Use of Collagen Membrane in Oral Cavity

et al. 2016

JCDR

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Section: Discussionsupporting

confidence: 89%

Versitality of the Use of Collagen Membrane in Oral Cavity

et al. 2016

JCDR

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“…By modifying the macroscopic preform structure, we produce a unique particle geometry that enables us to establish microencapsulation of biological materials inside a polymeric shell of the same polymer used in the solid particles used above in the protein-binding experiments. We use collagen as the encapsulant, which may be useful for cosmetics and dental applications (58,59) and serves as a model for other potential biological materials or drugs. Like many biological materials, collagen is a globular solution lacking uniform fluid consistency, and is thus incompatible with fiber drawing and traditional microfluidics-based multiple-emulsion approaches.…”

Section: Resultsmentioning

confidence: 99%

In-fiber production of polymeric particles for biosensing and encapsulation

Kaufman

Ottman²,

Tao

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Polymeric micro-and nanoparticles are becoming a mainstay in biomedicine, medical diagnostics, and therapeutics, where they are used in implementing sensing mechanisms, as imaging contrast agents, and in drug delivery. Current approaches to the fabrication of such particles are typically finely tuned to specific monomer or polymer species, size ranges, and structures. We present a general scalable methodology for fabricating uniformly sized spherical polymeric particles from a wide range of polymers produced with complex internal architectures and continuously tunable diameters extending from the millimeter scale down to 50 nm. Controllable access to such a wide range of sizes enables broad applications in cancer treatment, immunology, and vaccines. Our approach harnesses thermally induced, predictable fluid instabilities in composite core/cladding polymer fibers drawn from a macroscopic scaled-up model called a "preform." Through a stack-and-draw process, we produce fibers containing a multiplicity of identical cylindrical cores made of the polymers of choice embedded in a polymer cladding. The instability leads to the breakup of the initially intact cores, independent of the polymer chemistry, into necklaces of spherical particles held in isolation within the cladding matrix along the entire fiber length. We demonstrate here surface functionalization of the extracted particles for biodetection through specific protein-protein interactions, volumetric encapsulation of a biomaterial in spherical polymeric shells, and the combination of both surface and volumetric functionalities in the same particle. These particles used in distinct modalities may be produced from the desired biocompatible polymer by changing only the geometry of the macroscopic preform from which the fiber is drawn.

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“…It has been used to replace the connective tissue graft from the palate, as well as for recession coverage and regeneration of keratinized mucosa around teeth and implants (4,12,20). Additionally, Mucograft® has shown promising results for use as a graft for socket seal in ridge preservation procedures (21).…”

Section: Discussionmentioning

confidence: 99%

“…A pre-clinical trial in mice used two prototype collagen matrices, namely 1 (CM1) and 2 (CM2), to study their tissue integration, biodegradation and new blood vessel formation (20). These matrices were composed of native porcine …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

et al. 2015

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Mucograft® is a resorbing porcine matrix composed of type I and type III collagen, used for soft tissue augmentation in guided tissue bony regeneration procedures. This in vitro study aimed to evaluate the biological behavior of Mucograft® in human gingival fibroblasts, as well as the ability of the matrix to induce production of extracellular matrix. Six resorbing Mucograft® matrices (MCG) were cut into 3 x 2 mm rectangles and 5 x 5 mm squares and were placed in 96-and 24-well plates, respectively. The control group (CTRL) consisted of cells plated on polystyrene without the MCG. After one, two, three and seven days, cell proliferation and viability were assessed using the Trypan exclusion method and MTT test, respectively. Type III collagen (COL 3A1) and vimentin (VIM) expression were also evaluated at 10 and 14 days, using Western blotting. Statistical analysis, using ANOVA with post hoc Bonferroni test, revealed that human gingival fibroblasts from MCG showed similar results (p>0.05) for proliferation and viability as the cells cultured on CTRL. After 14 days, a significant decrease in COL 3A1 expression (p<0.05) was observed when cultured with the MCG. VIM expression showed no significant difference at any time period (p>0.05). Although no increase in extracellular matrix secretion was observed in this in vitro study, Mucograft® presented cellular compatibility, being an option for a scaffold whenever it is required.

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Impact of a collagen matrix on early healing, aesthetics and patient morbidity in oral mucosal wounds – a randomized study in humans

Abstract: The use of CM can enhance wound healing compared with spontaneous healing during the first week. This was mainly documented by a faster re-epithelization. Colour match and wound sensitivity measurements did not reach statistical significance between CM and control sites.

Cited by 86 publications

References 29 publications

Versitality of the Use of Collagen Membrane in Oral Cavity

Versitality of the Use of Collagen Membrane in Oral Cavity

In-fiber production of polymeric particles for biosensing and encapsulation

Evaluation of the Biological Behavior of Mucograft® in Human Gingival Fibroblasts: An In Vitro Study

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