Impact of Adverse Childhood Experiences on Psychotic-Like Symptoms and Stress Reactivity in Daily Life in Nonclinical Young Adults

Cristóbal-Narváez, Paula; Sheinbaum, Tamara; Ballespí, Sergi; Mitjavila, Mercé; Myin‐Germeys, Inez; Kwapil, Thomas R.; Barrantes‐Vidal, Neus

doi:10.1176/appi.focus.140301

Cited by 6 publications

(2 citation statements)

References 60 publications

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“…As affective disturbances mediate the effect of daily hassles on psychotic experiences, an affective pathway to psychosis has been proposed. In line with this, ESM studies have shown that exposure to social adversity, such as childhood trauma and major life events, is associated with increased reactivity even to minor stressors in daily life, suggesting a process of behavioural sensitization. In addition, these traumatic experiences were also linked to stronger psychotic reactivity to threat anticipation in daily life in individuals at the more severe end of the psychosis continuum.…”

Section: Applications Of Esm In the Mental Health Research Fieldmentioning

confidence: 93%

Experience sampling methodology in mental health research: new insights and technical developments

et al. 2018

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In the mental health field, there is a growing awareness that the study of psychiatric symptoms in the context of everyday life, using experience sampling methodology (ESM), may provide a powerful and necessary addition to more conventional research approaches. ESM, a structured self-report diary technique, allows the investigation of experiences within, and in interaction with, the real-world context. This paper provides an overview of how zooming in on the micro-level of experience and behaviour using ESM adds new insights and additional perspectives to standard approaches. More specifically, it discusses how ESM: a) contributes to a deeper understanding of psychopathological phenomena, b) allows to capture variability over time, c) aids in identifying internal and situational determinants of variability in symptomatology, and d) enables a thorough investigation of the interaction between the person and his/her environment and of real-life social interactions. Next to improving assessment of psychopathology and its underlying mechanisms, ESM contributes to advancing and changing clinical practice by allowing a more fine-grained evaluation of treatment effects as well as by providing the opportunity for extending treatment beyond the clinical setting into real life with the development of ecological momentary interventions. Furthermore, this paper provides an overview of the technical details of setting up an ESM study in terms of design, questionnaire development and statistical approaches. Overall, although a number of considerations and challenges remain, ESM offers one of the best opportunities for personalized medicine in psychiatry, from both a research and a clinical perspective.

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Section: Applications Of Esm In the Mental Health Research Fieldmentioning

confidence: 93%

Experience sampling methodology in mental health research: new insights and technical developments

et al. 2018

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“…To date, however, only one study has reported elevated stress sensitivity in a non-clinical sample of young adults exposed to bullying [41] and, to the best of our knowledge, no study has investigated the impact of bullying victimization on individuals' affective and psychotic reactivity to stress in a sample of help-seeking youth and whether effects of bullying exposure on stress sensitivity differ across individuals at differing liability to mental health conditions. To address current knowledge gaps, a sample of adolescents and young adults receiving help from a secondary mental health service (service users), their biological siblings, and controls were recruited in the current study.…”

Section: Introductionmentioning

confidence: 99%

Bullying victimization and stress sensitivity in help-seeking youth: findings from an experience sampling study

Rauschenberg

Goedhart

et al. 2020

Eur Child Adolesc Psychiatry

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Bullying victimization confers the risk for developing various mental disorders, but studies investigating candidate mechanisms remain scarce, especially in the realm of youth mental health. Elevated stress sensitivity may constitute a mechanism linking bullying victimization and mental health problems. In the current study, we aimed to investigate whether exposure to bullying victimization amplifies stress sensitivity in youth’s daily life. The Experience Sampling Method (ESM) was used to measure stress sensitivity [i.e. the association of momentary stress with (i) negative affect and (ii) psychotic experiences] in 42 help-seeking youths (service users), 17 siblings, and 40 comparison subjects (mean age 15 years). Before ESM assessments, bullying victimization at school as well as various psychopathological domains (i.e. depression, anxiety, psychosis) were assessed. Service users exposed to high levels of overall (primary hypotheses) as well as specific types (secondary hypotheses; physical and indirect, but not verbal) of bullying victimization experienced more intense negative affect and psychotic experiences in response to stress compared to those with low exposure levels (all p < 0.05), whereas, in contrast, controls showed either less intense negative affect or no marked differences in stress sensitivity by exposure levels. In siblings, a less consistent pattern of findings was observed. Findings suggest that stress sensitivity may constitute a potential risk and resilience mechanism linking bullying victimization and youth mental health. Interventions that directly target individuals’ reactivity to stress by providing treatment components in real-life using mHealth tools may be a promising novel therapeutic approach.

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The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress‐Sensitivity

Barrantes‐Vidal,

Gizdic,

Torrecilla

et al. 2024

Stress and Health

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Stress‐sensitivity (SS) is considered a psychobiological trait possibly resulting from the interaction of genetic and environmental factors (GxE). This study examined whether the interaction of SS‐related genetic markers with interview‐based dimensions of childhood adversity predicted longitudinal trajectories of low versus high SS. Participants were nonclinically‐ascertained young adults comprising normative and elevated scores on schizotypy. SS trajectories were defined in a previous report based on three prospective assessments (23.5, 25, 28 years‐old) of both retrospective (Perceived Stress Scale; PSS) and momentary (Experience Sampling Methodology; ESM) stress ratings. A total of n = 177 and n = 165 participants with PSS and ESM stress‐sensitivity trajectories, respectively, as well as genetic data, were included in the study. GxE effects between a SS Polygenic Risk Score (PRS‐SS) and a Genetic Risk Score of the Hypothalamic Pituitary Adrenal axis (GRS‐HPA) with childhood adversity dimensions (Intrafamilial Adversity, Threat and Deprivation) on SS trajectories were examined. Threat was the most consistent predictor of persistently high SS. PRS‐SS moderated the association of Threat with high‐PSS. GRS‐HPA moderated the effects of all adversity dimensions on high‐PSS. The interaction of PRS‐SS with Deprivation and GRS‐HPA with Intrafamilial Adversity predicted trajectories of momentary social stress, but the effects were driven by those with lower genetic susceptibility. Genetic‐HPA‐axis moderates the effects of all adversity dimensions on persistent SS trajectories, as well as PRS‐SS and Threat, particularly for retrospective stress measure. The findings highlight the complex interplay between GxE factors and suggest that PSS may better capture SS trait. Including biologically‐meaningful GRS indexing SS and adversity dimensions in future studies using comprehensive stress measures would enhance our knowledge on high SS susceptibility and its relationship with diverse psychopathological outcomes.

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Impact of Adverse Childhood Experiences on Psychotic-Like Symptoms and Stress Reactivity in Daily Life in Nonclinical Young Adults

Abstract: Background

Cited by 6 publications

References 60 publications

Experience sampling methodology in mental health research: new insights and technical developments

Experience sampling methodology in mental health research: new insights and technical developments

Bullying victimization and stress sensitivity in help-seeking youth: findings from an experience sampling study

The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress‐Sensitivity

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