Impact of aerobic exercise on cognitive function in patients with schizophrenia during daily care: A meta-analysis

Xu, Yuehui; Cai, Ziyao; Fang, Chunxia; Zheng, Jie; Shan, Jianmin; Yang, Yafang

doi:10.1016/j.psychres.2022.114560

Cited by 25 publications

(7 citation statements)

References 46 publications

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“…These findings were confirmed in a recently published meta-analysis by Shimada et al 37 . In contrast, two other meta-analyses could not replicate the effect on cognition 38 or on positive symptomatology, respectively 39 .…”

Section: Evidence For the Effectiveness Of Exercise Therapy In Schizo...mentioning

confidence: 78%

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Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur Leitlinie

Falkai,

Schwaiger,

Schmitt

et al. 2023

Gesundheitswesen

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ZusammenfassungSchizophrene Psychosen sind aufgrund der Einführung von Antipsychotika vor ca. 70 Jahren in Verbindung mit der Implentierung spezifischer Psychotherapien heute deutlich besser behandelbar. Im Bereich der Negativsymptomatik und krankheitsassoziierten kognitiven Defiziten sind die aktuellen Behandlungsmöglichkeiten jedoch weiter limitiert. In den letzten 15 Jahren konnten randomisiert kontrollierte Studien (RCTs) zeigen, dass körperliches Training und insbesondere Ausdauertraining einen umfassenden ergänzenden Behandlungsansatz darstellen könnte und zu einer signifikanten Verbesserung der Positiv-, aber insbesondere auch der Negativsymptomatik und von kognitiven Defiziten zu führen vermag. In der Folge hat Sporttherapie bei schizophrenen Psychosen Eingang in die nationale Behandlungsleitlinie der Deutschen Gesellschaft für Psychiatrie, Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN), aber auch in europäische Empfehlungen, wie der European Psychiatric Association (EPA) Einzug gehalten. Im nächsten Schritt muss eine breite Implementierung in die Versorgung erfolgen, was mit der Einführung des „Living guideline“ Formats (hier erfolgt mindestens einmal jährlich eine Aktualisierung) besser als bisher möglich sein wird. Die vorliegende Arbeit bildet, basierend auf einem narrativen Review, den Prozess der Implementierung von Sporttherapie bei schizophrenen Psychosen von ihren Anfängen bis zur Verankerung in Leitlinien ab und kann analog für andere Therapieformen gelten.

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Section: Evidence For the Effectiveness Of Exercise Therapy In Schizo...mentioning

confidence: 78%

“…Diese Ergebnisse konnten in einer kürzlich veröffentlichen Metaanalyse von Shimada et al bestätigt werden [37]. Zwei weitere Metaanalysen hingegen konnten den Effekt auf Kognition [38] bzw. auf die Positivsymptomatik jedoch nicht replizieren [39].…”

Section: Einfluss Auf Die Psychische Symptomatikunclassified

Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur Leitlinie

Falkai,

Schwaiger,

Schmitt

et al. 2023

Gesundheitswesen

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“…Firth and colleagues [ 35 ] and Shimada and colleagues [ 33 ] reported that aerobic exercise causes significant improvements of medium to large size in global cognition, working memory, and attention. Firth et al [ 35 ] also found large effects on social cognition, while Xu et al [ 47 ] found no beneficial effects of aerobic exercise on working memory and attention, but only on other higher-level, ‘cool’ executive functions (reasoning and problem solving). However, those reviews neither provided a thorough analysis of the effects of physical exercise on executive functions, nor contrasted the effects on ‘cool’ and ‘hot’ executive functions that might further our understanding of the effect of physical exercise on more cognitive vs. more socio-emotional aspects of executive functioning.…”

Section: Introductionmentioning

confidence: 99%

Effects of physical exercise on executive functions of individuals with schizophrenia spectrum disorders: Protocol for a systematic review and meta-analysis

Pérez-Romero,

Campos-Jara,

Pesce

et al. 2024

PLoS ONE

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Introduction Executive functions are commonly impaired in individuals with schizophrenia spectrum disorders. Physical exercise has the potential for improving executive functions and can be easily implemented as a therapeutic method. However, there are only few systematic reviews of exercise effects in schizophrenia including cognitive outcomes, and no meta-analytical syntheses of effects on “cool” and “hot” executive functions. The purpose of this systematic review and meta-analysis will be to determine the effects of physical exercise on “cool” and “hot” executive functions of adults with schizophrenia spectrum disorders. Methods and analysis This protocol was guided by PRISMA-P guidelines. Studies will be searched using combinations of keywords and medical terms in the Web of Science, PubMed, Scopus, and EBSCO databases. Inclusion criteria will be determined as per PICOS approach. The risk of bias will be assessed using the Cochrane RoB2 tool. The certainty of evidence (per outcome) will be assessed using the GRADE method. The meta-analyses will be performed using the DerSimonian and Laird random effects model. Effect sizes (Hedges’ g) with 95% confidence intervals will be calculated for each main outcome. Conclusions The results of this review may be useful for mental health professionals to design treatment plans for adults with schizophrenia spectrum disorders, offering potential benefits related to the quality of life and cognitive abilities of this population. PROSPERO registration number CRD42023392295.

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“…To achieve symptomatic and cognitive benefits in mental disorders, aerobic exercise interventions have been proposed as a promising add-on treatment (1). Several recent metaanalyses indicate that different types of exercise can improve psychiatric symptoms (2-7), cognition (4,5) and functioning (3,5) in patients with schizophrenia, with promising findings especially for aerobic exercise interventions (6)(7)(8)(9)(10). Beneficial effects of aerobic exercise on various health outcomes in schizophrenia are considered to be driven by multiple neural adaptations that occur in response to aerobic exercise treatments (11,12).…”

Section: Introductionmentioning

confidence: 99%

Effects of aerobic exercise on hippocampal formation volume in people with schizophrenia – a systematic review and meta-analysis with original data from a randomized-controlled trial

Roell¹,

Maurus²

2023

Preprint

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Background: Aerobic exercise is a promising add-on treatment to counteract structural and functional impairments of the hippocampal formation and associated clinical outcome in schizophrenia. However, current evidence regarding exercise effects on the hippocampal formation in patients with schizophrenia is still limited and inconclusive. Therefore, we aim to assess the impact of aerobic exercise on the volume and connectivity of the hippocampal formation and explore the clinical relevance of potential exercise-induced adaptations.Methods: In this multicenter randomized-controlled clinical trial, a total of 92 patients with schizophrenia (31 female, 61 male) underwent serial MRIs and were randomly assigned to either an aerobic exercise intervention or a flexibility, strengthening and balance training as a control group. Both groups exercised three times per week for six months. Clinical assessments and structural and functional MRI scans were conducted at three consecutive timepoints. Linear mixed models, linear and logistic regressions and mediation analyses were computed to examine the effects of exercise on the volume and connectivity of the hippocampal formation and their potential clinical relevance.Results: In the aerobic exercise group, but not in the control group, volumes within the hippocampal formation increased, especially in the cornu ammonis. No effects of exercise on hippocampal formation connectivity were observed.Conclusions: The present study supports the evidence in favor of beneficial effects of aerobic exercise on hippocampal volume in patients with schizophrenia with most robust effects on CA3 and therefore underlines the potential of aerobic exercise to prevent neurodegenerative processes in this key region involved in memory processes.

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Impact of aerobic exercise on cognitive function in patients with schizophrenia during daily care: A meta-analysis

Cited by 25 publications

References 46 publications

Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur Leitlinie

Sporttherapie bei schizophrenen Psychosen: Von der Idee bis zur Leitlinie

Effects of physical exercise on executive functions of individuals with schizophrenia spectrum disorders: Protocol for a systematic review and meta-analysis

Effects of aerobic exercise on hippocampal formation volume in people with schizophrenia – a systematic review and meta-analysis with original data from a randomized-controlled trial

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