Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women

Outhred, Tim; Das, Pritha; Felmingham, Kim L.; Bryant, Richard A.; Nathan, Pradeep J.; Malhi, Gin S; Kemp, Andrew H.

doi:10.1503/jpn.130118

Cited by 24 publications

(55 citation statements)

References 65 publications

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“…All participants were tested under placebo (saccharin) and escitalopram (20 mg; per os) conditions using a randomized, doubleblind, placebo controlled cross-over design, with a washout period of one week (or five half-lives, t 1/2 ¼ 26.7 h; Sogaard et al, 2005), as described previously (Hanson et al, 2013;Kemp et al, 2014;Outhred et al, 2014aOuthred et al, , 2014b. The present study reports fMRI findings on the emotion regulation task we employed (an eventrelated design with reappraisal of negative images).…”

Section: Experimental and Emotion Regulation Task Designmentioning

confidence: 99%

“…The present study reports fMRI findings on the emotion regulation task we employed (an eventrelated design with reappraisal of negative images). Our previous papers (Outhred et al, 2014a(Outhred et al, , 2014b reported on fMRI findings from a basic emotion processing task (a blocked design viewing negative, positive, and neutral images). The emotion regulation task results have not been previously reported.…”

Section: Experimental and Emotion Regulation Task Designmentioning

confidence: 99%

“…Single doses of antidepressants have been shown to modulate IFG and amygdala activity in healthy participants, enhancing positive emotion processing biases while attenuating negative emotion processing biases (Kemp et al, 2004a;Outhred et al, 2013Outhred et al, , 2014b. In order to further understand these changes, more specific neurocognitive processes must be dissected.…”

Section: Introductionmentioning

confidence: 99%

“…Based on our previous findings (Kemp et al, 2004a;Outhred et al, 2013;2014b) that single doses of antidepressants modulate L amygdala and R IFG activity, along with findings that reappraisal results in heightened negative connectivity between the amygdala and frontal regions (Ochsner and Gross, 2005;Banks et al, 2007), as well as behavioral findings by others indicating that antidepressants facilitate reappraisal (Ehring et al, 2010;Gotlib and Joormann, 2010;Berking and Wupperman, 2012;McRae et al, 2014), we formed the following predictions. We predicted that the functional connectivity between the L amygdala and R IFG activity would be modulated by escitalopram during reappraisal of negative emotional stimuli, such that decreased L amygdala activity would be associated with increased R IFG activity (i.e., heightened negative connectivity between these regions under escitalopram).…”

Section: Introductionmentioning

confidence: 99%

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Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study

Outhred

Das

Felmingham

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Experimental and Emotion Regulation Task Designmentioning

confidence: 99%

Section: Experimental and Emotion Regulation Task Designmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study

Outhred

Das

Felmingham

et al. 2015

Psychiatry Research: Neuroimaging

Self Cite

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“…Blocking the serotonin transporter with a selective serotonin receptor inhibitor (SSRI) raises the level of serotonin available in many structures of the brain (eg, frontal cortex, striatum, hippocampus, and raphe nucleus; Invernizzi et al, 1997). Although it usually takes some time until SSRIs reduce the clinical symptoms of depression, effects on cognition (Outhred et al, 2014;Jonassen et al, 2015) and functional neural networks (Klaassens et al, 2015) have already been described after single-dose administration. A study published by Nitsche et al (2009), eg, demonstrated that atDCSinduced enhancement of motor cortex excitability (monitored via motor-evoked potentials, MEPs) can be amplified and prolonged by a single dose of 20 mg citalopram.…”

Section: Introductionmentioning

confidence: 99%

Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults

Prehn

Stengl

Grittner

et al. 2016

Neuropsychopharmacol

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In the absence of effective therapies for dementia and its precursors, enhancing neuroplasticity by means of non-invasive brain stimulation such as anodal transcranial direct current stimulation (atDCS) might be a promising approach to counteract or delay the onset of cognitive decline, but effect sizes have been moderate so far. Previous reports indicate that increasing serotonin levels may enhance atDCS-induced neuroplasticity. However, evidence for serotonergic modulation of atDCS effects on memory is still lacking. Here, we conducted a doubleblind, randomized, sham-/placebo-controlled trial to investigate the impact of a selective serotonin reuptake inhibitor (SSRI; single dose of 20 mg citalopram) and atDCS over the right temporoparietal cortex (1 mA, 20 min) on memory formation. Twenty young and 20 older subjects completed an object-location learning task in each of the four conditions: sham+placebo, sham+SSRI, atDCS+placebo, and atDCS+SSRI. Outcome measures were performance in immediate (primary outcome) and delayed cued recall. While we found an SSRI effect, but no statistically significant effect of atDCS on immediate recall scores, young and older adults benefited most from the combined application (comparisons: atDCS+SSRI4atDCS+placebo and atDCS+SSRI4sham+placebo). Thus, our data provide evidence that atDCS improves memory formation if serotonergic neurotransmission is enhanced simultaneously. Further studies are needed to assess whether these findings extend to clinical populations with memory impairment and translate into clinically relevant improvements after long-term serotonergic enhancement and repeated stimulation.

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Ketamine administration reduces amygdalo‐hippocampal reactivity to emotional stimulation

Scheidegger

Henning

Walter

et al. 2016

Human Brain Mapping

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Increased amygdala reactivity might lead to negative bias during emotional processing that can be reversed by antidepressant drug treatment. However, little is known on how N-methyl-d-aspartate (NMDA) receptor antagonism with ketamine as a novel antidepressant drug target might modulate amygdala reactivity to emotional stimulation. Using functional magnetic resonance imaging (fMRI) and resting-state fMRI (rsfMRI), we assessed amygdalo-hippocampal reactivity at baseline and during pharmacological stimulation with ketamine (intravenous bolus of 0.12 mg/kg, followed by a continuous infusion of 0.25 mg/kg/h) in 23 healthy subjects that were presented with stimuli from the International Affective Picture System (IAPS). We found that ketamine reduced neural reactivity in the bilateral amygdalo-hippocampal complex during emotional stimulation. Reduced amygdala reactivity to negative pictures was correlated to resting-state connectivity to the pregenual anterior cingulate cortex. Interestingly, subjects experienced intensity of psychedelic alterations of consciousness during ketamine infusion predicted the reduction in neural responsivity to negative but not to positive or neutral stimuli. Our findings suggest that the pharmacological modulation of glutamate-responsive cerebral circuits, which is associated with a shift in emotional bias and a reduction of amygdalo-hippocampal reactivity to emotional stimuli, represents an early biomechanism to restore parts of the disrupted neurobehavioral homeostasis in MDD patients. Hum Brain Mapp 37:1941-1952, 2016. © 2016 Wiley Periodicals, Inc.

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Impact of acute administration of escitalopram on the processing of emotional and neutral images: a randomized crossover fMRI study of healthy women

Cited by 24 publications

References 65 publications

Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study

Facilitation of emotion regulation with a single dose of escitalopram: A randomized fMRI study

Effects of Anodal Transcranial Direct Current Stimulation and Serotonergic Enhancement on Memory Performance in Young and Older Adults

Ketamine administration reduces amygdalo‐hippocampal reactivity to emotional stimulation

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