Impact of a Nutritional Risk Index on Clinical Outcomes after Allogeneic Hematopoietic Cell Transplantation

Sagou, Ken; Ozeki, Kazutaka; Ukai, Shun; Adachi, Yoshitaka; Fukushima, Norishige; Kohno, Akio

doi:10.1016/j.bbmt.2019.07.002

Cited by 18 publications

(10 citation statements)

References 36 publications

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“…This relationship was supported by the analysis of total-TMA. NRI was a nutritional indicator widely used in oncology and we have associated a low value with outcomes of allo-HSCT in our previous study [13]. Lower concentration of serum albumin, which strongly affects NRI value, was reported to be associated with mortality of TA-TMA [24].…”

Section: Requirement Of Simple Elevation Of Ldh Regardless Ofmentioning

confidence: 84%

“…Disease risk was classified according to the refined disease risk index proposed by Armand et al [11] The hematopoietic cell transplant-comorbidity index (HCT-CI) was scored according to the report by Sorror et al [12] The nutritional risk index (NRI) was calculated at nearest time point prior conditioning regimen as previously described [13].…”

Section: Other Definitionsmentioning

confidence: 99%

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Clinical usefulness of diagnostic criteria for transplant-associated thrombotic microangiopathy

et al. 2020

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One major cause of treatment-related death is transplant-associated thrombotic microangiopathy (TA-TMA). Because of difficulties with diagnosis, many criteria for TA-TMA have been defined. Some patients clinically suspected as TA-TMA have been treated as TA-TMA regardless of TA-TMA criteria fulfillment (clinical-TMA). To examine sensitivities of TA-TMA criteria for clinical-TMA, we retrospectively evaluated 160 patients undergoing allogeneic hematopoietic stem cell transplantation by five major TA-TMA criteria and compared them with clinical-TMA. Cumulative incidences of TA-TMA and non-relapse mortality (NRM) were widely diverse between criteria. Thirty-eight patients fulfilled one or more TA-TMA criteria (total-TMA), and 12 of them fulfilled only one criterion. In patients with total-TMA, thrombocythemia, serum creatinine > 1.5 × baseline, and proteinuria were especially repeatedly observed among TA-TMA criteria. Ninety-two percent of clinical-TMA patients were classified as patients with total-TMA, and high NRM incidences were exhibited in patients with total-TMA even without clinical-TMA. Hematopoietic cell transplant-comorbidity index ≥ 3, nutritional risk index < 83.5, and grade II-IV acute graft-versus-host disease were extracted as independent risk factors for total-TMA. TA-TMA summation criteria that can cover most of clinical-TMA patients and high-risk patients of NRM were useful in clinical settings, and items of TA-TMA criteria previously described might be triggers for applying TA-TMA criteria.

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Section: Requirement Of Simple Elevation Of Ldh Regardless Ofmentioning

confidence: 84%

Section: Other Definitionsmentioning

confidence: 99%

Clinical usefulness of diagnostic criteria for transplant-associated thrombotic microangiopathy

et al. 2020

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“…The NRI is a clinical biological index that combines the strength of two nutritional indicators-albumin and weight loss. 25 Serum albumin is an important indicator of nutritional status and immunological functioning. The albumin level decreases upon the occurrence of inflammatory reactions.…”

Section: Discussionmentioning

confidence: 99%

An Analysis of Preoperative Inflammatory Indicators That Influence the Drainage Tube Retention Time in Patients with Breast Cancer Surgery

Li,

Gao,

Zhao

et al. 2024

BCTT

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Objective The study was aimed to investigate the influence factor between preoperative inflammatory indicators and drainage tube retention time in patients with breast cancer. Methods This retrospective study enrolled 121 patients with breast cancer who were undergoing surgery between October 2020 and June 2021. The enumeration data were used the Chi-square test, and the measurement data were used the t -test analysis. The univariate and multivariate logistic regression models were performed to access the risk factors for affecting drainage tube retention time in patients with breast cancer. The receiver operating characteristic curve (ROC) was performed to test the prediction effect of the model. Results Through the median extraction time of postoperative drainage tube retention time, all patients were divided into two groups: drainage tube retention time (DTRT) < 13 (d) and drainage tube retention time (DTRT) ≥ 13 (d). The results showed that type of surgery, total lymph nodes (TLN), pathological T stage, NLR were related to the drainage tube retention time (P<0.05). Moreover, the univariate and multivariate logistic regression analysis performed that Hb, type of surgery, pathological T stage, chest wall drainage tube, NRI were the independent risk predictors of affecting drainage tube retention time. Furthermore, a significant correlation existed between NRI and drainage tube retention at different times (P < 0.05). Conclusion NRI is an independent risk factor for postoperative drainage tube extraction time and can effectively predict the probability of drainage tube retention time. Thus, it can also provide personalized nursing intervention for patients with breast cancer after drainage tube retention time and the rehabilitation process.

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“…Of late, a growing number of studies report that NRI, which is established based on serum albumin levels, present body weight, and ideal body weight, represents a novel nutrition-related prognostic scoring system. Researchers have also proven that NRI shows prognostic value for primary liver cancer, allogeneic hematopoietic cell transplantation (allo-HSCT), esophageal squamous cell carcinoma, and colorectal cancer (26)(27)(28)(29). Besides, NRI is more accurate than other prognostic factors in predicting survival.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Risk Index as a Prognostic Factor Predicts the Clinical Outcomes in Patients With Stage III Gastric Cancer

et al. 2022

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ObjectiveThis study is aimed to determine the potential prognostic significance of nutritional risk index (NRI) in patients with stage III gastric cancer.MethodsA total of 202 patients with stage III gastric cancer were enrolled in this study. NRI was an index based on ideal body weight, present body weight, and serum albumin levels. All patients were divided into two groups by receiver operating characteristic curve: low NRI group (NRI<99) and high NRI group (NRI≥99). The relationship between NRI and clinicopathologic characteristics was evaluated by Chi-square test. The clinical survival outcome was analyzed by Kaplan-Meier method and compared using log-rank test. The univariate and multivariate analyses were used to detect the potential prognostic factors. A nomogram for individualized assessment of disease-free survival (DFS) and overall survival (OS). The calibration curve was used to evaluate the performance of the nomogram for predicted and the actual probability of survival time. The decision curve analysis was performed to assess the clinical utility of the nomogram by quantifying the net benefits at different threshold probabilities.ResultsThe results indicated that NRI had prognostic significance by optimal cutoff value of 99. With regard to clinicopathologic characteristics, NRI showed significant relationship with age, weight, body mass index, total protein, albumin, albumin/globulin, prealbumin, glucose, white blood cell, neutrophils, lymphocyte, hemoglobin, red blood cell, hematocrit, total lymph nodes, and human epidermal growth factor receptor 2 (P<0.05). Through the univariate and multivariate analyses, NRI, total lymph nodes, and tumor size were identified as the independent factor to predict the DFS and OS. The nomogram was used to predict the 1-, 3-, and 5-year survival probabilities, and the calibration curve showed that the prediction line matched the reference line well for 1-, 3-, and 5-year DFS and OS. Furthermore, the decision curve analysis also showed that the nomogram model yielded the best net benefit across the range of threshold probability for 1-, 3-, 5-year DFS and OS.ConclusionsNRI is described as the potential prognostic factor for patients with stage III gastric cancer and is used to predict the survival and prognosis.

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Impact of a Nutritional Risk Index on Clinical Outcomes after Allogeneic Hematopoietic Cell Transplantation

Cited by 18 publications

References 36 publications

Clinical usefulness of diagnostic criteria for transplant-associated thrombotic microangiopathy

Clinical usefulness of diagnostic criteria for transplant-associated thrombotic microangiopathy

An Analysis of Preoperative Inflammatory Indicators That Influence the Drainage Tube Retention Time in Patients with Breast Cancer Surgery

Nutritional Risk Index as a Prognostic Factor Predicts the Clinical Outcomes in Patients With Stage III Gastric Cancer

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