Impact of alcohol consumption on the risk of developing bladder cancer: a systematic review and meta-analysis

Vartolomei, Mihai Dorin; Iwata, Takehiro; Roth, Beat; Kimura, Shoji; Mathiéu, Romain; Ferro, Matteo; Shariat, Shahrokh F.; Seitz, Christian

doi:10.1007/s00345-019-02825-4

Cited by 13 publications

(18 citation statements)

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“…green tea (57) ) and beverages with a potential harmful effect on BC risk (e.g. alcoholic (58) and sweet nonalcoholic beverages (43) ). It, therefore, remains unclear which caused the observed increased BC risk.…”

Section: Discussionmentioning

confidence: 99%

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

Wesselius

Sinhart

et al. 2020

Br J Nutr

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At present, analysis of diet and bladder cancer (BC) is mostly based on the intake of individual foods. The examination of food combinations provides a scope to deal with the complexity and unpredictability of the diet and aims to overcome the limitations of the study of nutrients and foods in isolation. This article aims to demonstrate the usability of supervised data mining methods to extract the food groups related to BC. In order to derive key food groups associated with BC risk, we applied the data mining technique C5.0 with 10-fold cross-validation in the BLadder cancer Epidemiology and Nutritional Determinants study, including data from eighteen case–control and one nested case–cohort study, compromising 8320 BC cases out of 31 551 participants. Dietary data, on the eleven main food groups of the Eurocode 2 Core classification codebook, and relevant non-diet data (i.e. sex, age and smoking status) were available. Primarily, five key food groups were extracted; in order of importance, beverages (non-milk); grains and grain products; vegetables and vegetable products; fats, oils and their products; meats and meat products were associated with BC risk. Since these food groups are corresponded with previously proposed BC-related dietary factors, data mining seems to be a promising technique in the field of nutritional epidemiology and deserves further examination.

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Section: Discussionmentioning

confidence: 99%

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

Wesselius

Sinhart

et al. 2020

Br J Nutr

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“…The Japanese have a higher prevalence of polymorphisms in the aldehyde dehydrogenase 2 (ALDH2) enzyme, which makes them slower at metabolizing acetaldehyde . Previous studies have indeed suggested an elevated cancer risk from alcohol consumption in the urinary tract and prostate in Japan, which has not been found in Western countries . We have hypothesized that there may be an elevated cancer risk at even light to moderate levels of alcohol consumption in Japan due to a higher prevalence of ALDH2 polymorphisms in the Japanese.…”

Section: Introductionmentioning

confidence: 94%

“…9,14 Previous studies have indeed suggested an elevated cancer risk from alcohol consumption in the urinary tract and prostate in Japan, which has not been found in Western countries. 9,10,[15][16][17][18][19] We have hypothesized that there may be an elevated cancer risk at even light to moderate levels of alcohol consumption in Japan due to a higher prevalence of ALDH2 polymorphisms in the Japanese.…”

Section: Introductionmentioning

confidence: 99%

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

Zaitsu

Takeuchi

Kobayashi

et al. 2019

Cancer

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Background Even light to moderate alcohol consumption has been shown to increase cancer incidence. However, this association has not been well characterized in Japan. Methods Based on a nationwide, hospital‐based data set (2005‐2016), a multicenter case‐control study was conducted (63,232 cancer cases and 63,232 controls matched for sex, age, admission date, and admitting hospital). The total amount of lifetime alcohol consumption (drink‐years) was recalled for each patient by multiplication of the daily amount of standardized alcohol use (drinks per day) and the duration of drinking (years). Odds ratios (ORs) were estimated for overall and specific cancer sites via conditional logistic regression with restricted cubic splines, with adjustments made for smoking, occupational class, and comorbidities. Lifetime abstainers served as the reference group. Results Spline curves showed a dose‐response association with overall cancer risk: the minimum risk was at 0 drink‐years, and the OR at 10 drink‐years was 1.05 (95% confidence interval [CI], 1.04‐1.06). In comparison with lifetime abstainers, the OR for >0 to 20 drink‐years was 1.06 (95% CI, 1.01‐1.11). Those who drank 2 drinks or fewer per day had elevated odds for overall cancer risk across all duration‐of‐drinking categories. The same patterns were observed at light to moderate levels of drinking for most gastrointestinal/aerodigestive cancers as well as breast and prostate cancers. Analyses stratified by sex, different drinking/smoking behaviors, and occupational class mostly showed the same patterns for overall cancer incidence associated with light to moderate levels of drinking. Conclusions In Japan, even light to moderate alcohol consumption appears to be associated with elevated cancer risks.

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“…Moreover, cigarette smoking increases the risk of recurrence and progression of non-muscle-invasive bladder cancer (NMIBC) [10]. Alcohol consumption may also increase the risk of UCB, particularly in males [11]. The presence of SNPs in key DNA repair pathways that are involved in the response to DNA damage caused by these environmental carcinogens, including the nucleotide excision repair (NER) and the homologous recombination repair (HRR) pathways, may increase the risk of developing UCB [6,12].…”

Section: Introductionmentioning

confidence: 99%

DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population

et al. 2021

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Single nucleotide polymorphisms (SNPs) in DNA repair genes may predispose to urothelial carcinoma of the bladder (UCB). This study focused on three specific SNPs in a population with high exposure to environmental carcinogens including tobacco and alcohol. A case-control study design was used to assess for presence of XPC PAT +/−, XRCC3 Thr241Met, and ERCC2 Lys751Gln DNA repair gene SNPs in peripheral blood from patients with UCB and healthy individuals. One hundred patients and equal number of healthy subjects were enrolled. The XPC PAT +/+ genotype was associated with a 2-fold increased risk of UCB (OR = 2.16; 95%CI: 1.14–4; p = 0.01). The −/+ and +/+ XPC PAT genotypes were more frequently present in patients with multiple versus single tumors (p = 0.01). No association was detected between ERCC2 Lys751Gln genotypes/alleles, and risk for developing UCB. Presence of the XRCC3 TT genotype (OR = 0.14; 95%CI:0.07–0.25; p < 0.01) and of the T allele overall (OR = 0.26; 95%CI:0.16–0.41; p < 0.01) conferred a protective effect against developing UCB. The XPC PAT −/+ and XRCC3 Thr241Met SNPs are associated with predisposition to UCB. The XPC PAT −/+ SNP is also an indicator of bladder tumor multiplicity, which might require a more individualized surveillance and treatment.

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Impact of alcohol consumption on the risk of developing bladder cancer: a systematic review and meta-analysis

Cited by 13 publications

References 50 publications

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

A data mining approach to investigate food groups related to incidence of bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants International Study

Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan

DNA Repair Gene Polymorphisms and Susceptibility to Urothelial Carcinoma in a Southeastern European Population

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