Impact of a pharmacist-led educational intervention on knowledge, attitude, and practice toward the rational use of antibiotics among healthcare workers in a secondary care hospital in Punjab, Pakistan

Afzal, Shairyar; Khan, Farman Ullah; Aqeel, Muhammad Tahir; Ullah, Matti; Bajwa, Mishal; Akhtar, Masoom; Majid, Muhammad

doi:10.3389/fphar.2023.1327576

Cited by 5 publications

References 56 publications

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Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review

Langdridge,

Virhia,

McMullan

et al. 2024

JAC-Antimicrobial Resistance

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Background The pressing need for better antimicrobial stewardship (AMS) is invariably reliant on educational interventions in some form. Objectives To evaluate the effectiveness of post-qualification educational interventions for AMS behaviour change among health professionals. Methods Seven databases were searched for articles published between 2013 and 2024 for post-qualification educational interventions aimed at health professionals to improve AMS. Randomised controlled trials (RCTs) and quasi-experimental designs such as non-randomised trials, controlled and non-controlled before and after studies, and qualitative studies were considered eligible. The quality of studies was assessed using Cochrane Effective Practice and Organization of Care (EPOC) criteria for RCTs and interrupted time series designs, and the Mixed Methods Appraisal Tool (MMAT) for all other studies. Data were extracted, analysed for effectiveness, and synthesised narratively. Registration: PROSPERO international prospective register of systematic reviews (PROSPERO 2023 CRD42023447115). Results Forty-six studies were included in the review, with six meeting the EPOC criteria. The remaining forty were assessed using the MMAT. The overall risk of bias for the six studies meeting the EPOC criteria was low, but risk of bias was high for studies assessed using the MMAT. Overall, there was some evidence that formal education alone was effective in this context, but only limited evidence about what type of educational intervention, for which profession, is most effective. Conclusions Our review provided an in-depth examination of post-qualification AMS interventions. We found studies were heterogeneous and quality of evidence relatively poor. High quality studies focused on establishing key components of effective educational interventions are required.

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Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review

Langdridge,

Virhia,

McMullan

et al. 2024

JAC-Antimicrobial Resistance

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Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana

Djochie,

Owusu-Donkor,

d’Almeida

et al. 2024

Preprint

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Background Prescribers must possess extensive knowledge and maintain a positive attitude towards the rational use of medicines to achieve desirable treatment outcomes and effectively prevent treatment failures, increased costs, drug toxicities, and interactions. The objective of this study was to evaluate prescribers' understanding and perception concerning the rational use of medicines in public hospitals. Additionally, the study aimed to identify the factors that influence rational prescribing practices. Methods A structured data instrument was developed to collect demographic data and evaluate participants' knowledge and perception of rational medicine use, in line with the study objectives. Chi-squared statistics and Fisher's exact test were utilized to identify factors associated with good knowledge and perception among participants. Logistic regression was then employed to assess the strength of the associations, with odd ratios reported at a significant level of 0.05. Results Out of 192 participants, 85.4% held a positive view of rational medicine use, stressing patient safety and recognizing risks like antimicrobial resistance and polypharmacy. Perception was influenced by factors such as prescriber profession, access to references, and drug bulletin updates. Additionally, 65.6% demonstrated good knowledge of rational medicine use, which was notably influenced by factors like using standard prescribing guidelines, having a functional Drug and Therapeutics Committee, prescriber profession, and the frequency of drug bulletin updates. Conclusion The study emphasizes the critical need to address knowledge gaps among healthcare professionals, especially nurses and other prescribers, to ensure the safe and effective use of medications. It highlights the positive influence of utilizing preferred prescribing references and the existence of functional Drug and Therapeutics Committees in hospitals on knowledge levels. However, the unexpected findings regarding the limited impact of frequent updates of drug bulletins require further investigation.

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Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana

Djochie,

Owusu-Donkor,

d’Almeida

et al. 2024

PLoS ONE

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Background Prescribers must possess extensive knowledge and maintain a positive attitude towards the rational use of medicines to achieve desirable treatment outcomes and effectively prevent treatment failures, increased costs, drug toxicities, and interactions. The objective of this study was to evaluate prescribers’ understanding and perception concerning the rational use of medicines in public hospitals. Additionally, the study aimed to identify the factors that influence rational prescribing practices. Methods A structured data instrument was developed to collect demographic data and evaluate participants’ knowledge and perception of rational medicine use, in line with the study objectives. Chi-squared statistics and Fisher’s exact test were utilized to identify factors associated with good knowledge and perception among participants. Logistic regression was then employed to assess the strength of the associations, with odd ratios reported at a significant level of 0.05. Results Out of 192 participants, 85.4% held a positive view of rational medicine use, stressing patient safety and recognizing risks like antimicrobial resistance and polypharmacy. Perception was influenced by factors such as prescriber profession, access to references, and drug bulletin updates. Additionally, 65.6% demonstrated good knowledge of rational medicine use, which was notably influenced by factors like using standard prescribing guidelines, having a functional Drug and Therapeutics Committee, prescriber profession, and the frequency of drug bulletin updates. Conclusion The study emphasizes the critical need to address knowledge gaps among healthcare professionals, especially nurses and other prescribers, to ensure the safe and effective use of medications. It highlights the positive influence of utilizing preferred prescribing references and the existence of functional Drug and Therapeutics Committees in hospitals on knowledge levels. However, the unexpected findings regarding the limited impact of frequent updates of drug bulletins require further investigation.

show abstract

Impact of a pharmacist-led educational intervention on knowledge, attitude, and practice toward the rational use of antibiotics among healthcare workers in a secondary care hospital in Punjab, Pakistan

Cited by 5 publications

References 56 publications

Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review

Effectiveness of work-based educational interventions for antimicrobial stewardship: a systematic review

Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana

Assessment of knowledge and perception of prescribers towards rational medicine use in the Ashanti Region of Ghana

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