Impact of Acute Renal Failure on the Relationship between N-Terminal pro-B-Type Natriuretic Peptide and Hemodynamic Parameters

Borggrefe, Martin; Jabor, Antonı́n; Otáhal, Michal; Waldauf, Petr; Pavlisová, Marie

doi:10.1159/000322259

Cited by 3 publications

(2 citation statements)

References 57 publications

(60 reference statements)

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“…Many studies demonstrated that the impact of RI on NPs is independent from the cardiac function. It depends not only on the RI severity but also on the duration of disease [58]. …”

Section: Limitations Of Natriuretic Peptidesmentioning

confidence: 99%

The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

Palazzuoli

Beltrami

Ruocco

et al. 2013

The Scientific World Journal

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Natriuretic peptides (NPs) are entered in current guidelines for heart failure (HF) diagnosis and management because of their high specificity and sensibility in screening patients with acute dyspnea. Due to their availability and relatively low cost, they became the first step examinations in HF patients evaluation at hospital admission together with clinical and chest radiography examination. NPs are released following any cardiac haemodynamic stress due to volume or pressure overload and should be considered as a mirror of cardiac condition helping in recognizing patients with poor outcome. Moreover, the exact role of NPs in early HF stages, in isolated diastolic dysfunction, and in general population is questioned. Several promising reports described their potential role; however, the wide cut-off definition, inclusion criteria, and intrinsic measurement biases do not actually consent to their clinical application in these settings. A multimodality strategy including both NPs and imaging studies appears to be the best strategy to define the cardiac dysfunction etiology and its severity as well as to identify patients with higher risk. In this review, we describe the current and potential role of NPs in patients with asymptomatic cardiac insufficiency, evaluating the requirement to obtain a better standardization for imaging as for laboratory criteria.

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“…Many studies demonstrated that the impact of RI on NPs is independent from the cardiac function. It depends not only on the RI severity but also on the duration of disease [58]. …”

Section: Limitations Of Natriuretic Peptidesmentioning

confidence: 99%

The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

Palazzuoli

Beltrami

Ruocco

et al. 2013

The Scientific World Journal

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“…function being dependent not only on renal insufficiency severity but also on the duration of the disease [31]. Cruz et al calculated that in the presence of this associated condition, BNP levels increased of 1/3 compared to a patient with normal renal function [32].…”

Section: Authormentioning

confidence: 99%

Natriuretic peptides and NGAL in heart failure: Does a link exist?

Palazzuoli

Beltrami

Pellegrini

et al. 2012

Clinica Chimica Acta

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In recent years there has been growing interest in the development of new diagnostic tools and particularly in laboratory tests for the identification of heart failure (HF) patients. Because of the rise in HF occurrence, it is necessary to use simple and reliable method to recognize those patients at risk before the onset of the clinical symptoms. To date HF diagnosis remains difficult: its symptoms and signs are often non specific as well as being poor sensitive indicators for HF severity. Throughout the last 10 years published literature has highlighted a boom in the use of biomarkers for HF. Both B-type and N-terminal pro-B-type natriuretic peptides have demonstrated specific role in heart failure diagnosis, as well as risk assessment. A single determination of BNP at any time during the development of chronic heart failure (CHF) provides a clinically useful tool to establish the outcome. Renal dysfunction is often associated with heart failure and predicts adverse clinical outcomes. Many studies have recently suggested the clinical use of serum neutrophil gelatinase-associated lipocalin (NGAL) levels in patients admitted to the hospital for acute HF can be used to estimate the risk of early worsening renal function. This could be potentially applied in clinical practice for early identification of renal dysfunction development in patients with HF. NGAL levels appear also to predict renal dysfunction in patients with chronic HF and preserved renal function. For all these reasons, BNP and NGAL are two emerging tools useful for diagnosis and prognosis in HF. The combination of two laboratory biomarkers could potentially identify patients with more elevated risks of both cardiac hemodynamic impairment and kidney dysfunction.

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Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease

Oyama

Boswood²,

Connolly³

et al. 2013

javma

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Impact of Acute Renal Failure on the Relationship between N-Terminal pro-B-Type Natriuretic Peptide and Hemodynamic Parameters

Cited by 3 publications

References 57 publications

The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

The Role of Natriuretic Peptides for the Diagnosis of Left Ventricular Dysfunction

Natriuretic peptides and NGAL in heart failure: Does a link exist?

Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease

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