2016
DOI: 10.1111/adb.12481
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Impact of alcohol use on EEG dynamics of response inhibition: a cotwin control analysis

Abstract: Research indicates that alcohol misuse is associated with behavioral disinhibition, but the neurophysiological mechanisms governing this relationship remain largely unknown. Recent work suggests that successful inhibition and cognitive control involve electrophysiological theta-band dynamics, including medial frontal cortex (MFC) power enhancement and functional connectivity between the MFC and dorsal prefrontal cortex (dPFC) regions, which may be disrupted by alcohol misuse. In addition, research suggests tha… Show more

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Cited by 23 publications
(25 citation statements)
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“…Prior research offers strong support for the construct and psychometric validity of this composite index, including high internal consistency and expected parent-offspring correlations when assessed throughout adolescence (McGue et al, 2014). In addition, higher index scores have been associated with reduced prefrontal grey matter volume and neurocognitive performance in adolescents (Malone et al, 2014; Wilson et al, 2015), and diminished response inhibition-related theta-band MFC power and MFC-dPFC connectivity in young adults (Harper et al, 2016). …”
Section: Methodsmentioning
confidence: 99%
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“…Prior research offers strong support for the construct and psychometric validity of this composite index, including high internal consistency and expected parent-offspring correlations when assessed throughout adolescence (McGue et al, 2014). In addition, higher index scores have been associated with reduced prefrontal grey matter volume and neurocognitive performance in adolescents (Malone et al, 2014; Wilson et al, 2015), and diminished response inhibition-related theta-band MFC power and MFC-dPFC connectivity in young adults (Harper et al, 2016). …”
Section: Methodsmentioning
confidence: 99%
“…Guided by prior work (Cohen and Cavanagh, 2011; Harper et al, 2016; Nigbur et al, 2012) and a priori hypotheses regarding theta-band functional connectivity between MFC and dorsal prefrontal cortex (dPFC) electrodes during response conflict/cognitive control (Clayton et al, 2015), pairwise wPLI values were calculated between MFC seed electrode FCz and all other channels. As seen in Figure 1B, the grand averaged plots of connectivity between FCz and a cluster of dPFC electrodes (Fz/F1-4/AFz/AF3-4) revealed a focal connectivity enhancement across a 3–8 Hz and 344–594 ms post-stimulus window.…”
Section: Methodsmentioning
confidence: 99%
“…Signals were processed using MATLAB (version 7.1, Mathworks, Inc.) and EEGLAB software (Delorme & Makeig, 2004) as described in (Harper et al, 2017a; Harper, Malone, & Iacono, 2017b; Harper et al, 2018). Continuous signals were resampled at 256-Hz, highpass filtered ( firfilt plugin; 0.1 Hz cutoff), and re-referenced to mean earlobe signals.…”
Section: Methodsmentioning
confidence: 99%
“…Converging evidence suggests the presence of AUD-related anomalies across multiple measures of the prefrontal cortex. These include reduced grey and white matter volume (Welch, Carson, & Lawrie, 2013), suboptimal neurocognitive performance (Lopez-Caneda, Holguin, Cadaveira, Corral, & Doallo, 2014; Smith, Mattick, Jamadar, & Iredale, 2014; VerdejoGarcia, Lawrence, & Clark, 2008), and functional abnormalities during executive functioning tasks (Burwell, Malone, Bernat, & Iacono, 2014; Feil et al, 2010; Goldstein & Volkow, 2011; Harper, Malone, & Iacono, 2018; Kamarajan et al., 2004; Pandey et al, 2012). Strong empirical evidence suggests that cognitive control is potentially biophysically realized (in part) through rhythmic electroencephalographic (EEG) signals, such as medial frontal (MF) cortex theta-band (3–8 Hz) activity (Cavanagh & Frank, 2014; Cohen, 2014a).…”
Section: Introductionmentioning
confidence: 99%
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