Background: Venous thromboembolism (VTE), comprised of both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common complication for hospitalized patients. Clear guidance is available to practitioners in regard to risk factors for the development of VTE as well as strategies to decrease its prevalence. Despite knowing who is at risk and how to prevent VTE, practitioners provide adequate measures to only half of the patients who are eligible for VTE prophylaxis. Pharmacy practitioners within the Regina Qu'Appelle Health Region (RQHR) have been actively involved in improving VTE prophylaxis for inpatients over the past 10 years. Objective: To improve the rate of VTE prophylaxis within the RQHR, thereby improving patient safety. Methods: The strategy involved 3 phases: a preparation phase, an active intervention phase, and a maintenance and improvement phase. The preparation phase included education and participation in a national registry along with a residency project. The intervention phase consisted of a number of strategies in conjunction with 1-day VTE prophylaxis audits, and the maintenance phase consisted of ongoing educational initiatives and audits. , the percentage of patients being appropriately managed for VTE prophylaxis within the RQHR improved from 62% to 94% (P , .005). Looking specifically at our medical and surgical populations, rates increased from 47% to 90% (P , .005) and 79% to 97% (P , .005), respectively. Conclusion: The strategy was successful in improving VTE prophylaxis in the inpatient population.Hosp Pharm-2011;46(8):574-579 V enous thromboembolism (VTE), comprised of deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common complication in hospitalized medical and surgical patients, with an incidence rate of up to 40% and 60%, respectively. 1 The majority of inpatients have at least 1 risk factor for VTE, while approximately 40% have 3 or more. 2 VTE leads to significant mortality; PE is associated with a case-fatality rate of up to 12%. 3 The risk is higher in elderly patients as the 1-year mortality rate of DVT and PE reaches 21% and 40%, respectively. 4 A decade ago, the American Agency for Healthcare Research and Quality highlighted the need for inpatient VTE prophylaxis and identified it as the number one preventative strategy to improve patient safety. 5 Despite the risk and recognition over the past