Impact of Alteplase on Mortality in Critically Ill Patients with COVID-19 and Pulmonary Embolism

Oliynyk, Oleksandr Valentynovych; Rorat, Marta; Solyarik, Serhij Oleksandrovych; Lukianchuk, Vitaliy Andrijovych; Dubrov, Serhij Oleksandrovych; Guryanov, Vitaliy Hrygorovych; Oliynyk, Yanina Volodymyrivna; Yaroslavskaya, Svitlana Mykolaivna; Szalast, Roman; Barg, Wojciech

doi:10.3390/v15071513

Cited by 6 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This suggests a chronic inflammatory response, a trend observed in patients experiencing more severe COVID-19 progression. 18 , 20 Variations in the CD4/CD8 ratio between the two groups have been a topic of continued research, with prior findings highlighting similar tendencies towards either hyperimmune reactions or immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

Immune response variation in mild and severe COVID-19 patients

Stroz,

Kosiorek,

Zbroch

et al. 2024

Qatar Medical Journal

View full text Add to dashboard Cite

Sixty patients with COVID-19 infection were categorized into mild and severe groups, and their immune response was analyzed using flow cytometry and complete blood count. An observed increase in immune activation parameters, notably a higher percentage of CD4 lymphocytes co-expressing CD69 and CD25 molecules, and enhanced activity of the macrophage-monocyte cell line was noted in the mild group. Although Group 2 (severe COVID) had fewer CD4 cells, significant migration and proliferation were evident, with increased CD4CD69, CD8 HLA-DR+, and CD8CD69 lymphocytes. The CD4 to CD8 ratio in Group 1 suggested potential autoimmune reactions, while Group 2 indicated potential immunosuppression from severe infection and employing immunosuppressive drugs. Additionally, Group 2 exhibited an increased neutrophil count, hinting at possible bacterial co-infection. Group 1 showed differences in CD4RO and CD8RA lymphocyte populations, implying that cellular immunity plays a role in developing efficient postinfectious immunity. This intimation suggests that vaccination might mitigate the severity of the coronavirus infection and prevent complications, including long-term COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%

Immune response variation in mild and severe COVID-19 patients

Stroz,

Kosiorek,

Zbroch

et al. 2024

Qatar Medical Journal

View full text Add to dashboard Cite

show abstract

“…11,12 In severe cases of COVID-19 infections, especially with right heart thrombus and pulmonary embolism, thrombolysis should be done as soon as possible. 13 Additional research is warranted to explore the screening and thrombolysis approaches, particularly in cases of severe COVID-19 infection accompanied by RVT.…”

Section: Casementioning

confidence: 99%

Right Ventricle Thrombus and COVID-19 Infection: An Uncommon Report of Three Cases

Mittal,

Patel,

Patel

et al. 2023

Indian Journal of Critical Care Case Report

View full text Add to dashboard Cite

Case seriesthrombolyzed with 100 mg injection actilyse [recombinant tissue plasminogen activator (rt-PA)] over 2 hours. 2D-echo was repeated again (Video 2) and showed reduction in the size of thrombus. After 10 days, oxygen requirement was reduced to 5-6 L/minute, and in another 10-11 days, patient was shifted out of ICU and was finally discharged after 24 days of admission. Following discharge, patient was advised to take dabigatran 150 mg 12 hourly.

show abstract

Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Stróż,

Kosiorek,

Zbroch

et al. 2024

Pol. Ann. Med.

View full text Add to dashboard Cite

IntroductionCOVID-19 can have long-lasting effects, but the effects on blood parameters and inflammation are poorly understood. The aim of this study was to evaluate morphological and inflammatory markers in long-term COVID-19 patients.AimTo evaluate complete blood count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and morphology in mild versus severe long COVID-19.Material and methodsIn total, 39 long COVID-19 patients were stratified into mild (<i>n</i> = 25) and severe (<i>n</i> = 14) groups. Blood counts, NLR, PLR were measured. Cell morphology was analysed. ROC curves were used to determine biomarker thresholds. Survival was assessed using Kaplan–Meier curves.Results and discussionSevere patients had lower leukocytes but higher neutrophils, indicating greater inflammation. NLR and PLR were significantly increased in severe patients compared to mild patients (NLR 12 vs 8; PLR 140 vs 100). NLR and PLR were higher than in controls, confirming their utility as inflammatory markers. NLR and PLR effectively discriminated between mild and severe disease. High NLR and PLR predicted poorer prognosis. Altered leukocyte morphology such as cytoplasmic vacuolization correlated with severity.ConclusionsNLR and PLR are promising biomarkers for assessing severity of long COVID-19, while morphological changes in blood cells provide additional evidence of inflammation. Further studies in larger populations are warranted.

show abstract

Impact of Alteplase on Mortality in Critically Ill Patients with COVID-19 and Pulmonary Embolism

Cited by 6 publications

References 54 publications

Immune response variation in mild and severe COVID-19 patients

Immune response variation in mild and severe COVID-19 patients

Right Ventricle Thrombus and COVID-19 Infection: An Uncommon Report of Three Cases

Evaluation of morphological parameters, PLR and NLR inflammation indicators in patients with long-term COVID-19 of mild and severe complexity

Contact Info

Product

Resources

About