Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients

Klement, Rainer J.; Sweeney, Reinhart A.

doi:10.1007/s00066-022-01941-2

Cited by 10 publications

(4 citation statements)

References 55 publications

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“…In addition, radiotherapy is the mainstay of anti-tumor treatment, which can significantly improve the survival rate of cancer patients. Study had reported that KD preserved fat free and skeletal muscle mass and effectively improved global quality of life in breast cancer patients undergoing curative radiotherapy ( 13 ); it also partially counteracted the adverse effects of radiotherapy on body composition in head and neck cancer patients ( 42 ). Importantly, the cluster of keywords showed that immunotherapy is the new hotspot in this field recently.…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

Huang

et al. 2022

Front. Nutr.

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Increasing evidence demonstrated that the ketogenic diet (KD) played a positive effect on cancer treatment. However, no systematic review and bibliometric analysis were conducted in this field. This study aimed to explore the current status, and reveal the potential trends and hotspots to provide a reference for future research. Publications were extracted from the Web of Science Core Collection. CiteSpace (5.6.R3) software and the website of bibliometrics were used for visual analysis. A total of 500 publications with 334 articles and 166 reviews were included, with the timespan of 2012 to 2021. The United States was the most productive country. Majority of the top 10 institutions were from the United States, and Harvard University was the top-contributing institution. The most prolific author and the co-cited author was Thomas N Seyfried from Boston College. The highest cited reference was published in PLoS ONE, authored by Abdelwahab Mohammed G, with 161 citations. Glioma and breast cancer were the most common types of cancer in this field, while hepatocellular carcinoma and pancreatic cancer were the new hotspots. The anti-tumor mechanism of KD mainly focused on regulating metabolism, decanoic acid, oxidative stress, fatty acid oxidation, and cell apoptosis. Additionally, the presence of “chemotherapy” and “radiotherapy” in the keywords indicated that KD combined with anti-tumor research was a topic, while “immunotherapy” has became a recent frontiers. Notably, as a metabolic therapy, KD was deserved more attention in the treatment of hepatocellular carcinoma and pancreatic cancer, and KD combined with immunotherapy was the new hotspot and frontier. Additionally, more molecular studies and high-quality uniformly, randomized, controlled clinical trials are urgently warranted to evaluate the effect of KD in multiple cancers.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

Huang

et al. 2022

Front. Nutr.

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“…The KD has so far only been found to reduce the negative effects of treatment on body weight and body composition, with no significant effects on the patient survival. [53,54] The ACS recommends that HNC survivors adopt a diet high in vegetables, fruits, and whole grains; low in saturated fat; adequate in dietary fiber; and alcohol-free. [55] Therefore, the use of the KD should be carefully considered for patients with HNC.…”

Section: Nutritional Formulasmentioning

confidence: 99%

Rehabilitation interventions for malnutrition in head and neck cancer patients: Current state and future directions

Zhang,

2023

J Nutr Oncol

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Head and neck cancer and the approaches used to treat it can cause symptoms such as mucositis, alteration or loss of taste, dysphagia, and xerostomia, which makes the incidence of malnutrition in head and neck cancer patients higher than in the general population of cancer patients. Malnutrition in patients with head and neck cancer is associated with the occurrence of treatment-related adverse events, an increase in overall economic cost, a decline in quality of life, and a poor prognosis. Therefore, rehabilitation interventions for malnutrition are necessary throughout the course of the disease. However, the importance of rehabilitation interventions for malnutrition in patients with head and neck cancer has not been fully recognized, and the optimal methods and timing of interventions are unclear. This article provides an overview of rehabilitation interventions for malnutrition, including nutritional supplementation, exercise-based interventions, nutritional counseling and cognitive improvement, and drug therapy, and discusses their advantages and disadvantages as well as potential future directions.

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“…Thus, fatty acids become the required obligatory source of cellular energy and target the Warburg Effect in highly glycolytic tumors. (Klement & Sweeney, 2022;Voss et al, 2022;Woolf et al, 2016) The clinical trials describe KD and IFʹs role in brain cancer, non-metastasized rectal cancer, highgrade glioma (new and recurrent), head and neck squamous cell carcinoma, locally advanced and metastatic breast cancer, and ovarian and endometrial cancer. (Augustus et al, 2021;Cohen et al, 2020;Khodabakhshi et al, 2020Khodabakhshi et al, , 2021Klement, Koebrunner, et al, 2021;Klement, Weigel, et al, 2021;Klement & Sweeney, 2022;Ma et al, 2021;Porper et al, 2021;Voss et al, 2022) Results of these studies described KD as accompanying measure for cancer patients undergoing standard-of-care therapy that helps to improve the quality of life, survival with no severe side effects, and acceptable safety and tolerability in advanced cancer patients.…”

Section: Role Of Kd and If In Cancersmentioning

confidence: 99%

Role of Ketogenic Diets and Intermittent Fasting in Neurologic Diseases, Cancers and Obesity- A Comprehensive Review of Human Studies

Chelikam,

Akella,

Lakhanpal

et al. 2023

Preprint

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Non-pharmacologic options like the ketogenic diet (KD) and intermittent fasting (IF) are practical nutritional interventions with minor reported side effects like gastrointestinal symptoms, dyslipidemia, and hypomagnesemia for various medical ailments. In conjunction with IF, KD shows promise in weight loss, diabetes management, cardiovascular disorders, polycystic ovarian syndrome, cancer, and chronic neurological disorders. Based on prior research, we have examined the mechanism of action of KD and IF and their effect on neurological diseases, cancer, and obesity. We have also suggested evidence-based recommendations for the safer practice of KD and IF. Despite potential benefits, long-term adherence to KD poses challenges. Periodic KD implementation may thus benefit newly diagnosed overweight or obese patients with type 2 diabetes mellitus, aiding blood glucose and lipid management while promoting weight loss. KD is a high-fat and low-carbohydrate diet with a ratio of fat to carbohydrates and protein being 4:1 or 3:1, and thus, for peripheral tissues and the brain, fatty acids become the mandatory source of cellular energy. Ketone bodies have been used as the primary energy source during fasting. KD has been utilized as an effective treatment for refractory epilepsy since the 1920s. Evidence of the neuroprotective role of KD in diseases like epilepsy, stroke, traumatic brain injury, Alzheimer’s disease, and other neurological diseases has been noted. Since the 1960s, KD has become a popular method for obesity treatment. In addition, KD has been suggested as a potent anticancer therapy when used alone or as an adjuvant. KD may increase tumor cell sensitivity when combined with classic chemotherapy and radiotherapy. Thus, the probability that modifying the diet can help manage obesity, cancer, and chronic neurological disease without depending on pharmacological treatment and their serious side effects for a lifetime is promising and requires further investigation. KD holds promise as a potential adjunctive therapy in various neurological disorders, offering new avenues for treatment and neuroprotection. IF has shown potential in slowing the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's by promoting antioxidant defense and suppressing inflammation. KD and IF show promise in cancer therapy by targeting altered cancer cell metabolism. Additionally, KD may enhance the effects of standard treatments like chemotherapy and radiotherapy. Some of the most robust reports of keto's possible benefits have come from glioblastoma, a very aggressive brain cancer. KD has also shown strong evidence for its effectiveness in weight loss, mainly attributed to its appetite-suppressing action in ketosis. However, long-term adherence to KD can be challenging, and periodic KDs may help manage blood glucose and lipid levels in overweight or obese patients with type 2 diabetes mellitus. Likewise, IF may be more effective than regular calorie restriction for achieving weight loss goals when combined with exercise programs. More prospective human studies are warranted to evaluate both KD and IF's potential therapeutic effectiveness and safety.

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Impact of a ketogenic diet intervention during radiotherapy on body composition: V. Final results of the KETOCOMP study for head and neck cancer patients

Cited by 10 publications

References 55 publications

Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

Bibliometric and visual analysis in the field of ketogenic diet on cancer from 2012 to 2021

Rehabilitation interventions for malnutrition in head and neck cancer patients: Current state and future directions

Role of Ketogenic Diets and Intermittent Fasting in Neurologic Diseases, Cancers and Obesity- A Comprehensive Review of Human Studies

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