Impact of age and cardiac disease on regional left and right ventricular myocardial motion in healthy controls and patients with repaired tetralogy of fallot

Abstract

Purpose-The assessment of both left (LV) and right ventricular (RV) motion is important to understand the impact of heart disease on cardiac function. The MRI technique of tissue phase mapping (TPM) allows for the quantification of regional biventricular three-directional myocardial velocities. The goal of this study was to establish normal LV and RV velocity parameters across a wide range of pediatric to adult ages and to investigate the feasibility of TPM for detecting impaired regional biventricular function in patients with repaired tetralogy of Fallot (TOF). Methods-36 healthy controls (age=1-75 years) and 12 TOF patients (age=5-23 years) underwent cardiac MRI including TPM in short-axis locations (base, mid, apex). For ten adults, a second TPM scan was used to assess test-retest reproducibility. Data analysis included the calculation of biventricular radial, circumferential, and long-axis velocity components, quantification of systolic and diastolic peak velocities in an extended 16+10 LV+RV segment model, and assessment of inter-ventricular dyssynchrony.

Myocardial velocity, intra‐, and interventricular dyssynchrony evaluated by tissue phase mapping in pediatric heart transplant recipients

“…TPM was acquired during breath‐holding and using a prospectively ECG gated, three‐directional velocity‐encoded, and black‐blood prepared gradient echo sequence as previously described . TPM images were obtained in the short‐axis orientation at the ventricular base, mid‐ventricle, and apex.…”

“…The workflow involved manual contouring (Fig. a) of the LV and RV epi‐ and endocardium across all three slices (base, mid, apex) and time frames for all controls and patients as described previously . After correcting for eddy currents, the acquired time‐resolved velocity data was transformed from Cartesian coordinates (v y , v x , v z ) to cylindrical coordinates in radial (v r ,), circumferential (v φ ), and long‐axis (v z ) motion components adapted to the motion components of the heart (Fig.…”

“…TPM was acquired during breath-holding and using a prospectively ECG gated, three-directional velocity-encoded, and black-blood prepared gradient echo sequence as previously described. 31 TPM images were obtained in the shortaxis orientation at the ventricular base, mid-ventricle, and apex. Imaging parameters were: temporal resolution = 20.8-24.8 msec, TE/TR = 3.4-3.5/5.2-6.2 msec, in-plane resolution = (1.5-2.5 mm), 2 slice thickness = 5-8 mm, velocity sensitivity (venc) = 25 cm/s.…”

Autocalibrated cardiac tissue phase mapping with multiband imaging and k‐t acceleration

“…Velocities , , and were calculated as the phase difference of the velocity‐encoded data. Then, for both MB and SB PC data, the myocardial tissue motion of the left ventricle was analyzed using a custom MATLAB (MathWorks, Natick, MA) tool, 36 which allowed eddy current correction 37 and the manual segmentation of the myocardium. To provide a more representative view of the myocardial tissue motion, the in‐plane velocities and were transformed into a polar coordinate system as previously described 30 .…”

Cardiovascular imaging 2019 in the International Journal of Cardiovascular Imaging

“…Hu et al found that tissue tracking is feasible for assessing early ventricular dysfunction in patients post-Fontan with preserved ejection fraction [83]. Ruh et al demonstrated the feasibility of CMR tissue phase mapping to assess abnormal LV and RV motion ins tetralogy of Fallot patients [84]. Sugrue et al proposed using a time resolved MRA technique for assessing the pulmonary veins and left atrium in CHD patients [85].…”