Impact of Amino Acids Nutrition Following Gastrectomy in Gastric Cancer Patients

Kikuchi, Shinichi; Takata, Nobuo; Kuroda, Shinji; Umeda, Hibiki; Tanabe, Shunsuke; Maeda, Naoaki; Takagi, Kosei; Noma, Kazuhiro; Hasegawa, Yūko; Nawachi, Kumiko; Kagawa, Shunsuke; Umeda, Yuzo; Shikata, Kenichi; Fujiwara, Toshiyoshi

doi:10.21873/anticanres.15852

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Particularly in cases with a short postoperative period, a peripheral parenteral nutrition (PPN) solution, which is generally designed to have lower energy and sufficient amino acid content, is usually used via the peripheral route [ 23 , 24 ]. The postoperative administration of PPN with an oral nutritional supplement (ONS) prevented body weight loss and skeletal muscle loss compared with 4.3% glucose fluid in patients with gastrectomy [ 25 ]. However, to the best of our knowledge, the influence of PPN, especially AA infusion, has not been explored.…”

Section: Introductionmentioning

confidence: 99%

Combination of Parenteral Amino Acid Infusion and Intermittent Loading Exercise Ameliorates Progression of Postoperative Sarcopenia in Rat Model

Wada,

Yamashita,

Togashi

et al. 2024

Nutrients

View full text Add to dashboard Cite

Postoperative sarcopenia is associated with poor outcomes in hospitalized patients. However, few studies have focused on short-term postoperative sarcopenia. Furthermore, the influence of nutritional management using amino acids (AAs) comprising a peripheral parenteral nutrition (PPN) solution and its combination with exercise (Exc) is unclear. Hence, we established a postoperative sarcopenic rat model to evaluate the effects of parenteral AA infusion combined with Exc on skeletal muscles and investigate the underlying mechanisms involved in the amelioration of muscle atrophy. Male F344 rats underwent surgery followed by hindlimb suspension (HS) for 5 days. The rats were divided into AA (−), AA (+), AA (−)-Exc, and AA (+)-Exc groups. They were continuously administered a PPN solution with or without AA at 98 kcal/kg/day. The Exc groups were subjected to intermittent loading for 1 h per day. Postoperative sarcopenic rats exhibited decreased muscle strength and mass and an upregulated ubiquitin–proteasome system, autophagy–lysosome system, and fast-twitch fiber-related genes, especially in the AA (−) group. The AA (+)-Exc group exhibited attenuated decreased muscle strength, increased gastrocnemius mass, and a suppressed upregulation of muscle atrophy- and fast-twitch fiber-related genes. Therefore, parenteral AA infusion combined with Exc may be effective in preventing postoperative sarcopenia in hospitalized patients.

show abstract

Section: Introductionmentioning

confidence: 99%