Impact of albumin on drug delivery — New applications on the horizon

Elsadek, Bakheet; Kratz, Felix

doi:10.1016/j.jconrel.2011.09.069

Cited by 734 publications

(588 citation statements)

References 120 publications

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“…Albumin has been used extensively as a carrier to improve the pharmacokinetic profiles of therapeutic agents or to target a drug to the disease site. 39 the microspheres by the total initial weight of all components in the suspension. Encapsulation (percent) efficiency was calculated by dividing the amount of drug inside the microspheres by the theoretical weight of the drug before microencapsulation.…”

Section: Physicochemical Characterization Of Microspheresmentioning

confidence: 99%

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Enriquez¹,

Rizvi²,

D’Souza³

et al. 2013

IJN

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Enhanced and targeted drug delivery using biodegradable microspheres is emerging as a promising approach for cancer therapy. The main objective of the present research was to formulate, characterize, and evaluate iron oxide (magnetic) containing a bovine serum albumin-based microsphere drug delivery system, capable of efficiently delivering sulforaphane, a histone deacetylase inhibitor, for an extended period of time in vivo. Magnetic microspheres were prepared by spray-drying and characterized for their physicochemical properties and dissolution profile. Further, they were evaluated for therapeutic efficacy in in vitro and in vivo systems. In vitro studies in B16 melanoma cells revealed that there was about 13%-16% more inhibition of cell viability when either 30 µM or 50 µM of sulforaphane was used with iron oxide in the polymeric carrier. Data from in vivo studies in C57BL/6 mice revealed that the magnetic microspheres (localized to the tumor site with the help of a strong magnet) inhibited 18% more tumor growth as compared with sulforaphane in solution. In addition, there was a 40% reduction in histone deacetylation levels in mice treated with iron oxide microspheres containing sulforaphane. Thus, magnetic microspheres are shown to be an effective drug delivery system for anticancer drugs.

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Section: Physicochemical Characterization Of Microspheresmentioning

confidence: 99%

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Enriquez¹,

Rizvi²,

D’Souza³

et al. 2013

IJN

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“…There is a great deal of interest both from a large segment of the pharmaceutical industry and from researchers in the area of biotechnology in the application of albumin as a drug carrier [7]. A remarkable property of albumin is its ability to reversibly bond to a wide variety of molecules [8], which is an interesting characteristic for drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Sitta

Guilherme

Silva

et al. 2014

Colloids and Surfaces B: Biointerfaces

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t Page 4 of 25 A c c e p t e d M a n u s c r i p tsphericity. In such a case, BSA played a role as a surface active agent, replacing PVA. For longer stirring times, BSA was unable to act as an emulsifier.These microparticles showed an uncommon release profile, consisting of a two-step release mechanism, at the pH range studied. Considering that a two-step release mechanism is occurring, the experimental data were adjusted by applying modified power law and Weibull equations in order to describe release mechanism n and release rate constant k, respectively. Each one of the release stages was related to a specific value of n and k. The second stage was driven by a super case II transport mechanism, as a result of diffusion, macromolecular relaxation, and erosion. A third model, described by Hixson-Crowell, confirmed the erosion mechanism.Vit-B 12 diffusion kinetics in aqueous solutions (i.e., without the microparticles) follows a one-step process, being k dependent on the pH, confirming that the two-step release mechanism is a characteristic profile of the developed microparticles. The microparticles released only 2.70% of their initial drug load at pH 2, and 58.53% at pH 10.

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“…45 Of note, already HSA NPs has been used increasingly as delivery system because of their ability to bind to various drug molecules, great stability during storage, no toxicity and antigenicity, and biodegradability. [48][49][50][51] Bunschoten and co-workers also used HSA-based NPs formed non-covalent self assembled complexes with indocyanine green (ICG) dyes toward tumor draining lymph nodes for imaging. 52 Inspired by this strategy, through the synthesis of albumin nanoparticle via novel approaches such as self assembly, it could be possible to control the size of the nanoparticle in a way that can targeted TAAs directly toward the LN and improve the potency of cancer vaccines.…”

Section: Targeted Delivery To Peripheral Dcsmentioning

confidence: 99%

Multifunctional nanoparticles for cancer immunotherapy

Saleh

Shojaosadati

2016

Human Vaccines & Immunotherapeutics

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During the last decades significant progress has been made in the field of cancer immunotherapy. However, cancer vaccines have not been successful in clinical trials due to poor immunogenicity of antigen, limitations of safety associated with traditional systemic delivery as well as the complex regulation of the immune system in tumor microenvironment. In recent years, nanotechnology-based delivery systems have attracted great interest in the field of immunotherapy since they provide new opportunities to fight the cancer. In particular, for delivery of cancer vaccines, multifunctional nanoparticles present many advantages such as targeted delivery to immune cells, co-delivery of therapeutic agents, reduced adverse outcomes, blocked immune checkpoint molecules, and amplify immune activation via the use of stimuli-responsive or immunostimulatory materials. In this review article, we highlight recent progress and future promise of multifunctional nanoparticles that have been applied to enhance the efficiency of cancer vaccines.

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Impact of albumin on drug delivery — New applications on the horizon

Cited by 734 publications

References 120 publications

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Formulation and evaluation of drug-loaded targeted magnetic microspheres for cancer therapy

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Multifunctional nanoparticles for cancer immunotherapy

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