Impact of air pollution on ischemic heart disease: Evidence, mechanisms, clinical perspectives

Montone, Rocco Antonio; Rinaldi, Riccardo; Bonanni, Alice; Severino, Anna; Pedicino, Daniela; Crea, Filippo; Liuzzo, Giovanna

doi:10.1016/j.atherosclerosis.2023.01.013

Cited by 40 publications

(11 citation statements)

References 110 publications

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“…The most consistent findings are for short-and long-term exposure to ambient air pollution, specifically particulate matter <2.5 μm. [30][31][32] Other air pollutants such as carbon monoxide, ozone, and particulate matter 10 have also been linked to hospitalization or mortality in patients with heart failure. 32 Although this area remains understudied compared with the physical environment, a growing number of longitudinal studies have examined aspects of the neighborhood social environment, including socioeconomic position, social cohesion (mutual trust and willingness to help one another), and social hazards (eg, crime) to cardiovascular outcomes.…”

Section: Neighborhood Physical and Social Environments And Cvhmentioning

confidence: 99%

“…The most consistent findings are for short- and long-term exposure to ambient air pollution, specifically particulate matter <2.5 μm. 30–32 Other air pollutants such as carbon monoxide, ozone, and particulate matter 10 have also been linked to hospitalization or mortality in patients with heart failure. 32…”

Section: Observational Studies Examining the Contribution Of Neighbor...mentioning

confidence: 99%

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Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association

Kershaw,

Magnani,

Diez Roux

et al. 2024

Circ: Cardiovascular Quality and Outcomes

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The neighborhoods where individuals reside shape environmental exposures, access to resources, and opportunities. The inequitable distribution of resources and opportunities across neighborhoods perpetuates and exacerbates cardiovascular health inequities. Thus, interventions that address the neighborhood environment could reduce the inequitable burden of cardiovascular disease in disenfranchised populations. The objective of this scientific statement is to provide a roadmap illustrating how current knowledge regarding the effects of neighborhoods on cardiovascular disease can be used to develop and implement effective interventions to improve cardiovascular health at the population, health system, community, and individual levels. PubMed/Medline, CINAHL, Cochrane Library reviews, and ClinicalTrials.gov were used to identify observational studies and interventions examining or targeting neighborhood conditions in relation to cardiovascular health. The scientific statement summarizes how neighborhoods have been incorporated into the actions of health care systems, interventions in community settings, and policies and interventions that involve modifying the neighborhood environment. This scientific statement presents promising findings that can be expanded and implemented more broadly and identifies methodological challenges in designing studies to evaluate important neighborhood-related policies and interventions. Last, this scientific statement offers recommendations for areas that merit further research to promote a deeper understanding of the contributions of neighborhoods to cardiovascular health and health inequities and to stimulate the development of more effective interventions.

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Section: Neighborhood Physical and Social Environments And Cvhmentioning

confidence: 99%

Section: Observational Studies Examining the Contribution Of Neighbor...mentioning

confidence: 99%

Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association

Kershaw,

Magnani,

Diez Roux

et al. 2024

Circ: Cardiovascular Quality and Outcomes

View full text Add to dashboard Cite

show abstract

“…Since the year 2000, CVD has experienced the most signi cant increase in mortality, reaching nearly 9 million deaths in 2019, an increase of over 2 million deaths (39). Various studies have examined the effects of exposure to air pollution on the occurrence of CVD (45)(46)(47). Furthermore, the systematic review conducted by Yamamoto et al (2014), which focused on air pollution as a risk factor for CVD, provided evidence indicating that air pollution is a risk factor for CVD in South Asia (48).…”

Section: Cluster #3: Cardiovascular Disease (Cvd)mentioning

confidence: 99%

The Role of Environmental Health in the Prevention and Control of Environment-Related Diseases Worldwide

Ravanipour,

Hamidi

2024

Preprint

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Environmental factors are crucial in the global health landscape and the burden of diseases. Scientometrics is a quantitative method used to better analyze research status and trends in a specific subject area. This study aims to analyse the role of environmental health in preventing and controlling diseases. A total of 50,274 documents were retrieved. The US and Harvard University were the most prolific and influential countries and organizations. The top three journals were PLOSONE, International Journal of Environmental Research and Public Health, and Environmental Health Perspectives. The highest interest is in burden of disease and air pollution, mainly particulate matter and PM2.5. The main focus are on air pollution, cardiovascular diseases, coronavirus disease, inflammatory bowel disease, multiple sclerosis, cognitive decline, and COVID-19 lockdown. In the early years, studies predominantly centered on exposures, but investigating the relationship between these factors and medical science and health has become a significant area of interest in recent years. Air pollutants and burden of disease are topics of interest recognized as global environmental challenges.

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“…Later, Camilli et al demonstrated that long-term exposure to pollutants—and to particulate matter 2.5 in particular—predicts a positive response to the ACh test and MINOCA as clinical presentation [ 62 ]. A putative pathogenetic role of low-grade inflammation and endothelial dysfunction, triggered by pollutants, has been postulated [ 63 , 64 ].…”

Section: Pathophysiologymentioning

confidence: 99%

Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders

Gurgoglione,

Vignali,

Montone

et al. 2024

Life

Self Cite

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Coronary vasomotor disorders (CVD) are characterized by transient hypercontraction of coronary vascular smooth muscle cells, leading to hypercontraction of epicardial and/or microvascular coronary circulation. CVDs play a relevant role in the pathogenesis of ischemia, angina and myocardial infarction with non-obstructive coronary arteries. Invasive provocative testing with intracoronary Acetylcholine (ACh) administration is the gold standard tool for addressing CVD, providing relevant therapeutic and prognostic implications. However, safety concerns preclude the widespread incorporation of the ACh test into clinical practice. The purpose of this review is to shed light on the pathophysiology underlying CVD and on the clinical role of the ACh test, focusing on safety profile and prognostic implications. We will also discuss contemporary evidence on the management of CVD and the role of the ACh test in driving a personalized approach of patients with CVD.

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Impact of air pollution on ischemic heart disease: Evidence, mechanisms, clinical perspectives

Cited by 40 publications

References 110 publications

Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association

Neighborhoods and Cardiovascular Health: A Scientific Statement From the American Heart Association

The Role of Environmental Health in the Prevention and Control of Environment-Related Diseases Worldwide

Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders

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