2021
DOI: 10.3390/cells10061552
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Impact of Aldosterone on the Failing Myocardium: Insights from Mitochondria and Adrenergic Receptors Signaling and Function

Abstract: The mineralocorticoid aldosterone regulates electrolyte and blood volume homeostasis, but it also adversely modulates the structure and function of the chronically failing heart, through its elevated production in chronic human post-myocardial infarction (MI) heart failure (HF). By activating the mineralocorticoid receptor (MR), a ligand-regulated transcription factor, aldosterone promotes inflammation and fibrosis of the heart, while increasing oxidative stress, ultimately induding mitochondrial dysfunction i… Show more

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Cited by 13 publications
(11 citation statements)
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“…The mechanisms underlying mitomiRs biogenesis and action sites are still poorly understood, however they are a fascinating class of miRNAs which could allow to track the mitochondrial status and health in pathological conditions (Latronico and Condorelli, 2012). Indeed, differentially expressed mitomiRs have been observed in heart failure (Pinti et al, 2017;Wang et al, 2017), where mitochondrial dysfunction is evident (Santulli et al, 2015;Sties et al, 2018;Del Campo et al, 2021;Guitart-Mampel et al, 2021;Morciano et al, 2021;Yang et al, 2021;Schwemmlein et al, 2022). Despite their potential power in mirroring systemic mitochondrial homeostasis, the assessment of mitomiRs in FD has never been contemplated.…”
Section: Introductionmentioning
confidence: 99%
“…The mechanisms underlying mitomiRs biogenesis and action sites are still poorly understood, however they are a fascinating class of miRNAs which could allow to track the mitochondrial status and health in pathological conditions (Latronico and Condorelli, 2012). Indeed, differentially expressed mitomiRs have been observed in heart failure (Pinti et al, 2017;Wang et al, 2017), where mitochondrial dysfunction is evident (Santulli et al, 2015;Sties et al, 2018;Del Campo et al, 2021;Guitart-Mampel et al, 2021;Morciano et al, 2021;Yang et al, 2021;Schwemmlein et al, 2022). Despite their potential power in mirroring systemic mitochondrial homeostasis, the assessment of mitomiRs in FD has never been contemplated.…”
Section: Introductionmentioning
confidence: 99%
“…Spironolactone is known to reduce morbidity and mortality in patients with severe HFrEF [28]. It exerts its beneficial effects through mineralocorticoid receptor (MR) blockade and may thereby attenuate maladaptive downstream effects through aldosterone-mediated MR activation, e.g., increases in reactive oxygen species, inflammation, fibrosis, mito-chondrial dysfunction and adrenergic receptor modulation [29,30]. In the Aldo-DHF trial, distinct beneficial effects through spironolactone treatment in HFpEF patients were demonstrated including an improvement of diastolic function and neuroendocrine activation, as well as a reduction of adverse cardiac remodelling [5].…”
Section: Discussionmentioning
confidence: 99%
“…Excessive activation of RAAS causes abnormal production of Ang II and aldosterone in the blood circulation, which can activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in the heart, promoting ROS generation and leading to oxidative stress [ 11 , 24 , 33 ]. Oxidative stress promotes the development of arteriosclerosis and cardiac fibrosis, accelerating the occurrence and development of CRS [ 34 , 35 ].…”
Section: The Role Of Raas-mediated Oxidative Stress In Crsmentioning
confidence: 99%
“…These effects can lead to mitochondrial and adrenergic receptor dysfunction and coronary vasoconstriction which can lead to HF. Moreover, aldosterone stimulates epidermal growth factor receptor activation through activating MR, which regulates the RAAS and ultimately modulates cardiac physiology [ 24 ].…”
Section: Brief Introduction Of the Raasmentioning
confidence: 99%