Impact of Alcohol Intake on Measures of Lipid Metabolism Depends on Context Defined by Gender, Body Mass Index, Cigarette Smoking, and<i>Apolipoprotein E</i>Genotype

Lussier‐Cacan, Suzanne; Bolduc, Aline; Xhignesse, Marianne; Niyonsenga, Théophile; Sing, Charles F.

doi:10.1161/01.atv.0000014589.22121.6c

Cited by 54 publications

(36 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies other than ours have also failed to find any effect of these factors on blood EPA and DHA levels (Ma et al, 1995). However, the decision was made to include BMI and smoking because of a potential effect of fat reservoirs and smoking on blood lipid levels (Wood et al, 1987;Bonaa et al, 1992;Lussier-Cacan et al, 2002), and sex because this factor, in combination with age, accounts for most of the inter-person variation in energy and nutrient intakes (Willett, 1990).…”

Section: Discussionmentioning

confidence: 89%

A valid semiquantitative food frequency questionnaire to measure fish consumption

2007

View full text Add to dashboard Cite

Objective: To validate a detailed semiquantitative food frequency questionnaire designed to measure habitual fish and seafood consumption. Design: Cross-sectional validation study using an independent biomarker of fish consumption. Setting: Perth metropolitan area, Western Australia. Subjects: Ninety-one healthy volunteers of both sexes aged 21-75 years. Methods: Participants completed the questionnaire and provided a fasting blood sample for erythrocyte membrane omega-3 fatty acid (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) analysis. The questionnaire was then validated by linear regression analysis of EPA and DHA levels on categories of fish and seafood and overall consumption, adjusted for age, sex, smoking status, body mass index (BMI) and alcohol intake. Results: Regression coefficients were statistically significant for most fish and seafood items with both EPA and DHA. The strongest association was observed between oily fish and EPA, whereas no significant association was observed between lean fish and omega-3 fatty acids. Variation in omega-3 fatty acids was best accounted for by a model containing variables representing different categories of fish and seafood consumption (R 2 0.484), rather than a single variable representing overall fish and seafood consumption (R 2 0.313).Conclusions: This study confirms that the varying content of omega-3 fatty acids in foods are reflected in omega-3 biomarkers, and that the questionnaire is a valid measure of fish consumption that enables differentiation between cooking and processing methods and oily versus lean fish intake.

show abstract

Section: Discussionmentioning

confidence: 89%

A valid semiquantitative food frequency questionnaire to measure fish consumption

2007

View full text Add to dashboard Cite

show abstract

“…The reasons for the sex difference in the association between alcohol intake and serum triglycerides are unclear and may simply be caused by confounding. However, differences in frequency of alcohol intake, 31 levels of sex hormone-binding globulin, 32 and genetic polymorphism in the apolipoprotein CIII, 33 apolipoprotein E, 34 and other factors controlling lipid metabolism may be involved.…”

Section: Discussionmentioning

confidence: 99%

Coronary Atherosclerosis and Alcohol Consumption

Femia

Natali

LʼAbbate

et al. 2006

ATVB

View full text Add to dashboard Cite

Objective-Moderate alcohol consumption is associated with reduced cardiovascular disease (CVD) risk. Whether this protection is based on a lesser degree of coronary atherosclerosis has not been established. Methods and Results-We studied 1676 men and 465 women consecutively undergoing coronary angiography. A score (ATS) was calculated by summing the percent lumen narrowing of all main vessels; alcohol consumption was quantitated by questionnaire. In univariate analysis, ATS was significantly (PՅ0.001) associated with male sex, age, familial CVD, smoking, diabetes, hypertension, and serum cholesterol levels; alcohol consumption was associated with less frequent diabetes (PϽ0.001) and lower ATS (Pϭ0.02 1 In a recent analysis of the modifiable risk factors for acute myocardial infarction in 52 countries, 2 regular alcohol consumption was independently associated with reduced incident myocardial infarction in both sexes, at all ages and in all regions. A number of mechanisms have been postulated to explain this association, including an increase in serum high-density lipoprotein (HDL) and apolipoprotein-A 1 levels, 3 anticoagulant effects-by either direct platelet inhibition or inhibition of the fibrinolytic system 4 -6 -a reduction in inflammation, 7 and an enhancement of insulin sensitivity. 8 The physiological basis for the protective effect of alcohol is, however, less certain. The 6 angiographic studies in the English literature 9 -14 (Table I, please see http://atvb. ahajournals.org) have included only men (nϭ4) or only women (nϭ1), are of limited size, have used variable adjustment for relevant CVD risk factors, and mostly (5 of 6) lack follow-up data. This prompted the present study, in which the association of alcohol consumption with angiographically quantified coronary atherosclerosis was analyzed in a large cohort of men and women, in whom information on classical CVD risk factors and clinical outcome was available. Materials and Methods PatientsFrom 1983 to 1992, 2141 of the 4754 patients admitted to our coronary division underwent coronary angiography as part of the clinical work-up of symptoms or signs of heart disease. The indications for angiography were: acute myocardial infarction (nϭ43), previous myocardial infarction (nϭ213), cardiomyopathy (nϭ118), valvular disease (nϭ105), arrhythmias (nϭ30), unstable angina (nϭ34), acute pulmonary edema (nϭ6); the remainder of the patients had signs or symptoms of myocardial ischemia. Clinically, 52% of men and 56% of women presented with angina on effort, whereas 75% of men and 26% of women presented with resting angina; 56% of the cases presented with both. Since 1983, the relevant clinical data of each patient have been transferred immediately after discharge to a database created for this purpose. Each patient record consisted of the following blocks of information: (1) demographic data (sex, age, height, weight, years of school education); (2) clinical data (history of resting or effort angina, myocardial infarction, acute cerebrovascular events, coro...

show abstract

“…Some population-based studies have also reported that e4 carriers are at increased risk for CVD (48). In contrast, only a few studies have reported pleiotropic effects of the six genotypes determined by the cSNPs at positions 3937 and 4075 on HDL-C and TG (13,32,37,49). The percentage of interindividual variation in HDL-C explained by these genotypes in a sample of Danish females is relatively small and depends on age (32).…”

Section: Lipid Phenotype-apoe Genotype Statistical Modelsmentioning

confidence: 99%

“…Studies of the influence of the variation in the gene coding for apolipoprotein E (APOE) on quantitative blood measures of lipid metabolism have demonstrated both context-dependent genotype effects (12)(13)(14) and phenotype-APOE genotype relationships that are less sensitive to contexts indexed by time and space (12,14,15). In the study reported here, we use data collected from three populations that are ethnically and geographically distinct to identify phenotype-APOE genotype relationships that are less sensitive to the influence of genetic and environmental contexts indexed by gender, ethnicity, and geographic location.…”

mentioning

confidence: 99%

Contribution of regulatory and structural variations in APOE to predicting dyslipidemia

Stengård

Kardia

Hamon

et al. 2006

Journal of Lipid Research

Self Cite

View full text Add to dashboard Cite

The objective of this study was to evaluate 1) whether non single nucleotide polymorphisms-coding (noncSNP) in the apolipoprotein E gene (APOE ) identified by resequencing studies contribute to statistically explaining dyslipidemia if variations in the two cSNPs in exon 4 that define the «2, «3, and «4 alleles are ignored, and 2) whether the contribution of these additional SNPs persists when variations in the cSNPs are considered. We used an ecological, multiple-population, data-mining strategy to identify single-SNP and two-SNP genotypes that distinguish between high and low levels of plasma lipids in three training samples, European-Americans from Rochester, MN, AfricanAmericans from Jackson, MS, and Europeans from North Karelia, Finland. We found that a pair of SNPs located in the 59 region define genotypes A 560 T 832 /A 560 T 832 , A 560 T 832 / A 560 G 832 , and A 560 T 832 /T 560 T 832 , which distinguish between high and low levels of HDL-cholesterol (HDL-C), triglycerides (TG),and/ortotalcholesterol(T-C).The A 560 T 832 /-genotypes predicted high TG and high T-C in both genders in a large independent test sample from Copenhagen, Denmark. Prediction of high T-C in the Danish females was dependent on genotypes defined by the cSNPs. Our study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE for predicting dyslipidemia in the population at large.-Stengård, J. H., S. L. R. Kardia, S. C. Hamon, R. Frikke-Schmidt, A. TybjaergHansen, V. Salomaa, E. Boerwinkle, and C. F. Sing. Contribution of regulatory and structural variations in APOE to predicting dyslipidemia. Cholesterol accumulation in arterial walls is an important contributing factor in the development of atherosclerotic cardiovascular disease (CVD) (1). Information about the genetic basis of interindividual differences in lipid metabolism is thus expected to be useful in risk assessment, providing clues for the development of nonpharmacological and pharmacological interventions and suggesting population-based disease prevention strategies for CVD (2-5). A plethora of variations in genes involved in lipid metabolism have been characterized (6-10). The statistical evaluation of the contributions of these genomic variations to variation in measures of lipid metabolism and risk of CVD presents one of the most difficult challenges facing CVD research. The biological realities that interactions between gene variations and environmental variations are the primary causes of interindividual differences in lipid metabolism and risk of CVD, and that these interactions are dynamic over the lifetime of the individual, serve as major obstacles for the study of phenotype-genotype relationships (11).Studies of the influence of the variation in the gene coding for apolipoprotein E (APOE) on quantitative blood measures of lipid metabolism have demonstrated both context-dependent genotype effects (12-14) and phenotype-APOE genotype relationships that are less sensitive to contexts indexed by time an...

show abstract

Impact of Alcohol Intake on Measures of Lipid Metabolism Depends on Context Defined by Gender, Body Mass Index, Cigarette Smoking, andApolipoprotein EGenotype

Cited by 54 publications

References 35 publications

A valid semiquantitative food frequency questionnaire to measure fish consumption

A valid semiquantitative food frequency questionnaire to measure fish consumption

Coronary Atherosclerosis and Alcohol Consumption

Contribution of regulatory and structural variations in APOE to predicting dyslipidemia

Contact Info

Product

Resources

About