Impact of acetylsalicylic acid on primary prevention of cardiovascular diseases: A meta-analysis of randomized trials

BackgroundSleep is a necessary physiological process, which is closely related to cognitive function, emotion, memory, endocrine balance, and immunity. The prevalence of sleep problems continues to rise in Chinese medical students, which has a potential influence on living and work.ObjectiveThis study aimed to observe the prevalence of sleep problems among medical students in China.MethodThe included cross-sectional studies on the prevalence of sleep problems of medical students in China were retrieved from PubMed, Embase, the Cochrane Database of Systematic Reviews, CNKI, and Wanfang database. An 11-item checklist recommended by the Agency for Healthcare Research and Quality was adopted to evaluate the methodological quality of the included studies. Software Stata 12.0, SPSS 26.0, and R were used to analyze the data. Registration: PROSPERO, CRD 42021237303.ResultThe prevalence of sleep problems among Chinese medical students was 27.38%. The subgroup analysis showed significant differences in the prevalence of sleep problems among different regions, educational backgrounds, grades, and University types. The region, latitude, and gross domestic product (GDP) were significant heterogeneous sources of sleep problems. The prevalence is positively correlated with latitude and negatively correlated with GDP per capita. Regular screening and appropriate intervention are recommended for these mental health problems.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021237303, identifier: CRD42021237303.

show abstract

“…This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols 2015 statement ( 24 , 25 ).…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Sleep Problems Among Chinese Medical Students: A Systematic Review and Meta-Analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“…e present meta-analysis was performed based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 2015 statement [15,16] and was registered on PROSPERO (CRD42020163716).…”

Section: Methodsmentioning

confidence: 99%

Xinmailong Injection for Improvement of Cardiac Function in Patients with Heart Failure: A Systematic Review and Meta‐Analysis

Sun

Qiang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Insect drugs have great potential for treating cardiovascular diseases. Xinmailong (XML) injection, a bioactive composite extracted from Periplaneta americana (a species of cockroach), was wildly used in treating heart failure in China. This meta-analysis aimed to assess the efficacy and safety of XML injection for the improvement of cardiac function in HF. Materials and Methods. Online literature search for relevant studies was performed using databases including PubMed, EMBASE, Cochrane Library, CNKI, and Wanfang. Left ventricular ejection fraction (LVEF), six-minute walk test (6MWT), and brain natriuretic peptide (BNP) were selected as target outcomes. The analysis was performed using Stata 12.0, and sources of heterogeneity were explored by subgroup analysis and metaregression. Results. 32 studies were included in this meta-analysis after meeting the inclusion/exclusion criteria. The results demonstrated that additional use of XML improved LVEF (WMD = 5.82, 95% CI: 5.52–7.13, P < 0.00001 ) and 6MWT (WMD = 51.48, 95% CI: 35.83–67.13, P < 0.00001 ) and reduced BNP (WMD = −172.84, 95% CI: −205.79 to −139.89, P < 0.00001 ). The results of subgroup analyses and metaregression suggested that XML injection has more cardiac function improvement for middle-aged HF patients than youth, and greater LVEF and 6MWT improvement were associated with higher average age. Conclusions. XML plus conventional treatment demonstrated a significant effect in reducing cardiac dysfunction in HF patients, and age is a potential factor of higher efficacy. Given the heterogeneity and bias of the included RCTs, large, prospective, rigorous trials are still needed.

show abstract

“…A meta-analysis of individual participant data from six randomised studies, published in 2009, showed that the decrease in vascular events after aspirin therapy is burdened by increased bleeding and haemorrhagic stroke rates. 7 To this topic, still a cause of controversy, the metaanalysis of Upadhaya et al, 8 published in the European Journal of Preventive Cardiology, brings further scientific evidence. This meta-analysis was designed in order to assess the risks and benefits of aspirin for primary prevention of CVD.…”

mentioning

confidence: 99%

“…To this topic, still a cause of controversy, the meta-analysis of Upadhaya et al., 8 published in the European Journal of Preventive Cardiology , brings further scientific evidence. This meta-analysis was designed in order to assess the risks and benefits of aspirin for primary prevention of CVD.…”

mentioning

confidence: 99%

Acetylsalicylic acid on primary prevention of cardiovascular diseases

Nicolini

2019

Eur J Prev Cardiolog

View full text Add to dashboard Cite

Impact of acetylsalicylic acid on primary prevention of cardiovascular diseases: A meta-analysis of randomized trials

Cited by 6 publications

References 28 publications

Prevalence of Sleep Problems Among Chinese Medical Students: A Systematic Review and Meta-Analysis

Prevalence of Sleep Problems Among Chinese Medical Students: A Systematic Review and Meta-Analysis

Xinmailong Injection for Improvement of Cardiac Function in Patients with Heart Failure: A Systematic Review and Meta‐Analysis

Acetylsalicylic acid on primary prevention of cardiovascular diseases

Contact Info

Product

Resources

About