Impact of adipose tissue on prostate cancer aggressiveness – analysis of a high-risk population

Delouya, Guila; Tiberi, David; Bhatnagar, Sahir; Campeau, Shanie; Saad, Fred; Taussky, Daniel

doi:10.1515/hmbci-2018-0049

Cited by 10 publications

(8 citation statements)

References 29 publications

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“…For extremity sarcomas, it was shown that an increase in SAT density was associated with increased overall mortality 27 . On the other hand, Delouya et al found that lower SAT density showed a trend towards more aggressive cancers, whereas VAT was a protective factor 28 …”

Section: Discussionmentioning

confidence: 99%

High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma

Hessen

Roumet

Maurer

et al. 2020

Liver International

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Background & Aims Body composition parameters have been reported to add information, which can lead to tailored treatment and prognostication for oncological patients. Data for patients with hepatocellular carcinoma (HCC) are scarce. We assessed the association between different body composition parameters and overall survival (OS) in two different newly diagnosed HCC populations. Methods The area (cm2) and density (Hounsfield Units [HU]) of skeletal muscle (SM) and adipose tissue (subcutaneous [SAT], visceral [VAT] and intermuscular [IMAT]) were measured on computed tomography (CT) scans at the level of the third lumbar vertebra (L3) in two cohorts of patients diagnosed in different HCC stages (Bern, Switzerland n = 187 and Newcastle, United Kingdom n = 216). Univariate and multivariate Cox regressions analyses were used to assess the crude and adjusted association of body composition parameters with OS. Results By univariate analysis, in both cohorts, Bern and Newcastle, high SAT density (hazard ratio [HR]: 1.35; 1.12‐1.62, P < .001 and 1.44; 1.27‐1.63, P < .001, respectively) and high VAT density (HR: 1.38; 1.1‐1.72, P = .005 and HR: 1.53; 1.3‐1.81, P < .001, respectively) correlated negatively with survival. After model adjustment for potential baseline confounders (gender, age, diabetes, cirrhosis, MELD score, BCLC stage) in a multivariate analysis, SAT density remained associated with mortality in Bern and Newcastle (Bern: HR: 1.27; 1.04‐1.57, P = .022; Newcastle: HR: 1.23; 1.03‐1.48, P = .022) and VAT remained associated with mortality in Bern (HR: 1.31; 1.05‐1.65, P = .019). Conclusions Based on two HCC cohorts, our data show that high SAT density correlates negatively with OS in HCC patients.

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Section: Discussionmentioning

confidence: 99%

High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma

Hessen

Roumet

Maurer

et al. 2020

Liver International

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“…A total of 16 cohort studies undertaking retrospective analyses [16,24,25,[33][34][35][36][37][38][39][40][41][42][43][44][45] were included in the primary analysis. During the eligibility assessment, six additional studies [46][47][48][49][50][51] were initially selected and authors contacted given the lack of specific information on the results for prostate cancer patients. Responses were not obtained and, as a result, these studies were not included in our review.…”

Section: Studies Included and Characteristicsmentioning

confidence: 99%

Associations of fat and muscle mass with overall survival in men with prostate cancer: a systematic review with meta-analysis

López

Newton

Taaffe

et al. 2021

Prostate Cancer Prostatic Dis

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Background To systematically review and analyse the associations between fat and muscle mass measures with overall survival in men with prostate cancer. Methods A systematic search was conducted in CINAHL, Cochrane Library, EMBASE, PubMed, and Web of Science databases from inception to December 2020, while abstracts from the American Society of Clinical Oncology (ASCO), Clinical Oncology Society of Australia (COSA), and the American College of Sports Medicine (ACSM) conferences were searched from 2014 to 2020. Eligible articles examined the association of body composition measures, such as fat mass (e.g., fat mass, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and VAT/SAT) and muscle mass measures, with overall survival in prostate cancer patients at any treatment stage. The primary endpoint was overall survival. Random-effect meta-analysis was conducted for studies reporting multivariable or univariable analysis assessing the associations of fat mass measures (i.e., fat mass, VAT, SAT, VAT/SAT) and muscle mass measures with overall survival. Results Sixteen cohort studies that comprised 4807 men with prostate cancer were included. Total adiposity (hazard ratio (HR) 0.98, 95% CI: 0.75–1.28, p = 0.888) and VAT (HR 1.03, 95% CI: 0.74–1.43, p = 0.873) were not significantly associated with overall survival, while higher subcutaneous adipose tissue levels were associated with higher survival (HR 0.68, 95% CI: 0.54–0.84, p = 0.001). Greater mortality risk was found in patients with localised (HR 1.91, 95% CI: 1.40–2.62, p < 0.001) and advanced disease (HR 1.43, 95% CI: 1.07–1.92, p = 0.020) presenting with low levels of muscle mass compared to those presenting with high levels. Discussion These results indicate that although overall adiposity should be cautiously interpreted in regards to survival, high muscle mass and SAT, and low VAT/SAT ratio values are associated with overall survival in men with prostate cancer.

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“…The major negative impact of increased amount of subcutaneous adipose tissue is, therefore, a rather unexpected finding. Although this is the first study reporting the negative consequences of excessive subcutaneous tissue with respect to the risk of HCC recurrence, it was previously described as a risk factor for patients with prostate cancer [34,35].…”

Section: Discussionmentioning

confidence: 99%

Impact of Body Composition on the Risk of Hepatocellular Carcinoma Recurrence After Liver Transplantation

Grąt

Pacho

Grąt

et al. 2019

JCM

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Background: Body composition parameters are reported to influence the risk of hepatocellular carcinoma (HCC) recurrence after liver resection, yet data on patients undergoing liver transplantation are scarce. The aim of this study was to evaluate the impact of the amount of abdominal adipose tissue and skeletal muscles on the risk of HCC recurrence after liver transplantation. Methods: This was a retrospective observational study performed on 77 HCC patients after liver transplantation. Subcutaneous fat area (SFA), visceral fat area, psoas muscle area and total skeletal muscle area were assessed on computed tomography on the level of L3 vertebra and divided by square meters of patient height. The primary outcome measure was five-year recurrence-free survival. Results: Recurrence-free survival in the entire cohort was 95.7%, 90.8%, and 86.5% after one, three, and five years post-transplantation, respectively. SFA was significantly associated with the risk of HCC recurrence (p = 0.013), whereas no significant effects were found for visceral fat and skeletal muscle indices. The optimal cut-off for SFA for prediction of recurrence was 71.5 cm2/m2. Patients with SFA < 71.5 cm2/m2 and ≥71.5 cm2/m2 exhibited five-year recurrence-free survival of 96.0% and 55.4%, respectively (p = 0.001). Conclusions: Excessive amount of subcutaneous adipose tissue is a risk factor for HCC recurrence after liver transplantation and may be considered in patient selection process.

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Impact of adipose tissue on prostate cancer aggressiveness – analysis of a high-risk population

Cited by 10 publications

References 29 publications

High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma

High subcutaneous adipose tissue density correlates negatively with survival in patients with hepatocellular carcinoma

Associations of fat and muscle mass with overall survival in men with prostate cancer: a systematic review with meta-analysis

Impact of Body Composition on the Risk of Hepatocellular Carcinoma Recurrence After Liver Transplantation

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