Impact of age on the diagnostic performance of pancreatic ductal diameters in detecting chronic pancreatitis

Frøkjær, Jens Brøndum; Olesen, Søren Schou; Drewes, Asbjørn Mohr; Collins, David W.; Akisik, Fatih; Swensson, Jordan

doi:10.1007/s00261-020-02522-6

Cited by 1 publication

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The 3 mm upper limit of normal for the PD was defined in an endoscopic retrograde cholangiopancreatography (ERCP) study from 1976 8 in 35 patients without pancreatic disease. In two studies, including a clinical MRCP cohort from China, the mean diameter rarely exceeded 3 mm as confirmed by us and others, [35][36][37] but the variation in asymptomatic individuals is significant and up to 10.9% of measurements are above the 3 mm limit. None of the studies provided upper reference limits.…”

Section: Comparison With Other Cohortssupporting

confidence: 58%

Definition of age-dependent reference values for the diameter of the common bile duct and pancreatic duct on MRCP: a population-based, cross-sectional cohort study

Beyer

Kasprowicz

Hannemann

et al. 2023

Gut

View full text Add to dashboard Cite

ObjectiveChanges of the pancreaticobiliary ducts herald disease. Magnetic resonance cholangiopancreatography (MRCP) allows accurate duct visualisation. Data on reliable upper reference ranges are missing.DesignCross-sectional whole body MRI data from the population-based Study of Health in Pomerania were analysed. The width of the common bile duct (CBD) and the pancreatic duct (PD) was determined. We aimed to describe the distribution of physiological duct diameters on MRCP in a population of healthy subjects and to identify factors influencing duct size.ResultsAfter excluding pre-existing pancreaticobiliary conditions, CBD and PD diameters from 938 and 774 healthy individuals, respectively, showed a significant increase with age (p<0.0001) and exceeded the conventional upper reference limit of normal in 10.9% and 18.2%, respectively. Age-dependent upper reference limits of duct diameters were delineated with non-parametric quantile regression, defined as 95th percentile: for CBD up to 8 mm in subjects <65 years and up to 11 mm in subjects ≥65 years. For the PD reference diameters were up to 3 mm in subjects <65 years and up to 4 mm in subjects ≥65 years.ConclusionsThis is the first population-based study delineating age-adjusted upper reference limits of CBD and PD on MRCP. We showed that up to 18.2% of healthy volunteers would have needed diagnostic workup, if the conventional reference values were used. The utilisation of the adapted reference levels may help to avoid unnecessary investigations and thus to reduce healthcare expenditure and test-related adverse events.

show abstract

Section: Comparison With Other Cohortssupporting

confidence: 58%