Impact of AKAP6 Polymorphisms on Glioma Susceptibility and Prognosis

Abstract

Purpose Glioma is the most common primary malignant brain tumor with high mortality and poor prognosis. Our aim was to clarify the correlation between AKAP6 gene polymorphisms and glioma susceptibility and prognosis in Chinese Han population. Methods Five single-nucleotide polymorphisms (SNPs) of AKAP6 were genotyped by Agena MassARRAY in 575 glioma patients and 500 healthy controls. Logistic regression model was utilized to calculate odds ratios (OR) and 95% confidence intervals (CI). The associations between polymorphisms and survival were assessed using the log-rank test, Kaplan-Meier analysis and Cox regression model. Results We found that rs2239647 polymorphism was strongly associated with an increased risk of glioma (OR = 1.90, p = 0.007) and a worse prognosis for glioma, especially in high-grade glioma (HR = 1.67, p = 0.034). Stratified analysis showed that rs2239647 increased the risk of glioma in female (OR = 1.62, p = 0.016). Whereas, rs4261436 (HR = 0.70, p = 0.045) and rs17522122 (HR = 0.75, p = 0.016) were associated with better prognosis of astrocytoma. In addition, we also found that surgical methods and chemotherapy are critical factors for the prognosis of glioma patients. Conclusions This study firstly provided evidence for the impact of AKAP6 polymorphisms on susceptibility and prognosis of glioma, suggesting AKAP6 variants might have potential roles in the etiology of glioma.

Spin-Allowed Transitions Control the Formation of Triplet Excited States in Orthogonal Donor-Acceptor Dyads

“…Although F T of non-D-A type BODIPYs is close to 0 as discussed above, we can enhance the triplet formation of BODIPYs by including heavy atoms such as iodine (e.g., diiodo-BODIPYs [66][67][68] ) as well as that of other p-conjugated molecules. 9 Perylene, on the other hand, is known for the lack of triplet formation itself (Figure S11), and more importantly the lack of a heavy atom effect on the formation of triplets; F T of bromoperylene is still 0.01.…”