In order to deepen the knowledge of the seasonal variation in total cloud cover (TCC) in Xinjiang, China (XJ), a typical arid region, and to broaden the understanding of the seasonal variation in cloud type (CLT) in the region, we used TCC and CLT datasets from the latest generation of the geostationary satellite Fengyun 4A (FY-4A) from 2018 to 2022 to investigate the seasonal variation characteristics of TCC and CLT in XJ. Meanwhile, to verify the accuracy of TCC from FY-4A, ground observation (GROB) TCC datasets from 105 national meteorological stations (NMSs) in XJ and TCC datasets from ERA5 during the same period were used. In addition, the correlation between TCC from FY-4A and meteorological factors from ERA5 was also analyzed in this study. The TCC from FY-4A, GROB, and ERA5 can all well reflect the significant seasonal variation in TCC in XJ, with the highest (lowest) mean TCC and a distribution pattern of high in the southwest (northwest) and low in the northeast (southeast) in spring (fall) in XJ. Although the mean TCC from FY-4A in all four seasons was lower than that from GROB, the two were comparable in spring (44.09% and 47.32%) and summer (42.88% and 43.17%), while there was a significant difference between the two in fall (27.86% and 40.19%) and winter (30.58% and 46.93%) for 105 NMSs in XJ. The TCC from FY-4A was lower (higher) than that from GROB in spring and summer at most NMSs in northern (southern) XJ, while the TCC from FY-4A was lower than that from GROB for the vast majority of NMSs in fall and winter, especially in northern XJ. The seasonal variation in the spatial distribution of different CLTs (clear, water-type, supercooled-type, mixed-type, ice-type, cirrus-type, and overlap-type) from FY-4A exhibited diverse variation characteristics. Water-type (supercooled-water-type) had a high-frequency center of over 30% in the Tarim Basin (Kunlun Mountains) during summer. Mixed-type (ice-type and cirrus-type) had the highest frequency in winter (spring), while overlap-type had the highest frequency in summer. The correlation between TCC and water vapor conditions (total column vertically integrated water vapor, specific humidity at 250 hPa, 500 hPa, and 700 hPa) was positive in XJ.