Impact of admission liver stiffness on long-term clinical outcomes in patients with acute decompensated heart failure

Omote, Kazunori; Nagai, Toshiyuki; Asakawa, Naoya; Kamiya, Kiwamu; Tokuda, Yusuke; Aikawa, Tadao; Fukushima, Arata; Noguchi, Keiji; Kato, Yoshiya; Komoriyama, Hirokazu; Nishida, Mutsumi; Kudo, Yusuke; Iwano, Hiroyuki; Yokota, Takashi; Anzai, Toshihisa

doi:10.1007/s00380-018-1318-y

Cited by 19 publications

(10 citation statements)

References 32 publications

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“…We thank Dr. Imamura for great interest in our article [1]. We and other group had demonstrated that high liver stiffness (LS) assessed by ultrasound elastography can predict elevated right atrial pressure in patients with heart failure (HF) [2,3].…”

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confidence: 99%

“…We and other group had demonstrated that high liver stiffness (LS) assessed by ultrasound elastography can predict elevated right atrial pressure in patients with heart failure (HF) [2,3]. More importantly, higher LS was also associated with increased subsequent adverse events in patients with HF [1,4]. However, its prognostic implication in patients with left ventricular assist device (LVAD) support has not been fully elucidated.…”

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confidence: 99%

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Measurements of liver stiffness in patients with left ventricular assist device support

et al. 2019

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Section: The Authors Replymentioning

confidence: 99%

Section: The Authors Replymentioning

confidence: 99%

Measurements of liver stiffness in patients with left ventricular assist device support

et al. 2019

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“…The effects of these confounding factors have been documented by many studies using TE, and their influence on different SWE techniques is still being explored in different clinical processes and patient groups [10][11][12][13]. Moreover, as pSWE is a newer technique than TE, the number of studies on the effect of congestion as a confounding factor on pSWE in pathologic processes is still limited, and none have been conducted for pulmonary arterial hypertension (PAH) to the best of our knowledge [14][15][16][17][18][19][20][21][22][23][24][25][26].…”

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confidence: 99%

Hepatic and splenic sonographic and sonoelastographic findings in pulmonary arterial hypertension

et al. 2021

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Purpose The aim of this study was to evaluate the associations of sonographic and sonoelastographic parameters with clinical cardiac parameters, as well as to assess their value in predicting survival in patients with pulmonary arterial hypertension (PAH). Methods Thirty-six patients with PAH and normal liver function were prospectively enrolled in this prospective study along with 26 healthy controls, all of whom underwent ultrasound and point shear wave elastography examinations. Additionally, the portal vein pulsatility index (PVPI), inferior vena cava collapsibility index, and clinical cardiac variables were obtained in PAH patients. The values of hepatic (LV s ) and splenic shear wave velocity (SV s ) were compared between PAH patients and controls. The relationships between all sonographic and clinical parameters in the PAH patients were analyzed. Furthermore, their prognostic value in predicting survival was investigated. Results LV s values in PAH patients (median, 1.62 m/s) were significantly higher than in controls (median, 0.99 m/s), while no significant difference was observed in SV s values. Patients with higher grades of tricuspid regurgitation (TR) had significantly different values of PVPI (P=0.010) and sonoelastographic parameters (P<0.001 for LV s and P=0.004 for SV s ) compared to those with less severe TR. Tricuspid annular plane systolic excursion values were the only investigated parameter found to be associated with survival (hazard ratio, 0.814; 95% confidence interval, 0.694 to 0.954; P=0.011). Conclusion Our results demonstrated a direct association between cardiac congestion (i.e., the severity of TR) and liver stiffness, which should be kept in mind during the assessment of fibrosis in patients with PAH.

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“…[11][12][13][14][15] Previous studies have shown that the noninvasive measurement of liver stiffness in patients without hepatic disease is reversibly associated with the severity of HF and may serve as an independent predictor for adverse clinical outcomes in this population. 12,16,17 LSM is also useful to predict right HF or the requirement of a right ventricular assist device in patients with already implanted LVAD. 18 However, a lack of knowledge exists about the association of LSM as predictor of the need for implantation of LVAD and HT.…”

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Liver stiffness and prediction of cardiac outcomes in patients with acute decompensated heart failure

Panchani

Schulz

Zyl

et al. 2021

Clinical Transplantation

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Background:In acute decompensated heart failure (ADHF), noninvasive markers that predict morbidity and mortality are limited. Liver stiffness measurement (LSM) increases with hepatic fibrosis; however, it may be falsely elevated in patients with ADHF in the absence of liver disease. We investigated whether elevated LSM predicts cardiac outcomes in ADHF. Methods:In a prospective study, we examined 52 ADHF patients without liver disease between 2016 and 2017. Patients underwent liver 2D shear wave elastography (SWE) and were followed for 12 months to assess the outcomes of left ventricular assist device (LVAD), heart transplant (HT) or death. Results:The median LSM was elevated in patients who received an LVAD or HT within 30-days compared to those who did not (median [IQR]: 55. 6 [22.5 -63.4] vs 13.8 [9.5 -40.3] kPa, p = .049). Moreover, the risk of composite outcome was highest in the 3rd tertile (> 39.8 kPa compared to 1 st and 2 nd combined, HR 2.83, 95% CI 1.20-6.67,

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Impact of admission liver stiffness on long-term clinical outcomes in patients with acute decompensated heart failure

Cited by 19 publications

References 32 publications

Measurements of liver stiffness in patients with left ventricular assist device support

Measurements of liver stiffness in patients with left ventricular assist device support

Hepatic and splenic sonographic and sonoelastographic findings in pulmonary arterial hypertension

Liver stiffness and prediction of cardiac outcomes in patients with acute decompensated heart failure

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