2022
DOI: 10.1016/j.clgc.2021.12.005
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Impact of Age on Outcomes of Patients With Pure Carcinoma In Situ of the Bladder: Multi-Institutional Cohort Analysis

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Cited by 45 publications
(27 citation statements)
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“…Although this was not the aim of our study, we found an overall increased age in patients with LG and HG BC, in addition to an overall preponderance of male gender, confirmed in the logistic regression analysis as well. These data are consistent with the literature, which reports age and male gender as independent risk factors for BC, in addition to worse grade and the stage at diagnosis of elderly patients [ 5 , 37 ]. Regarding the decreased level of hemoglobin in LG and HG BC patients, compared to negative results, this finding could be related to the hematuria associated with malignancy.…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
“…Although this was not the aim of our study, we found an overall increased age in patients with LG and HG BC, in addition to an overall preponderance of male gender, confirmed in the logistic regression analysis as well. These data are consistent with the literature, which reports age and male gender as independent risk factors for BC, in addition to worse grade and the stage at diagnosis of elderly patients [ 5 , 37 ]. Regarding the decreased level of hemoglobin in LG and HG BC patients, compared to negative results, this finding could be related to the hematuria associated with malignancy.…”
Section: Discussionsupporting
confidence: 93%
“…In addition, BC ranks thirteenth in terms of deaths, with an overall mortality age-standardized ratio (ASR) of 3.2 per 100,000 in men and an ASR of 0.9 per 100,000 in women; this figure is even higher in developed countries (ASR = 4.5 per 100,000 in men and ASR = 1.1 per 100,000 in women) [ 2 ]. Despite the incidence of BC having decreased in recent years, it remains high in the elderly and in smokers [ 3 , 4 , 5 ]. BC can be divided, based on the degree of invasion, into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), with the first accounting for ~80% of total diagnosed BC [ 2 , 6 ].…”
Section: Introductionmentioning
confidence: 99%
“…A similar rate of 53% progression has been reported with 15 years of follow-up [121]. A recent study showed that older patients (age > 70 years) were more likely to present with CIS, and that in patients with pure CIS, older age was an independent predictor of poor outcome [122]. Additionally, diagnosis of CIS is complicated by significant interobserver variability of both the surgeon and the pathologist.…”
Section: Carcinoma In Situsupporting
confidence: 58%
“…In a study by Ferro et al, they evaluated the impact of age (cut-off 70 years) on predicting oncologic behavior of pure carcinoma in situ of the bladder and the response to BCG therapy in 172 patients with pure CIS. They concluded that advanced age at diagnosis appears to be associated with an increased risk of recurrence and progression of pure carcinoma in situ of the bladder after BCG therapy [ 48 ].…”
Section: Discussionmentioning
confidence: 99%