Impact of ambient PM2.5 on adverse birth outcome and potential molecular mechanism

Zhou, Li; Tang, Yongming; Song, Xin; Lazar, Lissy; Zhen, Li; Zhao, Jinshun

doi:10.1016/j.ecoenv.2018.10.109

Cited by 144 publications

(59 citation statements)

References 88 publications

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“…While it is well accepted that high ambient PM levels correlate with the mortality rate, it is increasingly recognised that long-term exposure to even low level of PM (quite often considered as “safe level”) increases the risk of disorders in vital organ systems, including the heart, the lung and the brain [ 48 , 49 ]. Although not widely studied, PMs are now considered an in utero environmental toxin [ 9 , 50 ] and therefore of interest to this perspective paper. Here, we summarised the currently available evidence from a limited number of publications to raise the awareness of the needs for more comprehensive research into this currently understudied yet important health topic.…”

Section: Particulate Matter (Pm)—an Intrauterine Toxinmentioning

confidence: 99%

Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

et al. 2021

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Air pollution is the 9th cause of the overall disease burden globally. The solid component in the polluted air, particulate matters (PMs) with a diameter of 2.5 μm or smaller (PM2.5) possess a significant health risk to several organ systems. PM2.5 has also been shown to cross the blood–placental barrier and circulate in foetal blood. Therefore, it is considered an intrauterine environmental toxin. Exposure to PM2.5 during the perinatal period, when the foetus is particularly susceptible to developmental defects, has been shown to reduce birth weight and cause preterm birth, with an increase in adult disease susceptibility in the offspring. However, few studies have thoroughly studied the health outcome of foetuses due to intrauterine exposure and the underlying mechanisms. This perspective summarises currently available evidence, which suggests that intrauterine exposure to PM2.5 promotes oxidative stress and inflammation in a similar manner as occurs in response to direct PM exposure. Oxidative stress and inflammation are likely to be the common mechanisms underlying the dysfunction of multiple systems, offering potential targets for preventative strategies in pregnant mothers for an optimal foetal outcome.

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Section: Particulate Matter (Pm)—an Intrauterine Toxinmentioning

confidence: 99%

Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

et al. 2021

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“…Some studies have reported that atmospheric PM2.5 can enter the blood circulation and reach the maternal placenta causing or aggravating oxidative stress and inflammation, resulting in placental dysfunction and even preeclampsia (Brunst et al 2018 ; Dadvand et al 2013 ; Li et al 2019 ; Slama et al 2008 ). There is increasing evidence that PM2.5 exposure during pregnancy is positively associated with the risk of preeclampsia (Assibey-Mensah et al 2020 ; Dadvand et al 2013 , 2014 ; Lee et al 2013 ; Mandakh et al 2020 ; Rudra et al 2011 ; Wu et al 2009 ); some studies have even suggested that PM2.5 exposure during a particular gestational period can increase the risk of preeclampsia (Lee et al 2013 ; Mandakh et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis

Yin

Zhang

et al. 2020

Environ Sci Pollut Res

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There is increasing and inconsistent evidence of a linkage between maternal exposure to particulate matter 2.5 (PM2.5) and preeclampsia. Therefore, this study was conducted to investigate this relationship. Electronic databases including PubMed, Embase, Web of Science, and Cochrane Library were searched to identify articles published from inception to March 23, 2020, which showed a correlation between PM2.5 and preeclampsia. Finally, 9 of 523 initial studies were deemed eligible for inclusion. A random effect model was adopted to calculate the standardized odds ratio (OR) and 95% confidence interval (CI). Based on potential effect modification, subgroup analyses were further performed. Meta-analysis showed that maternal exposure to PM2.5 (per 10 μg/m3 increment) elevated the risk of preeclampsia (OR = 1.32, 95% CI 1.10 to 1.58%). Compared with other pregnancy trimesters, the third trimester of pregnancy seems to be the period in which women are more susceptible to PM2.5. Significant effect modification of the correlation between PM2.5 exposure and preeclampsia according to multiple pregnancies, pregnancy stage, maternal-related disease history, and sample size was not observed. The results demonstrated that maternal exposure to PM2.5 may predispose pregnant women to develop preeclampsia, especially in the third trimester of pregnancy. Therefore, more efforts should be made to improve air quality to maintain the health of pregnant women.

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“…Various indoor and outdoor air pollutants are linked in epidemiology studies to the symptoms, hospital admissions and development of numerous health outcomes such as asthma (Fan et al 2016 ), cardiovascular disease (Cesaroni et al 2014 ; Wang et al 2015 ; Münzel et al 2018 ), skin diseases (Balmes 2019 ), birth outcomes (Li et al 2019 ), sperm quality (Lafuente et al 2016 ), type 1 and 2 diabetes (Ritz et al 2019 ; Howard 2019 ), lung cancer (Lipfert and Wyzga 2019 , Hamra et al 2014 )—even with the spread and increase of Covid-19’s morbidity and mortality (Bilal et al 2020 ; Comunian et al 2020 ; Rodríguez-Urrego and Rodríguez-Urrego 2020 ) and other disease mortality (Fajersztajn et al 2017 ; Liu et al 2019 ; Orellano et al 2020 ). Most of these epidemiology studies were conducted in the developed world and very few in Africa (Ostro et al 2018 ; Rodríguez-Urrego and Rodríguez-Urrego 2020 , Orellano et al 2020 ; Liu et al 2019 ; Ofori et al 2020 , Katoto et al 2019 ; Wichmann and Voyi 2012 ; Coker and Kizito 2018 ; Lokotola et al 2020 ).…”

Section: Introductionmentioning

confidence: 99%

PM2.5 chemical composition and geographical origin of air masses in Cape Town, South Africa

Williams

Petrik

Wichmann

2020

Air Qual Atmos Health

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PM 2.5 in the indoor and outdoor environment has been linked in epidemiology studies to the symptoms, hospital admissions and development of numerous health outcomes including death. The study was conducted during April 2017 and April 2018. PM 2.5 samples were collected over 24 h and every third day. The mean PM 2.5 level was 13.4 μg m −3 (range: 1.17-39.1 μg m −3). PM 2.5 levels exceeded the daily World Health Organization air quality guideline (25 μg m −3) on 14 occasions. The mean soot level was 1.38 m −1 × 10 −5 (range: 0 to 5.38 m −1 × 10 −5). Cl − , NO 3 − , SO 4 2− , Al, Ca, Fe, Mg, Na and Zn were detected in the PM 2.5 samples. The geographical origin of air masses that passed Cape Town was estimated using the Hybrid Single Particle Lagrangian Integrated Trajectory software. Four air masses were identified in the cluster analysis: Atlantic-Ocean-WSW, Atlantic-Ocean-SW, Atlantic-Ocean-SSW and Indian-Ocean. The population of Cape Town may experience various health outcomes from the outdoor exposure to PM 2.5 and the chemical composition of PM 2.5 .

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Impact of ambient PM2.5 on adverse birth outcome and potential molecular mechanism

Cited by 144 publications

References 88 publications

Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

Particulate Matter, an Intrauterine Toxin Affecting Foetal Development and Beyond

The impact of particulate matter 2.5 on the risk of preeclampsia: an updated systematic review and meta-analysis

PM2.5 chemical composition and geographical origin of air masses in Cape Town, South Africa

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