Impact of adjunctive procedures on recombinant human fibroblast growth factor‐2–mediated periodontal regeneration therapy: A retrospective study

Abstract

Background: Human fibroblast growth factor-2 (rhFGF-2) therapy has been used for periodontal tissue regeneration. However, few studies have reported their adjunctive procedures based on strategy of tissue engineering. The aim of this retrospective study is to assess the adjunctive effects of modified papilla preservation technique (mPPT) and combination with autogenous bone grafts (AG) on the rhFGF-2 therapy. Methods: Total of 44 sites underwent rhFGF-2 therapies and the evaluations in the survey periods. The primary outcome was set to the radiographic bone fill by radiographic examinations at 6 and 12 months after surgeries. We analyzed the correlation between influencing factors and the primary outcome, and differences of therapeutic effect by combination therapy with mPPT and that with AG.Results: After surgeries, probing depth (PD), clinical attachment level (CAL) and bone defects significantly improved. The improvements of radiographic bone fill were significantly positive correlated with a number of bone walls, combination with mPPT, and AG at 6 months after surgeries, and with combination with mPPT and AG at 12 months after surgeries. The significant differences of improvements of radiographic bone fill were demonstrated between combination with or without mPPT at 12 months after surgeries, and with or without AG at 6 and 12 months after surgeries. Moreover, the multiple linear regression analysis for the radiographic bone fill indicated the significant regression coefficient with conducts of mPPT. Conclusions: mPPT and AG had powerfully adjunctive effects on rhFGF-2 therapy. Further studies are needed in order to verify by randomized clinical trials.

Multi-Omics Data Integration Reveals Key Variables Contributing to Subgingival Microbiome Dysbiosis-Induced Inflammatory Response in a Hyperglycemic Microenvironment

“…Although MMP8 and MMP3 and IL-1β are important inducers of inflammation in our hyperglycemic coculture model, the multi-omics data integration model showed that FGF2, GM-CFS and IL-10 are key pro-inflammatory cytokines that play a major role in periodontitis-induced inflammatory response in a hyperglycemic microenvironment. FGF2 and IL-10 are known to enhance periodontal tissue regeneration [31] and to decrease gingival inflammation [32], respectively. Their highlighted role during periodontitis-induced inflammation may suggest that they are secreted by the coculture model to counteract pro-inflammatory cytokines and matrix metalloprotease secretion.…”

Identification of Nutritional Factors to Evaluate Periodontal Clinical Parameters in Patients with Systemic Diseases

“…who is a board-certified doctor (BD) from the Japanese Society of Periodontology. Therefore, calibration was not carried out same as in a previous study [ 35 ]. CAL was calculated based on PD, gingival recession (GE), PESA [ 6 ], and PISA, PISA/PESA was also calculated from the recorded data.…”

Association between Dietary Habit and Clinical Parameters in Patients with Chronic Periodontitis Undergoing Supportive Periodontal Therapy

“…Periodontal examinations were performed to record tooth mobility, PD, BOP [ 21 ], and plaque control records [ 22 ]. The measurements were performed as previously described [ 23 ]. The lifestyle questionnaire was administered during the patients’ most recent session of periodontal therapy (SPT2).…”